Biological Aging Parameters Can Be Improved After Autologous Adipose-Derived Stem Cell Injection

Hye Youn Son, Hahn Sol Bae, Youngsook Son, Sundong Kim, Hyun Sook Hong, Ji Ung Park

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Biological aging (BA) is a comprehensive assessment tool for elderly persons. The authors aimed to develop a rat model that can be used to assess BA by evaluating various blood, biochemical, and hormonal parameters and demonstrate that the intravenous administration of autologous adipose-derived stem cells (ADSCs) improves BA. Twelve elderly (aged 20 months) male Sprague-Dawley rats were used in this study and divided into 2 groups: autologous ADSC administration (n = 6) and saline administration (n = 6). The complete blood count, biochemical and hormonal parameters, and antioxidant potential were evaluated before harvesting the rat inguinal fat tissue and intravenous ADSC administration as well as at 1, 3, and 5 weeks after ADSC administration. Adipose-derived stem cells administration regulated blood content, biochemical parameters, renal function, and antioxidant enzymes in elderly rats. Furthermore, changes in several hormonal levels were identified in the ADSC administration group compared with the saline administration group. An assessment model of BA in elderly rats was successfully developed after the intravenous administration of autologous ADSCs. The authors suggest that intravenously injected ADSC treatment may be a valuable method to improve BA.

Original languageEnglish
Pages (from-to)652-658
Number of pages7
JournalThe Journal of craniofacial surgery
Volume30
Issue number3
DOIs
StatePublished - 1 May 2019

Fingerprint

Stem Cells
Injections
Intravenous Administration
Antioxidants
Blood Cell Count
Groin
Sprague Dawley Rats
Adipose Tissue
Fats
Kidney
Enzymes

Cite this

Son, Hye Youn ; Bae, Hahn Sol ; Son, Youngsook ; Kim, Sundong ; Hong, Hyun Sook ; Park, Ji Ung. / Biological Aging Parameters Can Be Improved After Autologous Adipose-Derived Stem Cell Injection. In: The Journal of craniofacial surgery. 2019 ; Vol. 30, No. 3. pp. 652-658.
@article{424c21d45eb140219fe4a560d32d39a1,
title = "Biological Aging Parameters Can Be Improved After Autologous Adipose-Derived Stem Cell Injection",
abstract = "Biological aging (BA) is a comprehensive assessment tool for elderly persons. The authors aimed to develop a rat model that can be used to assess BA by evaluating various blood, biochemical, and hormonal parameters and demonstrate that the intravenous administration of autologous adipose-derived stem cells (ADSCs) improves BA. Twelve elderly (aged 20 months) male Sprague-Dawley rats were used in this study and divided into 2 groups: autologous ADSC administration (n = 6) and saline administration (n = 6). The complete blood count, biochemical and hormonal parameters, and antioxidant potential were evaluated before harvesting the rat inguinal fat tissue and intravenous ADSC administration as well as at 1, 3, and 5 weeks after ADSC administration. Adipose-derived stem cells administration regulated blood content, biochemical parameters, renal function, and antioxidant enzymes in elderly rats. Furthermore, changes in several hormonal levels were identified in the ADSC administration group compared with the saline administration group. An assessment model of BA in elderly rats was successfully developed after the intravenous administration of autologous ADSCs. The authors suggest that intravenously injected ADSC treatment may be a valuable method to improve BA.",
author = "Son, {Hye Youn} and Bae, {Hahn Sol} and Youngsook Son and Sundong Kim and Hong, {Hyun Sook} and Park, {Ji Ung}",
year = "2019",
month = "5",
day = "1",
doi = "10.1097/SCS.0000000000004932",
language = "English",
volume = "30",
pages = "652--658",
journal = "Journal of Craniofacial Surgery",
issn = "1049-2275",
publisher = "Lippincott Williams and Wilkins Ltd.",
number = "3",

}

Biological Aging Parameters Can Be Improved After Autologous Adipose-Derived Stem Cell Injection. / Son, Hye Youn; Bae, Hahn Sol; Son, Youngsook; Kim, Sundong; Hong, Hyun Sook; Park, Ji Ung.

In: The Journal of craniofacial surgery, Vol. 30, No. 3, 01.05.2019, p. 652-658.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Biological Aging Parameters Can Be Improved After Autologous Adipose-Derived Stem Cell Injection

AU - Son, Hye Youn

AU - Bae, Hahn Sol

AU - Son, Youngsook

AU - Kim, Sundong

AU - Hong, Hyun Sook

AU - Park, Ji Ung

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Biological aging (BA) is a comprehensive assessment tool for elderly persons. The authors aimed to develop a rat model that can be used to assess BA by evaluating various blood, biochemical, and hormonal parameters and demonstrate that the intravenous administration of autologous adipose-derived stem cells (ADSCs) improves BA. Twelve elderly (aged 20 months) male Sprague-Dawley rats were used in this study and divided into 2 groups: autologous ADSC administration (n = 6) and saline administration (n = 6). The complete blood count, biochemical and hormonal parameters, and antioxidant potential were evaluated before harvesting the rat inguinal fat tissue and intravenous ADSC administration as well as at 1, 3, and 5 weeks after ADSC administration. Adipose-derived stem cells administration regulated blood content, biochemical parameters, renal function, and antioxidant enzymes in elderly rats. Furthermore, changes in several hormonal levels were identified in the ADSC administration group compared with the saline administration group. An assessment model of BA in elderly rats was successfully developed after the intravenous administration of autologous ADSCs. The authors suggest that intravenously injected ADSC treatment may be a valuable method to improve BA.

AB - Biological aging (BA) is a comprehensive assessment tool for elderly persons. The authors aimed to develop a rat model that can be used to assess BA by evaluating various blood, biochemical, and hormonal parameters and demonstrate that the intravenous administration of autologous adipose-derived stem cells (ADSCs) improves BA. Twelve elderly (aged 20 months) male Sprague-Dawley rats were used in this study and divided into 2 groups: autologous ADSC administration (n = 6) and saline administration (n = 6). The complete blood count, biochemical and hormonal parameters, and antioxidant potential were evaluated before harvesting the rat inguinal fat tissue and intravenous ADSC administration as well as at 1, 3, and 5 weeks after ADSC administration. Adipose-derived stem cells administration regulated blood content, biochemical parameters, renal function, and antioxidant enzymes in elderly rats. Furthermore, changes in several hormonal levels were identified in the ADSC administration group compared with the saline administration group. An assessment model of BA in elderly rats was successfully developed after the intravenous administration of autologous ADSCs. The authors suggest that intravenously injected ADSC treatment may be a valuable method to improve BA.

UR - http://www.scopus.com/inward/record.url?scp=85065469930&partnerID=8YFLogxK

U2 - 10.1097/SCS.0000000000004932

DO - 10.1097/SCS.0000000000004932

M3 - Article

VL - 30

SP - 652

EP - 658

JO - Journal of Craniofacial Surgery

JF - Journal of Craniofacial Surgery

SN - 1049-2275

IS - 3

ER -