Biocompatible surface coatings for silicone-based implants

Jiyeon Ham, Sunah Kang, