Choledochal cyst and associated malignant tumors in adults: A multicenter survey in South Korea

Seung Eun Lee, Jin Young Jang, Young Joo Lee, Dong Wook Choi, Woo Jung Lee, Baik Hwan Cho, Sun Whe Kim

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Objective: To determine the clinical features and clinical outcomes of Korean adults treated surgically for choledochal cyst. Design: Retrospective nationwide multicenter study. Setting: Fifteen university hospitals (tertiary care referral centers) located in all 7 Korean provinces. Patients: A total of 808 patients aged 18 years or older who underwent surgery for choledochal cyst from January 1, 1990, through December 31, 2007. Main Outcome Measures: Demographic information, surgical data, associated biliary malignant tumors, and factors predicting malignant tumors. Results: Type I was most common (499 [68.2%]) followed by type IVa (208 [28.4%]). Of 654 patients, anomalous pancreaticobiliary ductal union was identified in 467 patients (71.4%), 291 with the choledochal type (62.3%), 96 with the pancreatic type (20.6%), and 80 with the complextype (17.1%). Biliary tract malignant tumor was associated in 80 patients (9.9%); 40 had bile duct cancer (50.0%), 35 had gallbladder cancer (43.8%), 3 had periampullary cancer, and 2 had synchronous gallbladder and bile duct cancer. Twenty-two patients (26.3%) had a recurrence, with a median follow-up duration of 51.8 months. Factors predicting malignant tumor by univariate analysis were age more than 40 years, the absence of a gallstone, elevated carcinoembryonic antigen or cancer antigen 19-9 serum level, and the presence of anomalous pancreaticobiliary ductal union, and by multivariate analysis, an elevated cancer antigen 19-9 level. Conclusions: Associated biliary malignant tumor should always be considered in patients with choledochal cyst, especially in aged patients or patients with anomalous pancreaticobiliary ductal union or an elevated tumor marker level. Lifelong follow-up is needed even after complete cyst excision because of the risk of the development of a metachronous biliary malignant tumor.

Original languageEnglish
Pages (from-to)1178-1184
Number of pages7
JournalArchives of Surgery
Volume146
Issue number10
DOIs
StatePublished - 1 Oct 2011

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