Body mass index influences prostate-specific antigen in men younger than 60 years of age

Yong June Kim, Byung Kuy Han, Sung Kyu Hong, Seok-Soo Byun, Wun Jae Kim, Sang Eun Lee

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objectives: Prostate-specific antigen (PSA) levels can be affected by many factors. Body mass index (BMI) is suspected to influence PSA levels, but the associations are controversial. The aim of this study was to examine whether PSA levels were affected by BMI and age in Koreans. Methods: We evaluated the association between BMI and PSA in a group of 8640 Korean men (aged 40-79 years) without prostate cancer who received a general health checkup. Eligible men were classified into age groups spanning 10 years. BMI was categorized as normal (BMI <22.9), overweight (BMI 23.0-24.9), obese (BMI 25.0-29.9), and very obese (BMI ≥30) according to the re-defined World Health Organization (WHO) criterion for the Asia Pacific Region. PSA levels were stratified by age and BMI category. Results: Prostate-specific antigen levels decreased with increasing BMI (P trend <0.001). However, the inverse correlations between PSA and BMI were significant only among men 40-59 years old (P trend <0.05, respectively). BMI showed no significant associations with PSA in 60-79 years old (P trend >0.05, respectively). Conclusions: Our study demonstrates that increased BMI is associated with decreased PSA levels only in men younger than 60 years of age. When determining whether to carry out prostate biopsy as part of early prostate cancer detection, obesity should be considered as a factor associated with reduced PSA in healthy young men (<60 years old) with marginal PSA levels.

Original languageEnglish
Pages (from-to)1009-1012
Number of pages4
JournalInternational Journal of Urology
Volume14
Issue number11
DOIs
StatePublished - 1 Nov 2007

Fingerprint

Prostate-Specific Antigen
Body Mass Index
Prostatic Neoplasms
Early Detection of Cancer
Prostate
Age Groups
Obesity
Biopsy
Health

Keywords

  • Age
  • Body mass index
  • Neoplasms
  • Prostate
  • Prostate-specific antigen

Cite this

Kim, Yong June ; Han, Byung Kuy ; Hong, Sung Kyu ; Byun, Seok-Soo ; Kim, Wun Jae ; Lee, Sang Eun. / Body mass index influences prostate-specific antigen in men younger than 60 years of age. In: International Journal of Urology. 2007 ; Vol. 14, No. 11. pp. 1009-1012.
@article{020a0be12f634d7abd007f64f999d2b0,
title = "Body mass index influences prostate-specific antigen in men younger than 60 years of age",
abstract = "Objectives: Prostate-specific antigen (PSA) levels can be affected by many factors. Body mass index (BMI) is suspected to influence PSA levels, but the associations are controversial. The aim of this study was to examine whether PSA levels were affected by BMI and age in Koreans. Methods: We evaluated the association between BMI and PSA in a group of 8640 Korean men (aged 40-79 years) without prostate cancer who received a general health checkup. Eligible men were classified into age groups spanning 10 years. BMI was categorized as normal (BMI <22.9), overweight (BMI 23.0-24.9), obese (BMI 25.0-29.9), and very obese (BMI ≥30) according to the re-defined World Health Organization (WHO) criterion for the Asia Pacific Region. PSA levels were stratified by age and BMI category. Results: Prostate-specific antigen levels decreased with increasing BMI (P trend <0.001). However, the inverse correlations between PSA and BMI were significant only among men 40-59 years old (P trend <0.05, respectively). BMI showed no significant associations with PSA in 60-79 years old (P trend >0.05, respectively). Conclusions: Our study demonstrates that increased BMI is associated with decreased PSA levels only in men younger than 60 years of age. When determining whether to carry out prostate biopsy as part of early prostate cancer detection, obesity should be considered as a factor associated with reduced PSA in healthy young men (<60 years old) with marginal PSA levels.",
keywords = "Age, Body mass index, Neoplasms, Prostate, Prostate-specific antigen",
author = "Kim, {Yong June} and Han, {Byung Kuy} and Hong, {Sung Kyu} and Seok-Soo Byun and Kim, {Wun Jae} and Lee, {Sang Eun}",
year = "2007",
month = "11",
day = "1",
doi = "10.1111/j.1442-2042.2007.01879.x",
language = "English",
volume = "14",
pages = "1009--1012",
journal = "International Journal of Urology",
issn = "0919-8172",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "11",

}

Body mass index influences prostate-specific antigen in men younger than 60 years of age. / Kim, Yong June; Han, Byung Kuy; Hong, Sung Kyu; Byun, Seok-Soo; Kim, Wun Jae; Lee, Sang Eun.

