Clinical features of Waldenstrom macroglobulinemia in Korea

Soo Mee Bang, Sook Ryun Park, Se Hoon Park, Eun Kyung Cho, Sung-Soo Yoon, Dong Bok Shin, Jae Hoon Lee, Seonyang Park, Byoung Kook Kim, Noe Kyeong Kim

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Background: Waldenstrom macroglobulinemia (WM) is a lymphoproliferative disorder characterized by monoclonal IgM. Its rarity makes it difficult to know the clinical manifestations and outcomes of patients with WM. Methods: The clinical records of 13 patients diagnosed with WM between 1983 and 2003 were reviewed, and 12 patients were eligible. Results: The median age was 57 years (range, 40 to 85), and the male to female ratio was 2. B symptoms and hyperviscosity requiring plasmapheresis existed in 5 and 4 patients, respectively, at the time of diagnosis. Hepatomegaly and splenomegaly were detected in 5 and 3 patients, respectively. Sites of extranodal involvement were bone (3) and lung (1) in 3 patients. The peripheral neuropathy was complicated in 3 patients. (Ed note: check this sentence.) Cryoglobulin was checked in 6 patients and it was detected in 3 of them. The median concentration of serum IgM was 4.2 g/dL (0.7-6.2). The median albumin, hemoglobin, WBC, and platelet levels were 2.8 g/dL, 8 g/dL, 5,400/μL, and 138,000/μL, respectively. One patient had transitional cell carcinoma concomitantly, and one patient developed small cell lung cancer. Of the 11 patients receiving chemotherapy (7-chlorambucil, 2-melphalan, 1-cyclophosphamide, 1-CHOP), 4 patients showed the objective responses including 2 complete remissions, but they all ultimately relapsed. The response rate of second-line therapy was 14% (1/7). After a median follow-up of 20 months, 3 patients were still alive with disease. The median overall and progression-free survival were 24 months (95% confidence interval (CI): 5-43) and 24 months (95% CI: 8-40), respectively. Conclusion: The initial high levels of serum IgM and severe anemia reflect a lack of suspicion of WM at the early stage. Careful suspicion and proper diagnostic approaches will allow more patients to show an improved outcome.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalKorean Journal of Internal Medicine
Volume19
Issue number3
DOIs
StatePublished - 1 Jan 2004

Fingerprint

Waldenstrom Macroglobulinemia
Korea
Immunoglobulin M
Confidence Intervals
Cryoglobulins
Chlorambucil
Melphalan
Hepatomegaly
Plasmapheresis
Lymphoproliferative Disorders
Transitional Cell Carcinoma
Splenomegaly
Small Cell Lung Carcinoma
Peripheral Nervous System Diseases
Serum
Cyclophosphamide

