Cathepsin D levels are reduced in patients with preeclampsia in Korean population

Ho Yeon Kim, Maria Lee, Hye Won Kang, Chong Soo Moon

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Objectives: To compare the circulating levels of cathepsin D in preeclamptic and normotensive pregnancies. Design and methods: Fifty pregnant and 20 healthy non-pregnant patients were enrolled in this study. Of the 50 pregnant patients, 15 were preeclamptic and 35 patients were normotensive. Serum levels of soluble cathepsin D were measured with an enzyme-linked immunosorbent assay (ELISA) kit. Results: Cathepsin D levels were significantly lower in preeclamptic patients than normotensive pregnant patients (p= 0.033). The serum levels of cathepsin D in preeclamptic and non-pregnant healthy patients showed similar results. The serum levels of cathepsin D were not positively correlated with preeclampsia severity or the incidence of delivery of small for gestational age infants. Conclusions: We conclude that a reduced cathepsin D level is an important factor that may contribute to the pathogenesis of preeclampsia, possibly by inhibiting normal trophoblastic invasion. These results contribute to the understanding of this serious obstetric problem.

Original languageEnglish
Pages (from-to)1808-1811
Number of pages4
JournalClinical Biochemistry
Volume46
Issue number18
DOIs
StatePublished - 1 Dec 2013

Keywords

  • Cathepsin D
  • Preeclampsia

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