Characteristic time scales of electroencephalograms of narcoleptic patients and healthy controls

Jong Won Kim, Hongbeom Shin, Eui Joong Kim, Young Jin Koo, Byunghun Choi, Kwangsuk Park, Do Un Jeong

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Abstract

Sleep electroencephalograms (EEGs) typically showed correlated fluctuations that became random-like oscillations beyond a characteristic time scale. To investigate this behavior quantitatively, the detrended fluctuation analysis (DFA) was applied to EEGs of 10 narcoleptic patients (22.0±4.0yrs; 6 males) and 8 healthy controls (24.0±2.0yrs; 5 males). The characteristic time scales of the narcoleptics and controls were estimated as 1.8±0.7 and 4.4±1.2s, respectively (significance level, p<0.01). We further performed DFA of the EEGs segmented into 30. s epochs and found that the DFA scaling exponents increased in deep sleep stages. These results were verified with power spectrum and auto-correlation analysis, and reproduced by a mathematical model. We thus concluded that characteristics of EEGs of narcoleptic patients could be differentiated from those of healthy subjects, suggesting a potential application of DFA in diagnosing narcolepsy.

Original languageEnglish
Pages (from-to)831-838
Number of pages8
JournalComputers in Biology and Medicine
Volume40
Issue number10
DOIs
StatePublished - 1 Oct 2010

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Electroencephalography
Narcolepsy
Sleep Stages
Power spectrum
Autocorrelation
Healthy Volunteers
Sleep
Theoretical Models
Mathematical models

Keywords

  • Characteristic time scale
  • Detrended fluctuation analysis
  • Electroencephalogram
  • Narcolepsy
  • Scaling exponent

Cite this

Kim, Jong Won ; Shin, Hongbeom ; Kim, Eui Joong ; Koo, Young Jin ; Choi, Byunghun ; Park, Kwangsuk ; Jeong, Do Un. / Characteristic time scales of electroencephalograms of narcoleptic patients and healthy controls. In: Computers in Biology and Medicine. 2010 ; Vol. 40, No. 10. pp. 831-838.
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Characteristic time scales of electroencephalograms of narcoleptic patients and healthy controls. / Kim, Jong Won; Shin, Hongbeom; Kim, Eui Joong; Koo, Young Jin; Choi, Byunghun; Park, Kwangsuk; Jeong, Do Un.

In: Computers in Biology and Medicine, Vol. 40, No. 10, 01.10.2010, p. 831-838.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Kim, Eui Joong

AU - Koo, Young Jin

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AU - Park, Kwangsuk

AU - Jeong, Do Un

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