Clinical experience of modified diffusion-weighted imaging protocol for lesion detection in transient global amnesia: An 8-year large-scale clinical study

Jungeun Kim, Yooseok Kwon, Youngsoon Yang, Il Mi Jang, Younghee Chang, Young Ho Park, Jae Won Jang, Jae Hyoung Kim, Sang Yun Kim

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

BACKGROUND AND PURPOSE: The detection rate of typical transient global amnesia (TGA) lesions on diffusion-weighted imaging (DWI) can be improved, up to 85% with optimal DWI parameters and imaging time. There is limited evidence that these findings are similar to those observed in large-scale consecutive patients with TGA in clinical practice. METHODS: Patients with clinically diagnosed TGA underwent magnetic resonance imaging studies, consecutively, with three sets of DWI parameters (standard clinical DWI protocols, the TGA DWI protocol I and the TGA DWI protocol II) in which the resolution, slice thickness, and the time interval between symptom onset of DWI were varied over an 8-year period. RESULTS: TGA lesion detection rates were up to 88% with a modified TGA DWI protocol. The lesion detection rate was the highest using TGA DWI protocol I, with b = 3,000 s/mm2, a slice thickness of 3 mm, and performed on the third day after symptom onset, and TGA DWI protocol II, with b = 2,000 s/mm2 and a slice thickness of 2 mm. CONCLUSIONS: A modified TGA DWI protocols for detecting TGA lesions are useful in large-scale clinical practice for confirming the diagnosis of TGA patients with clinical findings.

Original languageEnglish
Pages (from-to)331-337
Number of pages7
JournalJournal of Neuroimaging
Volume24
Issue number4
DOIs
StatePublished - 1 Jan 2014

Keywords

  • Clinical study
  • Diffusion-weighted imaging protocol
  • Transient global amnesia

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