Circulating eosinophil and neutrophil counts correlate with disease severity in bullous pemphigoid

Seh Hyun Park, Si-Hyung Lee, Jong Hoon Kim, Soo Chan Kim

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by tissue-bound and circulating autoantibodies directed against BP180 and/or BP230 antigens. Various inflammatory cells are involved in the development of blister in BP. Objective: The aim of this study was to evaluate the correlation between peripheral leukocyte counts and BP severity. Methods: We retrospectively included 60 patients with BP, who had not been treated with systemic steroid at the time of blood sampling. The patients were classified into two groups, those with admission history (admission group) and those without admission history (non-Admission group). Disease severity was evaluated using three parameters: Admission history, initial steroid dosage, and modified version of a pemphigus scoring system. We evaluated the correlation between peripheral leukocyte counts and disease severity measured by the three parameters. Results: The admission group showed a significant increase in disease severity measured by initial steroid dosage and severity score compared with the non-Admission group. Additionally, the admission group had increased total leukocyte, eosinophil, and neutrophil counts. In the correlation study, the peripheral eosinophil and neutrophil counts showed positive correlation with BP severity evaluated by both initial steroid dosage and the pemphigus scoring system. Conclusion: Peripheral eosinophil and neutrophil counts can be used as a marker in predicting disease severity in patients with BP.

Original languageEnglish
Pages (from-to)544-549
Number of pages6
JournalAnnals of Dermatology
Volume30
Issue number5
DOIs
StatePublished - 1 Oct 2018

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Bullous Pemphigoid
Eosinophils
Neutrophils
Steroids
Pemphigus
History
Leukocyte Count
Blister
Autoantibodies
Leukocytes
Antigens

Keywords

  • Bullous pemphigoid
  • Eosinophil
  • Leukocyte
  • Neutrophil

Cite this

Park, Seh Hyun ; Lee, Si-Hyung ; Kim, Jong Hoon ; Kim, Soo Chan. / Circulating eosinophil and neutrophil counts correlate with disease severity in bullous pemphigoid. In: Annals of Dermatology. 2018 ; Vol. 30, No. 5. pp. 544-549.
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abstract = "Background: Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by tissue-bound and circulating autoantibodies directed against BP180 and/or BP230 antigens. Various inflammatory cells are involved in the development of blister in BP. Objective: The aim of this study was to evaluate the correlation between peripheral leukocyte counts and BP severity. Methods: We retrospectively included 60 patients with BP, who had not been treated with systemic steroid at the time of blood sampling. The patients were classified into two groups, those with admission history (admission group) and those without admission history (non-Admission group). Disease severity was evaluated using three parameters: Admission history, initial steroid dosage, and modified version of a pemphigus scoring system. We evaluated the correlation between peripheral leukocyte counts and disease severity measured by the three parameters. Results: The admission group showed a significant increase in disease severity measured by initial steroid dosage and severity score compared with the non-Admission group. Additionally, the admission group had increased total leukocyte, eosinophil, and neutrophil counts. In the correlation study, the peripheral eosinophil and neutrophil counts showed positive correlation with BP severity evaluated by both initial steroid dosage and the pemphigus scoring system. Conclusion: Peripheral eosinophil and neutrophil counts can be used as a marker in predicting disease severity in patients with BP.",
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Circulating eosinophil and neutrophil counts correlate with disease severity in bullous pemphigoid. / Park, Seh Hyun; Lee, Si-Hyung; Kim, Jong Hoon; Kim, Soo Chan.

In: Annals of Dermatology, Vol. 30, No. 5, 01.10.2018, p. 544-549.

Research output: Contribution to journalArticleResearchpeer-review

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