Bisphenols and thyroid hormone

Research output: Contribution to journalReview article

2 Scopus citations

Abstract

In recent decades, attention has been directed toward the effects of bisphenol A (BPA) on human health. BPA has estrogenic activity and is regarded as a representative endocrine disruptor. In addition, mounting evidence indicates that BPA can disrupt thyroid hormone and its action. This review examined human epidemiological studies to investigate the association between BPA exposure and thyroid hormone levels, and analyzed in vivo and in vitro experiments to identify the causal relationship and its mechanism of action. BPA is involved in thyroid hormone action not only as a thyroid hormone receptor antagonist, but also through several other mechanisms. Since the use of bisphenols other than BPA has recently increased, we also reviewed the effects of other bisphenols on thyroid hormone action.

Original languageEnglish
Pages (from-to)340-348
Number of pages9
JournalEndocrinology and Metabolism
Volume34
Issue number4
DOIs
StatePublished - 1 Dec 2019

Keywords

  • Bisphenol A
  • Endocrine disruptors
  • Receptors, thyroid hormone
  • Thyroid hormones

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