Clinical features and pathological characteristics of amygdala enlargement in mesial temporal lobe epilepsy

Dong Wook Kim, Sang Kun Lee, Chun Kee Chung, Young Cho Koh, Geeyoung Choe, So Dug Lim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Although the hippocampus is considered an important site of seizures in mesial temporal lobe epilepsy (mTLE), the amygdala may also have a significant role. Amygdala enlargement is occasionally found in patients with mTLE, and volumetric detection of amygdala enlargement has been documented in "image-negative" patients with TLE. However, only limited data have been reported on the clinical features, surgical outcomes, and pathological characteristics in patients with mTLE with amygdala enlargement. We recruited 12 patients who had undergone surgical treatment for refractory epilepsy with radiological evidence of amygdala enlargement, and 11 became seizure free. All patients showed homogenously increased amygdala volumes on MRI without enhancement and underwent surgical treatment for mTLE. Pathology results revealed that eight patients had focal cortical dysplasia (FCD), two had ganglioglioma, one had oligodendroglioma, and one had astrocytoma. The clinical features and MRI findings were largely indistinguishable between the patients with brain tumors and those with FCD, but the patients with brain tumors tended to be younger at the time of seizure onset. Our study shows that surgical treatment of epilepsy in patients with amygdala enlargement usually has a favorable outcome. FCD was the most frequent pathological diagnosis in these patients. However, a brain tumor should be considered in the differential diagnosis, especially in young patients, because it is often difficult to differentiate FCD from a brain tumor on radiological features.

Original languageEnglish
Pages (from-to)509-512
Number of pages4
JournalJournal of Clinical Neuroscience
Volume19
Issue number4
DOIs
StatePublished - 1 Apr 2012

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Temporal Lobe Epilepsy
Amygdala
Malformations of Cortical Development
Brain Neoplasms
Seizures
Epilepsy
Ganglioglioma
Oligodendroglioma
Astrocytoma
Hippocampus
Differential Diagnosis
Therapeutics
Pathology

Keywords

  • Amygdala
  • Cortical dysplasia
  • Temporal lobe epilepsy

Cite this

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Clinical features and pathological characteristics of amygdala enlargement in mesial temporal lobe epilepsy. / Kim, Dong Wook; Lee, Sang Kun; Chung, Chun Kee; Koh, Young Cho; Choe, Geeyoung; Lim, So Dug.

In: Journal of Clinical Neuroscience, Vol. 19, No. 4, 01.04.2012, p. 509-512.

Research output: Contribution to journalArticle

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