Communication: Comparison of Respiratory Specimens for the Detection of SARS-CoV-2

Jee Soo Lee; Myoung Seock Seo; Tae Rin Gwon; Sung Im Cho; Young Gon Kim; Man Jin Kim; Jae Hyeon Park; Chang Kyung Kang; Pyoeng Gyun Choe; Wan BeomPark; Nam Joong Kim; Myoung Don Oh; Taek Soo Kim; Sung Sup Park; Moon Woo Seong

Communication: Comparison of Respiratory Specimens for the Detection of SARS-CoV-2

Jee Soo Lee, Myoung Seock Seo, Tae Rin Gwon, Sung Im Cho, Young Gon Kim, Man Jin Kim, Jae Hyeon Park, Chang Kyung Kang, Pyoeng Gyun Choe, Wan BeomPark, Nam Joong Kim, Myoung Don Oh, Taek Soo Kim, Sung Sup Park, Moon Woo Seong

Research output: Contribution to journal › Article › peer-review

Abstract

We compared SARS-CoV-2 detection rate of different respiratory specimens (nasopharyngeal swab [NPS], n=92; oropharyngeal swab [OPS], n=18; sputum, n=11). We also compared cycle threshold (Ct) values of paired specimen types obtained from the same patient on the same day.Then we characterized viral load kinetics of NPS (n=142), OPS (n=126), and sputum (n=75), during disease course. Sputum samples showed higher detection rate than NPS, and OPS exhibited the lowest detection rate.The median Ct values in NPS were significantly lower than in paired OPS, and higher than in paired sputum, respectively (P<0.05). During the disease course, viral load was the lowest in OPS and the highest in sputum samples.

Original language	English
Pages (from-to)	140-144
Number of pages	5
Journal	Annals of clinical and laboratory science
Volume	51
Issue number	1
State	Published - Jan 2021

Bibliographical note

Publisher Copyright:
© 2021 by the Association of Clinical Scientists, Inc.

Keywords

COVID-19
Real-Time Polymerase Chain Reaction
Severe Acute Respiratory Syndrome Coronavirus 2
Viral Load

Cite this

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title = "Communication: Comparison of Respiratory Specimens for the Detection of SARS-CoV-2",

abstract = "We compared SARS-CoV-2 detection rate of different respiratory specimens (nasopharyngeal swab [NPS], n=92; oropharyngeal swab [OPS], n=18; sputum, n=11). We also compared cycle threshold (Ct) values of paired specimen types obtained from the same patient on the same day.Then we characterized viral load kinetics of NPS (n=142), OPS (n=126), and sputum (n=75), during disease course. Sputum samples showed higher detection rate than NPS, and OPS exhibited the lowest detection rate.The median Ct values in NPS were significantly lower than in paired OPS, and higher than in paired sputum, respectively (P<0.05). During the disease course, viral load was the lowest in OPS and the highest in sputum samples.",

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author = "Lee, {Jee Soo} and Seo, {Myoung Seock} and Gwon, {Tae Rin} and Cho, {Sung Im} and Kim, {Young Gon} and Kim, {Man Jin} and Park, {Jae Hyeon} and Kang, {Chang Kyung} and Choe, {Pyoeng Gyun} and Wan BeomPark and Kim, {Nam Joong} and Oh, {Myoung Don} and Kim, {Taek Soo} and Park, {Sung Sup} and Seong, {Moon Woo}",

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year = "2021",

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language = "English",

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AU - Seo, Myoung Seock

AU - Gwon, Tae Rin

AU - Cho, Sung Im

AU - Kim, Young Gon

AU - Kim, Man Jin

AU - Park, Jae Hyeon

AU - Kang, Chang Kyung

AU - Choe, Pyoeng Gyun

AU - BeomPark, Wan

AU - Kim, Nam Joong

AU - Oh, Myoung Don

AU - Kim, Taek Soo

AU - Park, Sung Sup

AU - Seong, Moon Woo

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AB - We compared SARS-CoV-2 detection rate of different respiratory specimens (nasopharyngeal swab [NPS], n=92; oropharyngeal swab [OPS], n=18; sputum, n=11). We also compared cycle threshold (Ct) values of paired specimen types obtained from the same patient on the same day.Then we characterized viral load kinetics of NPS (n=142), OPS (n=126), and sputum (n=75), during disease course. Sputum samples showed higher detection rate than NPS, and OPS exhibited the lowest detection rate.The median Ct values in NPS were significantly lower than in paired OPS, and higher than in paired sputum, respectively (P<0.05). During the disease course, viral load was the lowest in OPS and the highest in sputum samples.

KW - COVID-19

KW - Real-Time Polymerase Chain Reaction

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KW - Viral Load

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ER -

Communication: Comparison of Respiratory Specimens for the Detection of SARS-CoV-2

Abstract

Bibliographical note

Keywords

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