Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients: A randomized, controlled trial

Hyuck Hoon Kwon, Ji Young Yoon, Jong Soo Hong, JaeYoon Jung, Mi Sun Park, Dae Hun Suh

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Recent studies have suggested that dietary factors, specifically glycaemic load, may be involved in the pathogenesis of acne. The aim of this study was to determine the clinical and histological effects on acne lesions of a low glycaemic load diet. A total of 32 patients with mild to moderate acne were randomly assigned to either a low glycaemic load diet or a control group diet, and completed a 10-week, parallel dietary intervention trial. Results indicate successful lowering of the glycaemic load. Subjects within the low glycaemic group demonstrated significant clinical improvement in the number of both non-inflammatory and inflammatory acne lesions. Histopathological examination of skin samples revealed several characteristics, including reduced size of sebaceous glands, decreased inflammation, and reduced expression of sterol regulatory element-binding protein-1, and interleukin- 8 in the low glycaemic load group. A reduction in glycaemic load of the diet for 10 weeks resulted in improvements in acne.

Original languageEnglish
Pages (from-to)241-246
Number of pages6
JournalActa Dermato-Venereologica
Volume92
Issue number3
DOIs
StatePublished - 19 Apr 2012

Fingerprint

Acne Vulgaris
Randomized Controlled Trials
Diet
Therapeutics
Sterol Regulatory Element Binding Protein 1
Sebaceous Glands
Interleukin-8
Glycemic Load
Inflammation
Control Groups
Skin

Keywords

  • Acne
  • Diet
  • Epidemiology
  • Glycaemic load
  • IGF-1

Cite this

Kwon, Hyuck Hoon ; Yoon, Ji Young ; Hong, Jong Soo ; Jung, JaeYoon ; Park, Mi Sun ; Suh, Dae Hun. / Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients : A randomized, controlled trial. In: Acta Dermato-Venereologica. 2012 ; Vol. 92, No. 3. pp. 241-246.
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Clinical and histological effect of a low glycaemic load diet in treatment of acne vulgaris in Korean patients : A randomized, controlled trial. / Kwon, Hyuck Hoon; Yoon, Ji Young; Hong, Jong Soo; Jung, JaeYoon; Park, Mi Sun; Suh, Dae Hun.

In: Acta Dermato-Venereologica, Vol. 92, No. 3, 19.04.2012, p. 241-246.

Research output: Contribution to journalArticle

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