Chlorhexidine sensitivity in staphylococci isolated from patients with central line-associated bloodstream infection

K. I. Jun, Y. Choi, K. Kwon, M. J. Shin, J. S. Park, K. H. Song, E. S. Kim, K. H. Park, S. I. Jung, S. H. Cheon, Y. S. Kim, N. R. Yoon, D. M. Kim, P. G. Choe, N. J. Kim, H. B. Kim

Research output: Contribution to journalArticle

Abstract

Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.

Original languageEnglish
Pages (from-to)276-279
Number of pages4
JournalJournal of Hospital Infection
Volume103
Issue number3
DOIs
StatePublished - 1 Nov 2019

Fingerprint

Chlorhexidine
Staphylococcus
Infection
2-Propanol
Microbial Sensitivity Tests
Korea
Intensive Care Units
Genes

Keywords

  • Central line-associated bloodstream infection
  • Chlorhexidine resistance
  • Minimum bactericidal concentration
  • Minimum inhibitory concentration
  • Staphylococcus aureus

Cite this

Jun, K. I. ; Choi, Y. ; Kwon, K. ; Shin, M. J. ; Park, J. S. ; Song, K. H. ; Kim, E. S. ; Park, K. H. ; Jung, S. I. ; Cheon, S. H. ; Kim, Y. S. ; Yoon, N. R. ; Kim, D. M. ; Choe, P. G. ; Kim, N. J. ; Kim, H. B. / Chlorhexidine sensitivity in staphylococci isolated from patients with central line-associated bloodstream infection. In: Journal of Hospital Infection. 2019 ; Vol. 103, No. 3. pp. 276-279.
@article{26ee8f7a23bd475c8bb0e443dc06e653,
title = "Chlorhexidine sensitivity in staphylococci isolated from patients with central line-associated bloodstream infection",
abstract = "Since 2011, 2{\%} chlorhexidine in 70{\%} isopropyl alcohol (2{\%} chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2{\%} chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.",
keywords = "Central line-associated bloodstream infection, Chlorhexidine resistance, Minimum bactericidal concentration, Minimum inhibitory concentration, Staphylococcus aureus",
author = "Jun, {K. I.} and Y. Choi and K. Kwon and Shin, {M. J.} and Park, {J. S.} and Song, {K. H.} and Kim, {E. S.} and Park, {K. H.} and Jung, {S. I.} and Cheon, {S. H.} and Kim, {Y. S.} and Yoon, {N. R.} and Kim, {D. M.} and Choe, {P. G.} and Kim, {N. J.} and Kim, {H. B.}",
year = "2019",
month = "11",
day = "1",
doi = "10.1016/j.jhin.2019.07.009",
language = "English",
volume = "103",
pages = "276--279",
journal = "Journal of Hospital Infection",
issn = "0195-6701",
publisher = "W.B. Saunders Ltd",
number = "3",

}

Chlorhexidine sensitivity in staphylococci isolated from patients with central line-associated bloodstream infection. / Jun, K. I.; Choi, Y.; Kwon, K.; Shin, M. J.; Park, J. S.; Song, K. H.; Kim, E. S.; Park, K. H.; Jung, S. I.; Cheon, S. H.; Kim, Y. S.; Yoon, N. R.; Kim, D. M.; Choe, P. G.; Kim, N. J.; Kim, H. B.

In: Journal of Hospital Infection, Vol. 103, No. 3, 01.11.2019, p. 276-279.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Chlorhexidine sensitivity in staphylococci isolated from patients with central line-associated bloodstream infection

AU - Jun, K. I.

AU - Choi, Y.

AU - Kwon, K.

AU - Shin, M. J.

AU - Park, J. S.

AU - Song, K. H.

AU - Kim, E. S.

AU - Park, K. H.

AU - Jung, S. I.

AU - Cheon, S. H.

AU - Kim, Y. S.

AU - Yoon, N. R.

AU - Kim, D. M.

AU - Choe, P. G.

AU - Kim, N. J.

AU - Kim, H. B.

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.

AB - Since 2011, 2% chlorhexidine in 70% isopropyl alcohol (2% chlorhexidine tincture) has been widely used in Korea. To investigate changes in chlorhexidine sensitivity of staphylococci causing central line-associated bloodstream infections, 264 blood culture isolates from adult patients treated in intensive care units of five university hospitals between 2008 and 2016 were analysed. We observed no significant changes in chlorhexidine minimum inhibitory and bactericidal concentrations, or in the prevalence of resistance-associated genes before and after introduction of 2% chlorhexidine tincture. Thus, there was no evidence of increased resistance to chlorhexidine in staphylococci causing central line-associated bloodstream infections.

KW - Central line-associated bloodstream infection

KW - Chlorhexidine resistance

KW - Minimum bactericidal concentration

KW - Minimum inhibitory concentration

KW - Staphylococcus aureus

UR - http://www.scopus.com/inward/record.url?scp=85071396578&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2019.07.009

DO - 10.1016/j.jhin.2019.07.009

M3 - Article

C2 - 31319094

AN - SCOPUS:85071396578

VL - 103

SP - 276

EP - 279

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

IS - 3

ER -