Characteristics of prostate cancer by opportunistic screening in Korean men with a prostate-specific antigen level less than 4.0 ng per milliliter

Hoon Choi, Seok Cho, Jae Hyun Bae, Sang Eun Lee, Sung Kyu Hong, Du Geon Moon, Jun Cheon, Seok-Soo Byun, Jae Young Park

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims/Objectives: We studied the detection rate of prostate cancer (PCa) among Korean men with a prostate-specific antigen (PSA) level of less than 4.0 ng/mL. Methods: A total of 1,680 men with PSA ≤4 ng/mL had a prostate biopsy from January 2004 to December 2014. The differences in clinical factors were analyzed and their independent predictive implications were evaluated. Results: PCa was diagnosed in 331 (19.6%) and 99 of these 331 cancers (14.9%) had a Gleason score of 7 or higher. The detection rate of PCa increased from 6.67% (≤0.5 ng/mL) to 20.36% (3.01-3.9 ng/mL). There were significant differences in age 65.7 vs. 62.1 years, prostate volume 33.4 vs. 38.2 g, PSA density 0.10 vs. 0.08 ng/mL/mL between men with and without PCa. On multivariable analysis, age and prostate volume were the best independent discriminative parameters. When comparing PCa patients with a Gleason score less than 6 to those with a 7 or higher, patients with a Gleason score 7 or higher were older (67.2 vs. 64.8 years). Conclusions: Even when the PSA level is less than 4 ng/mL, PCas, including high-grade cancers, were detected in a significant number of men. In this group, patients with PCa were older and had a smaller prostate volume and high-grade cancers were detected more frequently in older cancer patients.

Original languageEnglish
Pages (from-to)143-148
Number of pages6
JournalUrologia Internationalis
Volume99
Issue number2
DOIs
StatePublished - 1 Sep 2017

Fingerprint

Prostate-Specific Antigen
Early Detection of Cancer
Prostatic Neoplasms
Neoplasm Grading
Prostate
Neoplasms
Biopsy

Keywords

  • Biopsy
  • Prostate cancer
  • Prostate-specific antigen

Cite this

Choi, Hoon ; Cho, Seok ; Bae, Jae Hyun ; Lee, Sang Eun ; Hong, Sung Kyu ; Moon, Du Geon ; Cheon, Jun ; Byun, Seok-Soo ; Park, Jae Young. / Characteristics of prostate cancer by opportunistic screening in Korean men with a prostate-specific antigen level less than 4.0 ng per milliliter. In: Urologia Internationalis. 2017 ; Vol. 99, No. 2. pp. 143-148.
@article{245dab3ce5bd43afaa0de3599ec619d0,
title = "Characteristics of prostate cancer by opportunistic screening in Korean men with a prostate-specific antigen level less than 4.0 ng per milliliter",
abstract = "Background/Aims/Objectives: We studied the detection rate of prostate cancer (PCa) among Korean men with a prostate-specific antigen (PSA) level of less than 4.0 ng/mL. Methods: A total of 1,680 men with PSA ≤4 ng/mL had a prostate biopsy from January 2004 to December 2014. The differences in clinical factors were analyzed and their independent predictive implications were evaluated. Results: PCa was diagnosed in 331 (19.6{\%}) and 99 of these 331 cancers (14.9{\%}) had a Gleason score of 7 or higher. The detection rate of PCa increased from 6.67{\%} (≤0.5 ng/mL) to 20.36{\%} (3.01-3.9 ng/mL). There were significant differences in age 65.7 vs. 62.1 years, prostate volume 33.4 vs. 38.2 g, PSA density 0.10 vs. 0.08 ng/mL/mL between men with and without PCa. On multivariable analysis, age and prostate volume were the best independent discriminative parameters. When comparing PCa patients with a Gleason score less than 6 to those with a 7 or higher, patients with a Gleason score 7 or higher were older (67.2 vs. 64.8 years). Conclusions: Even when the PSA level is less than 4 ng/mL, PCas, including high-grade cancers, were detected in a significant number of men. In this group, patients with PCa were older and had a smaller prostate volume and high-grade cancers were detected more frequently in older cancer patients.",
keywords = "Biopsy, Prostate cancer, Prostate-specific antigen",
author = "Hoon Choi and Seok Cho and Bae, {Jae Hyun} and Lee, {Sang Eun} and Hong, {Sung Kyu} and Moon, {Du Geon} and Jun Cheon and Seok-Soo Byun and Park, {Jae Young}",
year = "2017",
month = "9",
day = "1",
doi = "10.1159/000454886",
language = "English",
volume = "99",
pages = "143--148",
journal = "Urologia Internationalis",
issn = "0042-1138",
publisher = "S. Karger AG",
number = "2",

