Clinical batteries and biomarkers in the diagnosis of Parkinson’s disease

Claire Henchcliffe, Un Jung Kang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Parkinson’s disease (PD) remains a diagnosis that is made primarily upon clinical grounds, and there is, as yet, no definitive diagnostic laboratory test. Unfortunately, clinical diagnosis can be challenging, since signs and symptoms of PD overlap with other distinct neurological disorders and may be masked by symptomatic treatment. Moreover, PD has a heterogeneous presentation and insidious onset, which makes early diagnosis particularly susceptible to error. A valid diagnostic biomarker for PD would remove several roadblocks to improving patient outcomes. First, it would improve diagnostic accuracy. Second, it would allow earlier diagnosis, which is critically important if disease-modifying and/or neuroprotective approaches are available. Third, it would better define diagnostic subtypes, which would reduce heterogeneity of subjects for enrollment into PD research studies and might provide appropriate individualized therapeutic approaches (Kang 2009, Michell et al. 2004).

Original languageEnglish
Title of host publicationParkinson's Disease, Second Edition
PublisherCRC Press
Pages713-724
Number of pages12
ISBN (Electronic)9781439807156
ISBN (Print)9781439807149
DOIs
StatePublished - 1 Jan 2012

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    Henchcliffe, C., & Kang, U. J. (2012). Clinical batteries and biomarkers in the diagnosis of Parkinson’s disease. In Parkinson's Disease, Second Edition (pp. 713-724). CRC Press. https://doi.org/10.1201/b12948