Cognitive decline in association with hyposmia in idiopathic rapid eye movement sleep behavior disorder: a prospective 2-year follow-up study

C. Shin, J. Y. Lee, Y. K. Kim, H. Nam, E. J. Yoon, S. A. Shin, H. J. Kim, B. Jeon

Research output: Contribution to journalArticle

Abstract

Background and purpose: The aim was to analyze the characteristics and progression of cognitive dysfunction in non-demented idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with baseline olfactory function. Methods: From a prospective polysomnography-confirmed iRBD cohort, 25 patients (16 patients in 2-year follow-up) and 13 normal controls were included. Initial and 2-year follow-up cognitive functions were analyzed with olfactory function and 18F-fluorinated-N-3-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)-nortropane (18F-FP-CIT) uptake in deep nuclei initially. Results: Idiopathic RBD patients had impaired attention, memory and executive function compared to controls. Baseline cognitive tests were comparable between the iRBD subgroups with and without hyposmia. 18F-FP-CIT uptake tended to be lower in the hyposmic group than in the normosmic group. The olfactory test score was positively correlated with amygdala uptake in iRBD patients (P = 0.027). After 2 years, visuospatial and verbal memory dysfunction worsened more in hyposmics than in normosmics. Lower initial olfactory test score was associated with more severe declines in verbal memory function. Conclusions: Hyposmia may be a predictive sign of cognitive decline in iRBD patients.

Original languageEnglish
Pages (from-to)1417-1420
Number of pages4
JournalEuropean Journal of Neurology
Volume26
Issue number11
DOIs
StatePublished - 1 Nov 2019

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REM Sleep Behavior Disorder
Nortropanes
Polysomnography
Executive Function
Amygdala
Cognition
Cognitive Dysfunction

Keywords

  • REM sleep behavior disorder
  • cohort study
  • mild cognitive impairment
  • positron emission tomography

Cite this

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title = "Cognitive decline in association with hyposmia in idiopathic rapid eye movement sleep behavior disorder: a prospective 2-year follow-up study",
abstract = "Background and purpose: The aim was to analyze the characteristics and progression of cognitive dysfunction in non-demented idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with baseline olfactory function. Methods: From a prospective polysomnography-confirmed iRBD cohort, 25 patients (16 patients in 2-year follow-up) and 13 normal controls were included. Initial and 2-year follow-up cognitive functions were analyzed with olfactory function and 18F-fluorinated-N-3-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)-nortropane (18F-FP-CIT) uptake in deep nuclei initially. Results: Idiopathic RBD patients had impaired attention, memory and executive function compared to controls. Baseline cognitive tests were comparable between the iRBD subgroups with and without hyposmia. 18F-FP-CIT uptake tended to be lower in the hyposmic group than in the normosmic group. The olfactory test score was positively correlated with amygdala uptake in iRBD patients (P = 0.027). After 2 years, visuospatial and verbal memory dysfunction worsened more in hyposmics than in normosmics. Lower initial olfactory test score was associated with more severe declines in verbal memory function. Conclusions: Hyposmia may be a predictive sign of cognitive decline in iRBD patients.",
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author = "C. Shin and Lee, {J. Y.} and Kim, {Y. K.} and H. Nam and Yoon, {E. J.} and Shin, {S. A.} and Kim, {H. J.} and B. Jeon",
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T1 - Cognitive decline in association with hyposmia in idiopathic rapid eye movement sleep behavior disorder

T2 - a prospective 2-year follow-up study

AU - Shin, C.

AU - Lee, J. Y.

AU - Kim, Y. K.

AU - Nam, H.

AU - Yoon, E. J.

AU - Shin, S. A.

AU - Kim, H. J.

AU - Jeon, B.

PY - 2019/11/1

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N2 - Background and purpose: The aim was to analyze the characteristics and progression of cognitive dysfunction in non-demented idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with baseline olfactory function. Methods: From a prospective polysomnography-confirmed iRBD cohort, 25 patients (16 patients in 2-year follow-up) and 13 normal controls were included. Initial and 2-year follow-up cognitive functions were analyzed with olfactory function and 18F-fluorinated-N-3-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)-nortropane (18F-FP-CIT) uptake in deep nuclei initially. Results: Idiopathic RBD patients had impaired attention, memory and executive function compared to controls. Baseline cognitive tests were comparable between the iRBD subgroups with and without hyposmia. 18F-FP-CIT uptake tended to be lower in the hyposmic group than in the normosmic group. The olfactory test score was positively correlated with amygdala uptake in iRBD patients (P = 0.027). After 2 years, visuospatial and verbal memory dysfunction worsened more in hyposmics than in normosmics. Lower initial olfactory test score was associated with more severe declines in verbal memory function. Conclusions: Hyposmia may be a predictive sign of cognitive decline in iRBD patients.

AB - Background and purpose: The aim was to analyze the characteristics and progression of cognitive dysfunction in non-demented idiopathic rapid eye movement sleep behavior disorder (iRBD) patients with baseline olfactory function. Methods: From a prospective polysomnography-confirmed iRBD cohort, 25 patients (16 patients in 2-year follow-up) and 13 normal controls were included. Initial and 2-year follow-up cognitive functions were analyzed with olfactory function and 18F-fluorinated-N-3-fluoropropyl-2β-carboxymethoxy-3β-(4-iodophenyl)-nortropane (18F-FP-CIT) uptake in deep nuclei initially. Results: Idiopathic RBD patients had impaired attention, memory and executive function compared to controls. Baseline cognitive tests were comparable between the iRBD subgroups with and without hyposmia. 18F-FP-CIT uptake tended to be lower in the hyposmic group than in the normosmic group. The olfactory test score was positively correlated with amygdala uptake in iRBD patients (P = 0.027). After 2 years, visuospatial and verbal memory dysfunction worsened more in hyposmics than in normosmics. Lower initial olfactory test score was associated with more severe declines in verbal memory function. Conclusions: Hyposmia may be a predictive sign of cognitive decline in iRBD patients.

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