Clinical manifestations of patients with CASPR2 antibodies

Jun Sang Sunwoo, Soon Tae Lee, Jung Ick Byun, Jangsup Moon, Jung Won Shin, Da Eun Jeong, Gun Hee Lee, Seong Ho Jeong, Yong Won Shin, Keun Hwa Jung, Doo Young Lee, Daejong Jeon, Ki Young Jung, Manho Kim, Sang Kun Lee, Kon Chu

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Contactin-associated protein-like 2 (CASPR2) is one of the target antigens of voltage-gated potassium channels (VGKC) complex antibodies. There has been relatively little information in the literature regarding CASPR2 autoimmunity, especially in Asian population. We investigated the presence of CASPR2 antibodies in patients with presumed autoimmune neurological disorders and described the clinical features, laboratory findings, and responses to immunotherapy. Five patients were identified to be positive for CASPR2 antibodies. The results obtained here suggested that CASPR2 antibodies might be the possible cause of epilepsy even in the absence of typical features of limbic encephalitis and that immunotherapy could provide a favorable outcome.

Original languageEnglish
Pages (from-to)17-22
Number of pages6
JournalJournal of Neuroimmunology
Volume281
DOIs
StatePublished - 15 Apr 2015

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Contactins
Antibodies
Proteins
Immunotherapy
Limbic Encephalitis
Voltage-Gated Potassium Channels
Nervous System Diseases
Autoimmunity
Epilepsy
Antigens
Population

Keywords

  • CASPR2
  • Epilepsy
  • Immunotherapy
  • Neuromyotonia

Cite this

Sunwoo, Jun Sang ; Lee, Soon Tae ; Byun, Jung Ick ; Moon, Jangsup ; Shin, Jung Won ; Jeong, Da Eun ; Lee, Gun Hee ; Jeong, Seong Ho ; Shin, Yong Won ; Jung, Keun Hwa ; Lee, Doo Young ; Jeon, Daejong ; Jung, Ki Young ; Kim, Manho ; Lee, Sang Kun ; Chu, Kon. / Clinical manifestations of patients with CASPR2 antibodies. In: Journal of Neuroimmunology. 2015 ; Vol. 281. pp. 17-22.
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abstract = "Contactin-associated protein-like 2 (CASPR2) is one of the target antigens of voltage-gated potassium channels (VGKC) complex antibodies. There has been relatively little information in the literature regarding CASPR2 autoimmunity, especially in Asian population. We investigated the presence of CASPR2 antibodies in patients with presumed autoimmune neurological disorders and described the clinical features, laboratory findings, and responses to immunotherapy. Five patients were identified to be positive for CASPR2 antibodies. The results obtained here suggested that CASPR2 antibodies might be the possible cause of epilepsy even in the absence of typical features of limbic encephalitis and that immunotherapy could provide a favorable outcome.",
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Sunwoo, JS, Lee, ST, Byun, JI, Moon, J, Shin, JW, Jeong, DE, Lee, GH, Jeong, SH, Shin, YW, Jung, KH, Lee, DY, Jeon, D, Jung, KY, Kim, M, Lee, SK & Chu, K 2015, 'Clinical manifestations of patients with CASPR2 antibodies', Journal of Neuroimmunology, vol. 281, pp. 17-22. https://doi.org/10.1016/j.jneuroim.2015.03.005

Clinical manifestations of patients with CASPR2 antibodies. / Sunwoo, Jun Sang; Lee, Soon Tae; Byun, Jung Ick; Moon, Jangsup; Shin, Jung Won; Jeong, Da Eun; Lee, Gun Hee; Jeong, Seong Ho; Shin, Yong Won; Jung, Keun Hwa; Lee, Doo Young; Jeon, Daejong; Jung, Ki Young; Kim, Manho; Lee, Sang Kun; Chu, Kon.

In: Journal of Neuroimmunology, Vol. 281, 15.04.2015, p. 17-22.

Research output: Contribution to journalArticle

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AU - Sunwoo, Jun Sang

AU - Lee, Soon Tae

AU - Byun, Jung Ick

AU - Moon, Jangsup

AU - Shin, Jung Won

AU - Jeong, Da Eun

AU - Lee, Gun Hee

AU - Jeong, Seong Ho

AU - Shin, Yong Won

AU - Jung, Keun Hwa

AU - Lee, Doo Young

AU - Jeon, Daejong

AU - Jung, Ki Young

AU - Kim, Manho

AU - Lee, Sang Kun

AU - Chu, Kon

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