In: International Journal of Urology, Vol. 14, No. 11, 01.11.2007, p. 1009-1012.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Body mass index influences prostate-specific antigen in men younger than 60 years of age

AU - Kim, Yong June

AU - Han, Byung Kuy

AU - Hong, Sung Kyu

AU - Byun, Seok-Soo

AU - Kim, Wun Jae

AU - Lee, Sang Eun

PY - 2007/11/1

Y1 - 2007/11/1

N2 - Objectives: Prostate-specific antigen (PSA) levels can be affected by many factors. Body mass index (BMI) is suspected to influence PSA levels, but the associations are controversial. The aim of this study was to examine whether PSA levels were affected by BMI and age in Koreans. Methods: We evaluated the association between BMI and PSA in a group of 8640 Korean men (aged 40-79 years) without prostate cancer who received a general health checkup. Eligible men were classified into age groups spanning 10 years. BMI was categorized as normal (BMI <22.9), overweight (BMI 23.0-24.9), obese (BMI 25.0-29.9), and very obese (BMI ≥30) according to the re-defined World Health Organization (WHO) criterion for the Asia Pacific Region. PSA levels were stratified by age and BMI category. Results: Prostate-specific antigen levels decreased with increasing BMI (P trend <0.001). However, the inverse correlations between PSA and BMI were significant only among men 40-59 years old (P trend <0.05, respectively). BMI showed no significant associations with PSA in 60-79 years old (P trend >0.05, respectively). Conclusions: Our study demonstrates that increased BMI is associated with decreased PSA levels only in men younger than 60 years of age. When determining whether to carry out prostate biopsy as part of early prostate cancer detection, obesity should be considered as a factor associated with reduced PSA in healthy young men (<60 years old) with marginal PSA levels.

AB - Objectives: Prostate-specific antigen (PSA) levels can be affected by many factors. Body mass index (BMI) is suspected to influence PSA levels, but the associations are controversial. The aim of this study was to examine whether PSA levels were affected by BMI and age in Koreans. Methods: We evaluated the association between BMI and PSA in a group of 8640 Korean men (aged 40-79 years) without prostate cancer who received a general health checkup. Eligible men were classified into age groups spanning 10 years. BMI was categorized as normal (BMI <22.9), overweight (BMI 23.0-24.9), obese (BMI 25.0-29.9), and very obese (BMI ≥30) according to the re-defined World Health Organization (WHO) criterion for the Asia Pacific Region. PSA levels were stratified by age and BMI category. Results: Prostate-specific antigen levels decreased with increasing BMI (P trend <0.001). However, the inverse correlations between PSA and BMI were significant only among men 40-59 years old (P trend <0.05, respectively). BMI showed no significant associations with PSA in 60-79 years old (P trend >0.05, respectively). Conclusions: Our study demonstrates that increased BMI is associated with decreased PSA levels only in men younger than 60 years of age. When determining whether to carry out prostate biopsy as part of early prostate cancer detection, obesity should be considered as a factor associated with reduced PSA in healthy young men (<60 years old) with marginal PSA levels.

KW - Age

KW - Body mass index

KW - Neoplasms

KW - Prostate

KW - Prostate-specific antigen

UR - http://www.scopus.com/inward/record.url?scp=35449005925&partnerID=8YFLogxK

U2 - 10.1111/j.1442-2042.2007.01879.x

DO - 10.1111/j.1442-2042.2007.01879.x

M3 - Article

C2 - 17956528

AN - SCOPUS:35449005925

VL - 14

SP - 1009

EP - 1012

JO - International Journal of Urology

JF - International Journal of Urology

SN - 0919-8172

IS - 11

ER -