Clinicopathological significance of the lymphovascular invasion detected in specimens from radical retropubic prostatectomies

Myung Cheol Gil, In Ho Chang, Yong Jun Kim, Jin Kyu Oh, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee

Research output: Contribution to journalArticle

Abstract

Purpose: We tried to determine the clinicopathological significance of lymphovascular invasion (LVI) in patients who were treated for prostate cancer with radical retropubic prostatectomy. Materials and Methods: From November 2003 to June 2005, 165 patients underwent radical retropubic prostatectomy for clinically-localized prostate cancer at our institution. The results of the final pathologic analyses were reviewed. Results: Of the 165 total patients, foci of LVI were identified in 46 patients. LVI was associated with a higher preoperative serum Level of prostate-specific antigen (p=0.006), the Gleason score (p<0.0001), a higher weight of tumor volume (p<0.0001), a higher rate of capsular penetration (p< 0.0001), a higher rate of seminal vesicle involvement (p<0.0001), and a higher rate of a positive margin (p<0.0001). Conclusions: Since the pathological features of LVI appear to be associated with the other established features of more advanced prostate cancers, they may prove to be useful markers for predicting the prognosis of patients who undergo radical prostatectomy. Our findings support performing routine evaluation for LVI in radical prostatectomy specimens and its inclusion in the models for predicting the clinical outcome.

Original languageEnglish
Pages (from-to)757-761
Number of pages5
JournalKorean Journal of Urology
Volume47
Issue number7
DOIs
StatePublished - Jul 2006

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Prostatectomy
Prostatic Neoplasms
Neoplasm Grading
Seminal Vesicles
Prostate-Specific Antigen
Tumor Burden
Weights and Measures
Serum

Keywords

  • Lymphovascular invasion
  • Prostate cancer
  • Prostatectomy

Cite this

Gil, Myung Cheol ; Chang, In Ho ; Kim, Yong Jun ; Oh, Jin Kyu ; Hong, Sung Kyu ; Byun, Seok-Soo ; Lee, Sang Eun. / Clinicopathological significance of the lymphovascular invasion detected in specimens from radical retropubic prostatectomies. In: Korean Journal of Urology. 2006 ; Vol. 47, No. 7. pp. 757-761.
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abstract = "Purpose: We tried to determine the clinicopathological significance of lymphovascular invasion (LVI) in patients who were treated for prostate cancer with radical retropubic prostatectomy. Materials and Methods: From November 2003 to June 2005, 165 patients underwent radical retropubic prostatectomy for clinically-localized prostate cancer at our institution. The results of the final pathologic analyses were reviewed. Results: Of the 165 total patients, foci of LVI were identified in 46 patients. LVI was associated with a higher preoperative serum Level of prostate-specific antigen (p=0.006), the Gleason score (p<0.0001), a higher weight of tumor volume (p<0.0001), a higher rate of capsular penetration (p< 0.0001), a higher rate of seminal vesicle involvement (p<0.0001), and a higher rate of a positive margin (p<0.0001). Conclusions: Since the pathological features of LVI appear to be associated with the other established features of more advanced prostate cancers, they may prove to be useful markers for predicting the prognosis of patients who undergo radical prostatectomy. Our findings support performing routine evaluation for LVI in radical prostatectomy specimens and its inclusion in the models for predicting the clinical outcome.",
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Clinicopathological significance of the lymphovascular invasion detected in specimens from radical retropubic prostatectomies. / Gil, Myung Cheol; Chang, In Ho; Kim, Yong Jun; Oh, Jin Kyu; Hong, Sung Kyu; Byun, Seok-Soo; Lee, Sang Eun.

In: Korean Journal of Urology, Vol. 47, No. 7, 07.2006, p. 757-761.

Research output: Contribution to journalArticle

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AU - Byun, Seok-Soo

AU - Lee, Sang Eun

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