Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis

Sang Hwan Lee, Jin Ho Hwang, Dong Hyun Kim, Young Ho So, Jihong Park, Soo Buem Cho, Jeong Eun Kim, Young Jae Kim, Saebeom Hur, Hwan Jun Jae

Research output: Contribution to journalArticle

Abstract

Purpose: This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods: This study included patients (n = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis (n = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis (n = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results: There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P =.00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P <.01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). Conclusion: Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. Level of Evidence: 4, Case series.

Original languageEnglish
Pages (from-to)1530-1536
Number of pages7
JournalCardioVascular and Interventional Radiology
Volume42
Issue number11
DOIs
StatePublished - 1 Nov 2019

Fingerprint

Knee Osteoarthritis
Chronic Pain
Osteoarthritis
Knee
Visual Analog Scale
Pain
Cilastatin
Body Mass Index
Therapeutics
Retrospective Studies

Keywords

  • Abnormal neovessels
  • Embolisation
  • Knee pain
  • Osteoarthritis

Cite this

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title = "Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain: Mild-to-Moderate Versus Severe Knee Osteoarthritis",
abstract = "Purpose: This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods: This study included patients (n = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis (n = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis (n = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results: There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P =.00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P <.01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). Conclusion: Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. Level of Evidence: 4, Case series.",
keywords = "Abnormal neovessels, Embolisation, Knee pain, Osteoarthritis",
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Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain : Mild-to-Moderate Versus Severe Knee Osteoarthritis. / Lee, Sang Hwan; Hwang, Jin Ho; Kim, Dong Hyun; So, Young Ho; Park, Jihong; Cho, Soo Buem; Kim, Jeong Eun; Kim, Young Jae; Hur, Saebeom; Jae, Hwan Jun.

In: CardioVascular and Interventional Radiology, Vol. 42, No. 11, 01.11.2019, p. 1530-1536.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical Outcomes of Transcatheter Arterial Embolisation for Chronic Knee Pain

T2 - Mild-to-Moderate Versus Severe Knee Osteoarthritis

AU - Lee, Sang Hwan

AU - Hwang, Jin Ho

AU - Kim, Dong Hyun

AU - So, Young Ho

AU - Park, Jihong

AU - Cho, Soo Buem

AU - Kim, Jeong Eun

AU - Kim, Young Jae

AU - Hur, Saebeom

AU - Jae, Hwan Jun

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Purpose: This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods: This study included patients (n = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis (n = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis (n = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results: There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P =.00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P <.01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). Conclusion: Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. Level of Evidence: 4, Case series.

AB - Purpose: This retrospective study was conducted to compare the clinical outcomes of transcatheter arterial embolisation for chronic knee pain in patients with mild-to-moderate versus severe knee osteoarthritis. Materials and Methods: This study included patients (n = 41) who were refractory to conservative treatments and who underwent transcatheter arterial embolisation using imipenem/cilastatin sodium between June 2017 and July 2018. A total of 71 knees, including 30 bilateral cases, were treated and categorised into two groups according to the Kellgren–Lawrence grade: mild-to-moderate osteoarthritis (n = 59, Kellgren–Lawrence grade 1–3) and severe osteoarthritis (n = 12, Kellgren–Lawrence grade 4). The clinical outcomes were measured by the visual analogue scale score. Results: There were no significant differences in age, body mass index or baseline visual analogue scale scores between the two groups. The mean visual analogue scale scores in the mild-to-moderate osteoarthritis group were significantly decreased at 1 day, 1 week, 1 month, 3 months, and 6-months (5.5 at baseline vs. 3.2, 3.1, 2.9, 2.2, and 1.9, after treatment; all P =.00). These improvements were maintained at a mean of 10 ± 3 months (range 6–19 months) post-treatment. The visual analogue scale scores were significantly decreased in the severe osteoarthritis group for 1 month post-treatment (6.3 at baseline vs. 4.1, 4.1, and 4.4 at 1 day, 1 week, and 1 month; all P <.01). However, a decrease in pain was not statistically significant from 3 to 6 months (5.4 and 5.9 at 3 months and 6 months, respectively). Conclusion: Transcatheter arterial embolisation effectively relieved pain in patients with mild-to-moderate osteoarthritis. In patients with severe osteoarthritis, pain severity decreased for 1 month but gradually increased to the initial severity score within 3 months. Level of Evidence: 4, Case series.

KW - Abnormal neovessels

KW - Embolisation

KW - Knee pain

KW - Osteoarthritis

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U2 - 10.1007/s00270-019-02289-4

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