Keywords

  • IgM
  • Lymphoproliferative disorder
  • Waldenstrom macroglobulinemia

Cite this

Bang, Soo Mee ; Park, Sook Ryun ; Park, Se Hoon ; Cho, Eun Kyung ; Yoon, Sung-Soo ; Shin, Dong Bok ; Lee, Jae Hoon ; Park, Seonyang ; Kim, Byoung Kook ; Kim, Noe Kyeong. / Clinical features of Waldenstrom macroglobulinemia in Korea. In: Korean Journal of Internal Medicine. 2004 ; Vol. 19, No. 3. pp. 137-140.
@article{0b2d8b342b8b4e30ab053541d094eec8,
title = "Clinical features of Waldenstrom macroglobulinemia in Korea",
abstract = "Background: Waldenstrom macroglobulinemia (WM) is a lymphoproliferative disorder characterized by monoclonal IgM. Its rarity makes it difficult to know the clinical manifestations and outcomes of patients with WM. Methods: The clinical records of 13 patients diagnosed with WM between 1983 and 2003 were reviewed, and 12 patients were eligible. Results: The median age was 57 years (range, 40 to 85), and the male to female ratio was 2. B symptoms and hyperviscosity requiring plasmapheresis existed in 5 and 4 patients, respectively, at the time of diagnosis. Hepatomegaly and splenomegaly were detected in 5 and 3 patients, respectively. Sites of extranodal involvement were bone (3) and lung (1) in 3 patients. The peripheral neuropathy was complicated in 3 patients. (Ed note: check this sentence.) Cryoglobulin was checked in 6 patients and it was detected in 3 of them. The median concentration of serum IgM was 4.2 g/dL (0.7-6.2). The median albumin, hemoglobin, WBC, and platelet levels were 2.8 g/dL, 8 g/dL, 5,400/μL, and 138,000/μL, respectively. One patient had transitional cell carcinoma concomitantly, and one patient developed small cell lung cancer. Of the 11 patients receiving chemotherapy (7-chlorambucil, 2-melphalan, 1-cyclophosphamide, 1-CHOP), 4 patients showed the objective responses including 2 complete remissions, but they all ultimately relapsed. The response rate of second-line therapy was 14{\%} (1/7). After a median follow-up of 20 months, 3 patients were still alive with disease. The median overall and progression-free survival were 24 months (95{\%} confidence interval (CI): 5-43) and 24 months (95{\%} CI: 8-40), respectively. Conclusion: The initial high levels of serum IgM and severe anemia reflect a lack of suspicion of WM at the early stage. Careful suspicion and proper diagnostic approaches will allow more patients to show an improved outcome.",
keywords = "IgM, Lymphoproliferative disorder, Waldenstrom macroglobulinemia",
author = "Bang, {Soo Mee} and Park, {Sook Ryun} and Park, {Se Hoon} and Cho, {Eun Kyung} and Sung-Soo Yoon and Shin, {Dong Bok} and Lee, {Jae Hoon} and Seonyang Park and Kim, {Byoung Kook} and Kim, {Noe Kyeong}",
year = "2004",
month = "1",
day = "1",
doi = "10.3904/kjim.2004.19.3.137",
language = "English",
volume = "19",
pages = "137--140",
journal = "The Korean journal of internal medicine",
issn = "1226-3303",
publisher = "Korean Association of Internal Medicine",
number = "3",

}

Bang, SM, Park, SR, Park, SH, Cho, EK, Yoon, S-S, Shin, DB, Lee, JH, Park, S, Kim, BK & Kim, NK 2004, 'Clinical features of Waldenstrom macroglobulinemia in Korea', Korean Journal of Internal Medicine, vol. 19, no. 3, pp. 137-140. https://doi.org/10.3904/kjim.2004.19.3.137

Clinical features of Waldenstrom macroglobulinemia in Korea. / Bang, Soo Mee; Park, Sook Ryun; Park, Se Hoon; Cho, Eun Kyung; Yoon, Sung-Soo; Shin, Dong Bok; Lee, Jae Hoon; Park, Seonyang; Kim, Byoung Kook; Kim, Noe Kyeong.

In: Korean Journal of Internal Medicine, Vol. 19, No. 3, 01.01.2004, p. 137-140.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Clinical features of Waldenstrom macroglobulinemia in Korea

