Clinical features of 20 patients with curatively resected biliary neuroendocrine tumours

Jaihwan Kim, Woo Jin Lee, Sang Hyub Lee, Kyoung Bun Lee, Ji Kon Ryu, Yong Tae Kim, Sun Whe Kim, Yong Bum Yoon, Jin Hyeok Hwang, Ho Seong Han, Sang Myung Woo, Sang Jae Park

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27 Scopus citations


Background: Neuroendocrine tumours very rarely occur in the biliary tract; information about them is limited. Aims: To present the clinical characteristics and prognosis of curatively resected biliary neuroendocrine tumours. Methods: Review of medical records dated between 2000 and 2010 of 20 patients from three medical centres with biliary neuroendocrine tumour based on curative resection. Results: Based on the World Health Organization 2010 classification, five and one patients had neuroendocrine tumour grades 1 and 2, seven had neuroendocrine carcinoma, and seven were diagnosed with mixed adenoneuroendocrine carcinoma. The locations were the following: seven in the gallbladder, four in the extrahepatic bile duct, and nine in the ampulla of Vater. Lymph node and hepatic metastases were noted in 11 and 4 patients, respectively. Fourteen patients experienced recurrence; most had recurrence in the liver. Patients with neuroendocrine tumour grade 1 had a lower rate of recurrence compared to others (p= 0.001). The median disease-free and overall survival times were 5.8 (0.4-53.6) and 13.7 (1.9-102.1) months for all four subtypes. However, the median disease free and overall survival rates of neuroendocrine tumours were significantly longer than those of neuroendocrine carcinomas or mixed adenoneuroendocrine carcinoma. Conclusions: Patients with biliary neuroendocrine tumour showed extremely different clinical outcomes according to histopathologic subtypes by World Health Organization 2010 classification.

Original languageEnglish
Pages (from-to)965-970
Number of pages6
JournalDigestive and Liver Disease
Issue number12
StatePublished - 1 Dec 2011


  • Biliary tract
  • Carcinoid tumour
  • Neuroendocrine carcinoma
  • Neuroendocrine tumour

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