Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness

Sung Wan Kim, Jung Jin Kim, Bong Ju Lee, Je Chun Yu, Kyu Young Lee, Seung Hee Won, Seung Hwan Lee, Seung Hyun Kim, Shi Hyun Kang, Euitae Kim, Ju Yeon Lee, Jae Min Kim, Young Chul Chung

Research output: Contribution to journalArticle

Abstract

Aim: This study investigated the clinical characteristics and psychosocial factors associated with depression in patients with early psychosis according to stage of illness. Methods: The present study includes patients who fulfil the DSM-5 criteria for schizophrenia spectrum and other psychotic disorders. Patients were divided into two groups according to illness stage (the acute stage of first-episode psychosis and stabilization phase of recent-onset psychosis). Clinically meaningful depression was defined as moderate or severe on the depression dimension of the Clinician-Rated Dimensions of Psychosis Symptom Severity scale in the DSM-5. Results: In total, 340 (207 first-episode and 133 recent-onset) patients were recruited in this study. Patients with comorbid depression were characterized by frequent suicidal ideation, a past suicide attempt, and lower scores on the Subjective Well-being Under Neuroleptics and Brief Resilience Scale in both groups. Long duration of untreated psychosis and higher scores on the Early Trauma Inventory Self Report were associated with depression in the acute stage of first-episode psychosis. In the stabilization phase of recent-onset psychosis group, a monthly income and scores for sexual desire and on the Family Adaptability and Cohesion Evaluation Scale-III were significantly lower in patients with depression than in those without depression. Conclusion: Comorbid depression was associated with high suicidality, lower quality of life and poor resilience in patients with first-episode and recent-onset psychosis. Depression was associated with factors that had been present before the initiation of treatment in patients with first-episode psychosis and with environmental factors in those in the stabilization phase.

Original languageEnglish
Pages (from-to)44-52
Number of pages9
JournalEarly Intervention in Psychiatry
Volume14
Issue number1
DOIs
StatePublished - 1 Feb 2020

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Psychotic Disorders
Depression
Psychology
Schizophrenia Spectrum and Other Psychotic Disorders
Suicidal Ideation
Self Report
Suicide
Antipsychotic Agents
Quality of Life
Equipment and Supplies
Wounds and Injuries

Keywords

  • cohort
  • depression
  • first-episode psychosis
  • schizophrenia
  • suicide

Cite this

Kim, Sung Wan ; Kim, Jung Jin ; Lee, Bong Ju ; Yu, Je Chun ; Lee, Kyu Young ; Won, Seung Hee ; Lee, Seung Hwan ; Kim, Seung Hyun ; Kang, Shi Hyun ; Kim, Euitae ; Lee, Ju Yeon ; Kim, Jae Min ; Chung, Young Chul. / Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness. In: Early Intervention in Psychiatry. 2020 ; Vol. 14, No. 1. pp. 44-52.
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title = "Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness",
abstract = "Aim: This study investigated the clinical characteristics and psychosocial factors associated with depression in patients with early psychosis according to stage of illness. Methods: The present study includes patients who fulfil the DSM-5 criteria for schizophrenia spectrum and other psychotic disorders. Patients were divided into two groups according to illness stage (the acute stage of first-episode psychosis and stabilization phase of recent-onset psychosis). Clinically meaningful depression was defined as moderate or severe on the depression dimension of the Clinician-Rated Dimensions of Psychosis Symptom Severity scale in the DSM-5. Results: In total, 340 (207 first-episode and 133 recent-onset) patients were recruited in this study. Patients with comorbid depression were characterized by frequent suicidal ideation, a past suicide attempt, and lower scores on the Subjective Well-being Under Neuroleptics and Brief Resilience Scale in both groups. Long duration of untreated psychosis and higher scores on the Early Trauma Inventory Self Report were associated with depression in the acute stage of first-episode psychosis. In the stabilization phase of recent-onset psychosis group, a monthly income and scores for sexual desire and on the Family Adaptability and Cohesion Evaluation Scale-III were significantly lower in patients with depression than in those without depression. Conclusion: Comorbid depression was associated with high suicidality, lower quality of life and poor resilience in patients with first-episode and recent-onset psychosis. Depression was associated with factors that had been present before the initiation of treatment in patients with first-episode psychosis and with environmental factors in those in the stabilization phase.",
keywords = "cohort, depression, first-episode psychosis, schizophrenia, suicide",
author = "Kim, {Sung Wan} and Kim, {Jung Jin} and Lee, {Bong Ju} and Yu, {Je Chun} and Lee, {Kyu Young} and Won, {Seung Hee} and Lee, {Seung Hwan} and Kim, {Seung Hyun} and Kang, {Shi Hyun} and Euitae Kim and Lee, {Ju Yeon} and Kim, {Jae Min} and Chung, {Young Chul}",
year = "2020",
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Kim, SW, Kim, JJ, Lee, BJ, Yu, JC, Lee, KY, Won, SH, Lee, SH, Kim, SH, Kang, SH, Kim, E, Lee, JY, Kim, JM & Chung, YC 2020, 'Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness', Early Intervention in Psychiatry, vol. 14, no. 1, pp. 44-52. https://doi.org/10.1111/eip.12806

Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness. / Kim, Sung Wan; Kim, Jung Jin; Lee, Bong Ju; Yu, Je Chun; Lee, Kyu Young; Won, Seung Hee; Lee, Seung Hwan; Kim, Seung Hyun; Kang, Shi Hyun; Kim, Euitae; Lee, Ju Yeon; Kim, Jae Min; Chung, Young Chul.

In: Early Intervention in Psychiatry, Vol. 14, No. 1, 01.02.2020, p. 44-52.

Research output: Contribution to journalArticle

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T1 - Clinical and psychosocial factors associated with depression in patients with psychosis according to stage of illness

AU - Kim, Sung Wan

AU - Kim, Jung Jin

AU - Lee, Bong Ju

AU - Yu, Je Chun

AU - Lee, Kyu Young

AU - Won, Seung Hee

AU - Lee, Seung Hwan

AU - Kim, Seung Hyun

AU - Kang, Shi Hyun

AU - Kim, Euitae

AU - Lee, Ju Yeon

AU - Kim, Jae Min

AU - Chung, Young Chul

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Aim: This study investigated the clinical characteristics and psychosocial factors associated with depression in patients with early psychosis according to stage of illness. Methods: The present study includes patients who fulfil the DSM-5 criteria for schizophrenia spectrum and other psychotic disorders. Patients were divided into two groups according to illness stage (the acute stage of first-episode psychosis and stabilization phase of recent-onset psychosis). Clinically meaningful depression was defined as moderate or severe on the depression dimension of the Clinician-Rated Dimensions of Psychosis Symptom Severity scale in the DSM-5. Results: In total, 340 (207 first-episode and 133 recent-onset) patients were recruited in this study. Patients with comorbid depression were characterized by frequent suicidal ideation, a past suicide attempt, and lower scores on the Subjective Well-being Under Neuroleptics and Brief Resilience Scale in both groups. Long duration of untreated psychosis and higher scores on the Early Trauma Inventory Self Report were associated with depression in the acute stage of first-episode psychosis. In the stabilization phase of recent-onset psychosis group, a monthly income and scores for sexual desire and on the Family Adaptability and Cohesion Evaluation Scale-III were significantly lower in patients with depression than in those without depression. Conclusion: Comorbid depression was associated with high suicidality, lower quality of life and poor resilience in patients with first-episode and recent-onset psychosis. Depression was associated with factors that had been present before the initiation of treatment in patients with first-episode psychosis and with environmental factors in those in the stabilization phase.

AB - Aim: This study investigated the clinical characteristics and psychosocial factors associated with depression in patients with early psychosis according to stage of illness. Methods: The present study includes patients who fulfil the DSM-5 criteria for schizophrenia spectrum and other psychotic disorders. Patients were divided into two groups according to illness stage (the acute stage of first-episode psychosis and stabilization phase of recent-onset psychosis). Clinically meaningful depression was defined as moderate or severe on the depression dimension of the Clinician-Rated Dimensions of Psychosis Symptom Severity scale in the DSM-5. Results: In total, 340 (207 first-episode and 133 recent-onset) patients were recruited in this study. Patients with comorbid depression were characterized by frequent suicidal ideation, a past suicide attempt, and lower scores on the Subjective Well-being Under Neuroleptics and Brief Resilience Scale in both groups. Long duration of untreated psychosis and higher scores on the Early Trauma Inventory Self Report were associated with depression in the acute stage of first-episode psychosis. In the stabilization phase of recent-onset psychosis group, a monthly income and scores for sexual desire and on the Family Adaptability and Cohesion Evaluation Scale-III were significantly lower in patients with depression than in those without depression. Conclusion: Comorbid depression was associated with high suicidality, lower quality of life and poor resilience in patients with first-episode and recent-onset psychosis. Depression was associated with factors that had been present before the initiation of treatment in patients with first-episode psychosis and with environmental factors in those in the stabilization phase.

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