AU - Bang, Soo Mee

AU - Park, Sook Ryun

AU - Park, Se Hoon

AU - Cho, Eun Kyung

AU - Yoon, Sung-Soo

AU - Shin, Dong Bok

AU - Lee, Jae Hoon

AU - Park, Seonyang

AU - Kim, Byoung Kook

AU - Kim, Noe Kyeong

PY - 2004/1/1

Y1 - 2004/1/1

N2 - Background: Waldenstrom macroglobulinemia (WM) is a lymphoproliferative disorder characterized by monoclonal IgM. Its rarity makes it difficult to know the clinical manifestations and outcomes of patients with WM. Methods: The clinical records of 13 patients diagnosed with WM between 1983 and 2003 were reviewed, and 12 patients were eligible. Results: The median age was 57 years (range, 40 to 85), and the male to female ratio was 2. B symptoms and hyperviscosity requiring plasmapheresis existed in 5 and 4 patients, respectively, at the time of diagnosis. Hepatomegaly and splenomegaly were detected in 5 and 3 patients, respectively. Sites of extranodal involvement were bone (3) and lung (1) in 3 patients. The peripheral neuropathy was complicated in 3 patients. (Ed note: check this sentence.) Cryoglobulin was checked in 6 patients and it was detected in 3 of them. The median concentration of serum IgM was 4.2 g/dL (0.7-6.2). The median albumin, hemoglobin, WBC, and platelet levels were 2.8 g/dL, 8 g/dL, 5,400/μL, and 138,000/μL, respectively. One patient had transitional cell carcinoma concomitantly, and one patient developed small cell lung cancer. Of the 11 patients receiving chemotherapy (7-chlorambucil, 2-melphalan, 1-cyclophosphamide, 1-CHOP), 4 patients showed the objective responses including 2 complete remissions, but they all ultimately relapsed. The response rate of second-line therapy was 14% (1/7). After a median follow-up of 20 months, 3 patients were still alive with disease. The median overall and progression-free survival were 24 months (95% confidence interval (CI): 5-43) and 24 months (95% CI: 8-40), respectively. Conclusion: The initial high levels of serum IgM and severe anemia reflect a lack of suspicion of WM at the early stage. Careful suspicion and proper diagnostic approaches will allow more patients to show an improved outcome.

AB - Background: Waldenstrom macroglobulinemia (WM) is a lymphoproliferative disorder characterized by monoclonal IgM. Its rarity makes it difficult to know the clinical manifestations and outcomes of patients with WM. Methods: The clinical records of 13 patients diagnosed with WM between 1983 and 2003 were reviewed, and 12 patients were eligible. Results: The median age was 57 years (range, 40 to 85), and the male to female ratio was 2. B symptoms and hyperviscosity requiring plasmapheresis existed in 5 and 4 patients, respectively, at the time of diagnosis. Hepatomegaly and splenomegaly were detected in 5 and 3 patients, respectively. Sites of extranodal involvement were bone (3) and lung (1) in 3 patients. The peripheral neuropathy was complicated in 3 patients. (Ed note: check this sentence.) Cryoglobulin was checked in 6 patients and it was detected in 3 of them. The median concentration of serum IgM was 4.2 g/dL (0.7-6.2). The median albumin, hemoglobin, WBC, and platelet levels were 2.8 g/dL, 8 g/dL, 5,400/μL, and 138,000/μL, respectively. One patient had transitional cell carcinoma concomitantly, and one patient developed small cell lung cancer. Of the 11 patients receiving chemotherapy (7-chlorambucil, 2-melphalan, 1-cyclophosphamide, 1-CHOP), 4 patients showed the objective responses including 2 complete remissions, but they all ultimately relapsed. The response rate of second-line therapy was 14% (1/7). After a median follow-up of 20 months, 3 patients were still alive with disease. The median overall and progression-free survival were 24 months (95% confidence interval (CI): 5-43) and 24 months (95% CI: 8-40), respectively. Conclusion: The initial high levels of serum IgM and severe anemia reflect a lack of suspicion of WM at the early stage. Careful suspicion and proper diagnostic approaches will allow more patients to show an improved outcome.

KW - IgM

KW - Lymphoproliferative disorder

KW - Waldenstrom macroglobulinemia

UR - http://www.scopus.com/inward/record.url?scp=16544394495&partnerID=8YFLogxK

U2 - 10.3904/kjim.2004.19.3.137

DO - 10.3904/kjim.2004.19.3.137

M3 - Review article

C2 - 15481603

AN - SCOPUS:16544394495

VL - 19

SP - 137

EP - 140

JO - The Korean journal of internal medicine

JF - The Korean journal of internal medicine

SN - 1226-3303

IS - 3

ER -