CCL28 cannot replace IgE for severity by objective SCORAD index in atopic dermatitis in children

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Recently, CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis. We studied the association between objectively observed lesions and the level of CCL28 in children patients. Methods: A total of 105 children patients were grouped by the objective Scoring Atopic Dermatitis index (SCORAD). Total IgE, specific IgE, complete blood count, and serum level of CCL28 were evaluated. Results: The mean age of the subjects was 5.3 (range, 0-12 years). The median SCORAD was 21.4 and consisted of mild 70%, moderate 25%, and severe 6% disease. There were no statistical differences among severity groups for CCL28 or for total IgE. Total IgE showed positive correlation with eosinophil count (r = 0.429, p < 0.01), and SCORAD (r = 0.210, p < 0.05). Conclusions: The disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE.

Original languageEnglish
Pages (from-to)1577-1580
Number of pages4
JournalClinical Laboratory
Volume61
Issue number10
DOIs
StatePublished - 1 Jan 2015

Fingerprint

CC Chemokines
Atopic Dermatitis
Immunoglobulin E
Blood Cell Count
Eosinophils
Blood
Serum

Keywords

  • CCL28
  • Children
  • IgE
  • Objective SCORAD
  • Severity

Cite this

@article{fe7deac6d4164898a135cf31c02d0ae5,
title = "CCL28 cannot replace IgE for severity by objective SCORAD index in atopic dermatitis in children",
abstract = "Background: Recently, CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis. We studied the association between objectively observed lesions and the level of CCL28 in children patients. Methods: A total of 105 children patients were grouped by the objective Scoring Atopic Dermatitis index (SCORAD). Total IgE, specific IgE, complete blood count, and serum level of CCL28 were evaluated. Results: The mean age of the subjects was 5.3 (range, 0-12 years). The median SCORAD was 21.4 and consisted of mild 70{\%}, moderate 25{\%}, and severe 6{\%} disease. There were no statistical differences among severity groups for CCL28 or for total IgE. Total IgE showed positive correlation with eosinophil count (r = 0.429, p < 0.01), and SCORAD (r = 0.210, p < 0.05). Conclusions: The disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE.",
keywords = "CCL28, Children, IgE, Objective SCORAD, Severity",
author = "Yoon, {Jong Hyun} and Youngwon Nam and Song, {Eun Young} and Roh, {Eun Youn} and Yoon, {Hyun Sun} and Sue Shin",
year = "2015",
month = "1",
day = "1",
doi = "10.7754/Clin.Lab.2015.150311",
language = "English",
volume = "61",
pages = "1577--1580",
journal = "Clinical laboratory",
issn = "1433-6510",
publisher = "Verlag Klinisches Labor GmbH",
number = "10",

}

TY - JOUR

T1 - CCL28 cannot replace IgE for severity by objective SCORAD index in atopic dermatitis in children

AU - Yoon, Jong Hyun

AU - Nam, Youngwon

AU - Song, Eun Young

AU - Roh, Eun Youn

AU - Yoon, Hyun Sun

AU - Shin, Sue

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: Recently, CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis. We studied the association between objectively observed lesions and the level of CCL28 in children patients. Methods: A total of 105 children patients were grouped by the objective Scoring Atopic Dermatitis index (SCORAD). Total IgE, specific IgE, complete blood count, and serum level of CCL28 were evaluated. Results: The mean age of the subjects was 5.3 (range, 0-12 years). The median SCORAD was 21.4 and consisted of mild 70%, moderate 25%, and severe 6% disease. There were no statistical differences among severity groups for CCL28 or for total IgE. Total IgE showed positive correlation with eosinophil count (r = 0.429, p < 0.01), and SCORAD (r = 0.210, p < 0.05). Conclusions: The disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE.

AB - Background: Recently, CC chemokine ligand28 (CCL28) has been reported as a severity marker in atopic dermatitis. We studied the association between objectively observed lesions and the level of CCL28 in children patients. Methods: A total of 105 children patients were grouped by the objective Scoring Atopic Dermatitis index (SCORAD). Total IgE, specific IgE, complete blood count, and serum level of CCL28 were evaluated. Results: The mean age of the subjects was 5.3 (range, 0-12 years). The median SCORAD was 21.4 and consisted of mild 70%, moderate 25%, and severe 6% disease. There were no statistical differences among severity groups for CCL28 or for total IgE. Total IgE showed positive correlation with eosinophil count (r = 0.429, p < 0.01), and SCORAD (r = 0.210, p < 0.05). Conclusions: The disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE.

KW - CCL28

KW - Children

KW - IgE

KW - Objective SCORAD

KW - Severity

UR - http://www.scopus.com/inward/record.url?scp=84948444548&partnerID=8YFLogxK

U2 - 10.7754/Clin.Lab.2015.150311

DO - 10.7754/Clin.Lab.2015.150311

M3 - Article

C2 - 26642722

AN - SCOPUS:84948444548

VL - 61

SP - 1577

EP - 1580

JO - Clinical laboratory

JF - Clinical laboratory

SN - 1433-6510

IS - 10

ER -