}

Characteristics of prostate cancer by opportunistic screening in Korean men with a prostate-specific antigen level less than 4.0 ng per milliliter. / Choi, Hoon; Cho, Seok; Bae, Jae Hyun; Lee, Sang Eun; Hong, Sung Kyu; Moon, Du Geon; Cheon, Jun; Byun, Seok-Soo; Park, Jae Young.

In: Urologia Internationalis, Vol. 99, No. 2, 01.09.2017, p. 143-148.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Characteristics of prostate cancer by opportunistic screening in Korean men with a prostate-specific antigen level less than 4.0 ng per milliliter

AU - Choi, Hoon

AU - Cho, Seok

AU - Bae, Jae Hyun

AU - Lee, Sang Eun

AU - Hong, Sung Kyu

AU - Moon, Du Geon

AU - Cheon, Jun

AU - Byun, Seok-Soo

AU - Park, Jae Young

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Background/Aims/Objectives: We studied the detection rate of prostate cancer (PCa) among Korean men with a prostate-specific antigen (PSA) level of less than 4.0 ng/mL. Methods: A total of 1,680 men with PSA ≤4 ng/mL had a prostate biopsy from January 2004 to December 2014. The differences in clinical factors were analyzed and their independent predictive implications were evaluated. Results: PCa was diagnosed in 331 (19.6%) and 99 of these 331 cancers (14.9%) had a Gleason score of 7 or higher. The detection rate of PCa increased from 6.67% (≤0.5 ng/mL) to 20.36% (3.01-3.9 ng/mL). There were significant differences in age 65.7 vs. 62.1 years, prostate volume 33.4 vs. 38.2 g, PSA density 0.10 vs. 0.08 ng/mL/mL between men with and without PCa. On multivariable analysis, age and prostate volume were the best independent discriminative parameters. When comparing PCa patients with a Gleason score less than 6 to those with a 7 or higher, patients with a Gleason score 7 or higher were older (67.2 vs. 64.8 years). Conclusions: Even when the PSA level is less than 4 ng/mL, PCas, including high-grade cancers, were detected in a significant number of men. In this group, patients with PCa were older and had a smaller prostate volume and high-grade cancers were detected more frequently in older cancer patients.

AB - Background/Aims/Objectives: We studied the detection rate of prostate cancer (PCa) among Korean men with a prostate-specific antigen (PSA) level of less than 4.0 ng/mL. Methods: A total of 1,680 men with PSA ≤4 ng/mL had a prostate biopsy from January 2004 to December 2014. The differences in clinical factors were analyzed and their independent predictive implications were evaluated. Results: PCa was diagnosed in 331 (19.6%) and 99 of these 331 cancers (14.9%) had a Gleason score of 7 or higher. The detection rate of PCa increased from 6.67% (≤0.5 ng/mL) to 20.36% (3.01-3.9 ng/mL). There were significant differences in age 65.7 vs. 62.1 years, prostate volume 33.4 vs. 38.2 g, PSA density 0.10 vs. 0.08 ng/mL/mL between men with and without PCa. On multivariable analysis, age and prostate volume were the best independent discriminative parameters. When comparing PCa patients with a Gleason score less than 6 to those with a 7 or higher, patients with a Gleason score 7 or higher were older (67.2 vs. 64.8 years). Conclusions: Even when the PSA level is less than 4 ng/mL, PCas, including high-grade cancers, were detected in a significant number of men. In this group, patients with PCa were older and had a smaller prostate volume and high-grade cancers were detected more frequently in older cancer patients.

KW - Biopsy

KW - Prostate cancer

KW - Prostate-specific antigen

UR - http://www.scopus.com/inward/record.url?scp=85018468840&partnerID=8YFLogxK

U2 - 10.1159/000454886

DO - 10.1159/000454886

M3 - Article

C2 - 28395285

AN - SCOPUS:85018468840

VL - 99

SP - 143

EP - 148

JO - Urologia Internationalis

JF - Urologia Internationalis

SN - 0042-1138

IS - 2

ER -