Clinical utility of real-time ultrasound-multimodality fusion guidance for percutaneous biopsy of focal liver lesions

Su Joa Ahn, Jeong Min Lee, Won Chang, Sang Min Lee, Hyo Jin Kang, Hyun kyung Yang, Joon Koo Han

Research output: Contribution to journalArticle

6 Scopus citations


Objectives: To prospectively evaluate the clinical value of real-time ultrasonography (US)—computed tomography (CT)/magnetic resonance imaging (MRI) fusion imaging for percutaneous needle biopsy of focal liver lesions (FLLs), and to compare its biopsy success rate with that of conventional US-guided biopsy in a propensity-score matched group. Methods: This study was approved by our Institutional Review Board and informed consent was obtained from all patients enrolled in the prospective study group. Ninety patients referred to the Department of Radiology for percutaneous biopsy of FLLs were enrolled in this study. Tumor visibility, attainment of a safe access route, and technical feasibility were assessed on conventional US first and later on real-time fusion imaging by one of four abdominal radiologists. Thereafter, differences in scores between real-time fusion imaging and conventional US were determined. In addition, overall diagnostic success rates of a real-time fusion imaging-guided biopsy group and a propensity-score matched, conventional US-guided biopsy group, consisting of 100 patients used as historical control, were compared. Results: With real-time fusion imaging, tumor visibility, attainment of a safe access route, and operator's technical feasibility were significantly improved compared with conventional US (P <.001). In addition, all invisible (n = 13) and not feasible (n = 10) FLLs on conventional US became visible and feasible for percutaneous US-guided biopsy after applying the fusion system. The diagnostic success rate of real-time fusion-guided biopsy was 94.4% (85/90), which was significantly better than that obtained with the conventional US-guided biopsy (94.4% vs. 83%, P <.03), with reduced biopsy procedure times (7.1 ± 3.5 vs. 9.7 ± 2.8, P <.02). Conclusions: Real-time US-CT/MR fusion imaging guidance was able to provide clinical value for percutaneous needle biopsy of FLLs by improving the diagnostic success rate of biopsy and by reducing procedure time.

Original languageEnglish
Pages (from-to)76-83
Number of pages8
JournalEuropean Journal of Radiology
StatePublished - Jun 2018


  • Biopsy
  • Feasibility
  • Focal liver lesion
  • Fusion imaging
  • Ultrasonography
  • Visibility

Cite this