Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy

Do Hyeon Park; Chan Mi Lee; Euijin Chang; Chang Kyung Kang; Wan Beom Park; Nam Joong Kim; Pyoeng Gyun Choe; Myoung don Oh

doi:10.3346/jkms.2022.37.e238

Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy

Do Hyeon Park, Chan Mi Lee, Euijin Chang, Chang Kyung Kang, Wan Beom Park, Nam Joong Kim, Pyoeng Gyun Choe, Myoung don Oh

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has not been evaluated. We conducted retrospective propensity score-matched case-control study of 233 COVID-19 patients with moderate to severe illnesses who required oxygen therapy and evaluated whether empirical antibiotic therapy could improve clinical outcomes. Empirical antibiotic therapy did not improve clinical outcomes including length of stay, days with oxygen requirement, the proportion of patients with increased oxygen demand, the proportion of patients who required mechanical ventilation, and overall mortality. This finding implies that routine administration of antibiotics for the treatment of COVID-19 is not essential and should be restricted.

Original language	English
Article number	e238
Journal	Journal of Korean Medical Science
Volume	37
Issue number	29
DOIs	https://doi.org/10.3346/jkms.2022.37.e238
State	Published - 2022

Bibliographical note

Publisher Copyright:
© 2022. The Korean Academy of Medical Sciences. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Keywords

Antibiotics
Antimicrobial Stewardship
Coronavirus Disease 2019

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10.3346/jkms.2022.37.e238

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title = "Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy",

abstract = "Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has not been evaluated. We conducted retrospective propensity score-matched case-control study of 233 COVID-19 patients with moderate to severe illnesses who required oxygen therapy and evaluated whether empirical antibiotic therapy could improve clinical outcomes. Empirical antibiotic therapy did not improve clinical outcomes including length of stay, days with oxygen requirement, the proportion of patients with increased oxygen demand, the proportion of patients who required mechanical ventilation, and overall mortality. This finding implies that routine administration of antibiotics for the treatment of COVID-19 is not essential and should be restricted.",

keywords = "Antibiotics, Antimicrobial Stewardship, Coronavirus Disease 2019",

author = "Park, {Do Hyeon} and Lee, {Chan Mi} and Euijin Chang and Kang, {Chang Kyung} and Park, {Wan Beom} and Kim, {Nam Joong} and Choe, {Pyoeng Gyun} and Oh, {Myoung don}",

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year = "2022",

doi = "10.3346/jkms.2022.37.e238",

language = "English",

volume = "37",

journal = "Journal of Korean Medical Science",

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TY - JOUR

T1 - Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy

AU - Park, Do Hyeon

AU - Lee, Chan Mi

AU - Chang, Euijin

AU - Kang, Chang Kyung

AU - Park, Wan Beom

AU - Kim, Nam Joong

AU - Choe, Pyoeng Gyun

AU - Oh, Myoung don

N1 - Publisher Copyright: © 2022. The Korean Academy of Medical Sciences. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

PY - 2022

Y1 - 2022

N2 - Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has not been evaluated. We conducted retrospective propensity score-matched case-control study of 233 COVID-19 patients with moderate to severe illnesses who required oxygen therapy and evaluated whether empirical antibiotic therapy could improve clinical outcomes. Empirical antibiotic therapy did not improve clinical outcomes including length of stay, days with oxygen requirement, the proportion of patients with increased oxygen demand, the proportion of patients who required mechanical ventilation, and overall mortality. This finding implies that routine administration of antibiotics for the treatment of COVID-19 is not essential and should be restricted.

AB - Despite the low prevalence of secondary bacterial infection in coronavirus disease 2019 (COVID-19) patients, most of them were administered antibiotic therapy empirically. However, the prognostic impact of empirical antibiotic therapy has not been evaluated. We conducted retrospective propensity score-matched case-control study of 233 COVID-19 patients with moderate to severe illnesses who required oxygen therapy and evaluated whether empirical antibiotic therapy could improve clinical outcomes. Empirical antibiotic therapy did not improve clinical outcomes including length of stay, days with oxygen requirement, the proportion of patients with increased oxygen demand, the proportion of patients who required mechanical ventilation, and overall mortality. This finding implies that routine administration of antibiotics for the treatment of COVID-19 is not essential and should be restricted.

KW - Antibiotics

KW - Antimicrobial Stewardship

KW - Coronavirus Disease 2019

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M3 - Article

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SN - 1011-8934

VL - 37

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

IS - 29

M1 - e238

ER -

Clinical Impact of Empirical Antibiotic Therapy in Patients With Coronavirus Disease 2019 Requiring Oxygen Therapy

Abstract

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