Changes in the Etiology and Clinical Characteristics of Pediatric Infective Endocarditis in South Korea

Research output: Contribution to journalArticlepeer-review


Objective: Changes in the epidemiology, clinical manifestations, and outcomes of infective endocarditis (IE) have been reported in recent years. This study was performed to analyze changing trends in the etiology of IE in children in South Korea. Study design: A retrospective study of children with IE was conducted from 2 hospitals in Korea from 2004 to 2019. IE was defined according to the Modified Duke criteria. We analyzed the etiology and clinical outcome of 96 cases and compared the etiology with that during 1987-1997, as described in a previous study. Results: A total of 96 cases in 89 children satisfied the modified Duke criteria. The median age was 9.5 years. Preexisting structural heart diseases were identified in 81 cases (84.4%). Ten of the 15 cases with normal heart anatomy had a history of indwelling central venous catheters and underlying noncardiac conditions. Of the 72 identified organisms, common pathogens included Staphylococcus aureus, 24 (32.9%); viridans streptococci, 22 (30.2%); coagulase-negative staphylococci, 14 (19.2%); and Candida species, 7 (9.6). Sixty-three cases (66.7%) required surgical intervention, and the overall fatality rate was 7.9%. Compared with the period of 1987-1997, an increasing trend in the proportion of staphylococci as the etiology of IE in 2004-2019 was observed (26.7% vs. 51.8%, P = 0.029). In addition, S. aureus was associated with the high rate of developing complications (P < 0.05). Conclusion: In South Korea, Gram-positive cocci represent 85% of all etiologic agents of IE in children with an increasing trend in the proportion of staphylococci.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalPediatric Infectious Disease Journal
StatePublished - 1 Feb 2021


  • Duke criteria
  • Staphylococcus aureus
  • Viridans streptococci
  • children
  • infective endocarditis

Fingerprint Dive into the research topics of 'Changes in the Etiology and Clinical Characteristics of Pediatric Infective Endocarditis in South Korea'. Together they form a unique fingerprint.

Cite this