Cobalt-Catalyzed C-F Bond Borylation of Aryl Fluorides

Soobin Lim, Dalnim Song, Seungwon Jeon, Youngsuk Kim, Hyunseok Kim, Sanghee Lee, Hyungdo Cho, Byung Chul Lee, Sang Eun Kim, Kimoon Kim, Eunsung Lee

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A mild and practical cobalt-catalyzed defluoroborylation of fluoroarenes is presented for the first time. The method permits straightforward functionalization of fluoroarenes, with high selectivity for borylation of C-F over C-H bonds, and a tolerance for aerobic conditions. Furthermore, two-step 18 F-fluorination was achieved for expanding the scope of 18 F-positron emission tomography probes.

Original languageEnglish
Pages (from-to)7249-7252
Number of pages4
JournalOrganic Letters
Volume20
Issue number22
DOIs
StatePublished - 16 Nov 2018

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Fluorination
Positron emission tomography
fluorination
Halogenation
Cobalt
Fluorides
Positron-Emission Tomography
fluorides
positrons
cobalt
tomography
selectivity
probes

Cite this

Lim, S., Song, D., Jeon, S., Kim, Y., Kim, H., Lee, S., ... Lee, E. (2018). Cobalt-Catalyzed C-F Bond Borylation of Aryl Fluorides. Organic Letters, 20(22), 7249-7252. https://doi.org/10.1021/acs.orglett.8b03167
Lim, Soobin ; Song, Dalnim ; Jeon, Seungwon ; Kim, Youngsuk ; Kim, Hyunseok ; Lee, Sanghee ; Cho, Hyungdo ; Lee, Byung Chul ; Kim, Sang Eun ; Kim, Kimoon ; Lee, Eunsung. / Cobalt-Catalyzed C-F Bond Borylation of Aryl Fluorides. In: Organic Letters. 2018 ; Vol. 20, No. 22. pp. 7249-7252.
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Lim, S, Song, D, Jeon, S, Kim, Y, Kim, H, Lee, S, Cho, H, Lee, BC, Kim, SE, Kim, K & Lee, E 2018, 'Cobalt-Catalyzed C-F Bond Borylation of Aryl Fluorides', Organic Letters, vol. 20, no. 22, pp. 7249-7252. https://doi.org/10.1021/acs.orglett.8b03167

Cobalt-Catalyzed C-F Bond Borylation of Aryl Fluorides. / Lim, Soobin; Song, Dalnim; Jeon, Seungwon; Kim, Youngsuk; Kim, Hyunseok; Lee, Sanghee; Cho, Hyungdo; Lee, Byung Chul; Kim, Sang Eun; Kim, Kimoon; Lee, Eunsung.

In: Organic Letters, Vol. 20, No. 22, 16.11.2018, p. 7249-7252.

Research output: Contribution to journalArticle

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AU - Lee, Sanghee

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Lim S, Song D, Jeon S, Kim Y, Kim H, Lee S et al. Cobalt-Catalyzed C-F Bond Borylation of Aryl Fluorides. Organic Letters. 2018 Nov 16;20(22):7249-7252. https://doi.org/10.1021/acs.orglett.8b03167