Clinical efficacy of highly purified hMG versus recombinant FSH in IVF/ICSI cycles: A meta-analysis

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15 Citations (Scopus)

Abstract

Background/Aims: To compare the effectiveness of highly purified hMG (Menopur) with recombinant FSH (Gonal-F) in IVF/ICSI patients who underwent ovarian hyperstimulation with pituitary suppression. Methods: A literature search of the National Library of Medicine and the National Institutes of Health (PubMed), Medline and Cochrane Controlled Trials Register was performed using the key words 'highly purified hMG' and 'recombinant FSH.' Only prospective randomized controlled trials were included when they compared IVF/ICSI outcomes after administration of Menopur versus Gonal-F. Five studies met the inclusion criteria and were reviewed. The primary outcome measure was ongoing pregnancy/live birth. Results: Ongoing pregnancy rate per started cycle (RR: 1.10, 95% CI: 0.96-1.26) or per embryo transfer (RR: 1.13, 95% CI: 0.99-1.29), as well as live birth rate per embryo transfer (RR: 1.14, 95% CI: 0.98-1.33), is similar between the Menopur and the Gonal-F group. Conclusion: The combined data presented in this meta-analysis do not support a clinical superiority of Gonal-F over Menopur.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalGynecologic and Obstetric Investigation
Volume70
Issue number2
DOIs
StatePublished - 1 Aug 2010

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Menotropins
Intracytoplasmic Sperm Injections
Meta-Analysis
Embryo Transfer
Live Birth
National Library of Medicine (U.S.)
Birth Rate
National Institutes of Health (U.S.)
Pregnancy Rate
PubMed
Randomized Controlled Trials
Outcome Assessment (Health Care)
Pregnancy
follitropin alfa

Keywords

  • Highly purified hMG
  • IVF
  • Meta-analysis
  • Pregnancy rate
  • Recombinant FSH

Cite this

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title = "Clinical efficacy of highly purified hMG versus recombinant FSH in IVF/ICSI cycles: A meta-analysis",
abstract = "Background/Aims: To compare the effectiveness of highly purified hMG (Menopur) with recombinant FSH (Gonal-F) in IVF/ICSI patients who underwent ovarian hyperstimulation with pituitary suppression. Methods: A literature search of the National Library of Medicine and the National Institutes of Health (PubMed), Medline and Cochrane Controlled Trials Register was performed using the key words 'highly purified hMG' and 'recombinant FSH.' Only prospective randomized controlled trials were included when they compared IVF/ICSI outcomes after administration of Menopur versus Gonal-F. Five studies met the inclusion criteria and were reviewed. The primary outcome measure was ongoing pregnancy/live birth. Results: Ongoing pregnancy rate per started cycle (RR: 1.10, 95{\%} CI: 0.96-1.26) or per embryo transfer (RR: 1.13, 95{\%} CI: 0.99-1.29), as well as live birth rate per embryo transfer (RR: 1.14, 95{\%} CI: 0.98-1.33), is similar between the Menopur and the Gonal-F group. Conclusion: The combined data presented in this meta-analysis do not support a clinical superiority of Gonal-F over Menopur.",
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author = "Jee, {Byung Chul} and Suh, {Chang Suk} and Kim, {Yong Beom} and Kim, {Seok Hyun} and Moon, {Shin Yong}",
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AU - Kim, Seok Hyun

AU - Moon, Shin Yong

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N2 - Background/Aims: To compare the effectiveness of highly purified hMG (Menopur) with recombinant FSH (Gonal-F) in IVF/ICSI patients who underwent ovarian hyperstimulation with pituitary suppression. Methods: A literature search of the National Library of Medicine and the National Institutes of Health (PubMed), Medline and Cochrane Controlled Trials Register was performed using the key words 'highly purified hMG' and 'recombinant FSH.' Only prospective randomized controlled trials were included when they compared IVF/ICSI outcomes after administration of Menopur versus Gonal-F. Five studies met the inclusion criteria and were reviewed. The primary outcome measure was ongoing pregnancy/live birth. Results: Ongoing pregnancy rate per started cycle (RR: 1.10, 95% CI: 0.96-1.26) or per embryo transfer (RR: 1.13, 95% CI: 0.99-1.29), as well as live birth rate per embryo transfer (RR: 1.14, 95% CI: 0.98-1.33), is similar between the Menopur and the Gonal-F group. Conclusion: The combined data presented in this meta-analysis do not support a clinical superiority of Gonal-F over Menopur.

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