Abstract

We aimed to compare the prognostic power of clinical parameters, biomarkers and imaging parameters in predicting cardiovascular outcome in asymptomatic healthy population. A total of 5,182 asymptomatic patients who visited Health Promotion Center at Seoul National University Bundang Hospital between January 2006 and September 2008 and had coronary computed tomography angiography were evaluated. All cardiovascular events including cardiac death, acute coronary syndrome and stroke were evaluated as outcome. In asymptomatic general Korean population, cardiovascular event was found in 1.3 % during median follow up period of 48 months. Various multivariate analyses including C-reactive protein, Framingham risk score (FRS), coronary artery calcium score and degree of coronary artery stenosis showed that FRS and degree of coronary artery stenosis were independent parameters for future adverse cardiovascular events in asymptomatic population (OR 1.068, 95 % CI 1.023-1.114, p = 0.003 for FRS, OR 1.041, 95 % CI 1.031-1.051, p≤0.001 for stenosis). The C-statistics of FRS, degree of stenosis and FRS with degree of stenosis were 0.72 (95 % CI 0.64-0.80), 0.80 (95 % CI 0.72-0.88) and 0.83 (95 % CI 0.75-0.91), respectively. Among the clinical parameters, biomarkers and imaging parameters of cardiovascular disease, both FRS and degree of coronary artery stenosis are independent parameters to predict adverse outcome in asymptomatic population.

Original languageEnglish
Pages (from-to)1595-1602
Number of pages8
JournalInternational Journal of Cardiovascular Imaging
Volume29
Issue number7
DOIs
StatePublished - 1 Oct 2013

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Coronary Stenosis
Pathologic Constriction
Population
Biomarkers
Acute Coronary Syndrome
Health Promotion
C-Reactive Protein
Coronary Vessels
Cardiovascular Diseases
Multivariate Analysis
Stroke
Calcium

Keywords

  • Cardiovascular disease
  • Computed tomography
  • Prognosis

Cite this

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title = "Clinical and imaging parameters to predict cardiovascular outcome in asymptomatic subjects",
abstract = "We aimed to compare the prognostic power of clinical parameters, biomarkers and imaging parameters in predicting cardiovascular outcome in asymptomatic healthy population. A total of 5,182 asymptomatic patients who visited Health Promotion Center at Seoul National University Bundang Hospital between January 2006 and September 2008 and had coronary computed tomography angiography were evaluated. All cardiovascular events including cardiac death, acute coronary syndrome and stroke were evaluated as outcome. In asymptomatic general Korean population, cardiovascular event was found in 1.3 {\%} during median follow up period of 48 months. Various multivariate analyses including C-reactive protein, Framingham risk score (FRS), coronary artery calcium score and degree of coronary artery stenosis showed that FRS and degree of coronary artery stenosis were independent parameters for future adverse cardiovascular events in asymptomatic population (OR 1.068, 95 {\%} CI 1.023-1.114, p = 0.003 for FRS, OR 1.041, 95 {\%} CI 1.031-1.051, p≤0.001 for stenosis). The C-statistics of FRS, degree of stenosis and FRS with degree of stenosis were 0.72 (95 {\%} CI 0.64-0.80), 0.80 (95 {\%} CI 0.72-0.88) and 0.83 (95 {\%} CI 0.75-0.91), respectively. Among the clinical parameters, biomarkers and imaging parameters of cardiovascular disease, both FRS and degree of coronary artery stenosis are independent parameters to predict adverse outcome in asymptomatic population.",
keywords = "Cardiovascular disease, Computed tomography, Prognosis",
author = "Park, {Hyo Eun} and Chun, {Eun Ju} and Sangil Choi and Seung-Pyo Lee and Yoon, {Chang Hwan} and Kim, {Hyung Kwan} and Taejin Youn and Yong-Jin Kim and Dong-Ju Choi and Sohn, {Dae Won} and Cho, {Goo Yeong}",
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T1 - Clinical and imaging parameters to predict cardiovascular outcome in asymptomatic subjects

AU - Park, Hyo Eun

AU - Chun, Eun Ju

AU - Choi, Sangil

AU - Lee, Seung-Pyo

AU - Yoon, Chang Hwan

AU - Kim, Hyung Kwan

AU - Youn, Taejin

AU - Kim, Yong-Jin

AU - Choi, Dong-Ju

AU - Sohn, Dae Won

AU - Cho, Goo Yeong

PY - 2013/10/1

Y1 - 2013/10/1

N2 - We aimed to compare the prognostic power of clinical parameters, biomarkers and imaging parameters in predicting cardiovascular outcome in asymptomatic healthy population. A total of 5,182 asymptomatic patients who visited Health Promotion Center at Seoul National University Bundang Hospital between January 2006 and September 2008 and had coronary computed tomography angiography were evaluated. All cardiovascular events including cardiac death, acute coronary syndrome and stroke were evaluated as outcome. In asymptomatic general Korean population, cardiovascular event was found in 1.3 % during median follow up period of 48 months. Various multivariate analyses including C-reactive protein, Framingham risk score (FRS), coronary artery calcium score and degree of coronary artery stenosis showed that FRS and degree of coronary artery stenosis were independent parameters for future adverse cardiovascular events in asymptomatic population (OR 1.068, 95 % CI 1.023-1.114, p = 0.003 for FRS, OR 1.041, 95 % CI 1.031-1.051, p≤0.001 for stenosis). The C-statistics of FRS, degree of stenosis and FRS with degree of stenosis were 0.72 (95 % CI 0.64-0.80), 0.80 (95 % CI 0.72-0.88) and 0.83 (95 % CI 0.75-0.91), respectively. Among the clinical parameters, biomarkers and imaging parameters of cardiovascular disease, both FRS and degree of coronary artery stenosis are independent parameters to predict adverse outcome in asymptomatic population.

AB - We aimed to compare the prognostic power of clinical parameters, biomarkers and imaging parameters in predicting cardiovascular outcome in asymptomatic healthy population. A total of 5,182 asymptomatic patients who visited Health Promotion Center at Seoul National University Bundang Hospital between January 2006 and September 2008 and had coronary computed tomography angiography were evaluated. All cardiovascular events including cardiac death, acute coronary syndrome and stroke were evaluated as outcome. In asymptomatic general Korean population, cardiovascular event was found in 1.3 % during median follow up period of 48 months. Various multivariate analyses including C-reactive protein, Framingham risk score (FRS), coronary artery calcium score and degree of coronary artery stenosis showed that FRS and degree of coronary artery stenosis were independent parameters for future adverse cardiovascular events in asymptomatic population (OR 1.068, 95 % CI 1.023-1.114, p = 0.003 for FRS, OR 1.041, 95 % CI 1.031-1.051, p≤0.001 for stenosis). The C-statistics of FRS, degree of stenosis and FRS with degree of stenosis were 0.72 (95 % CI 0.64-0.80), 0.80 (95 % CI 0.72-0.88) and 0.83 (95 % CI 0.75-0.91), respectively. Among the clinical parameters, biomarkers and imaging parameters of cardiovascular disease, both FRS and degree of coronary artery stenosis are independent parameters to predict adverse outcome in asymptomatic population.

KW - Cardiovascular disease

KW - Computed tomography

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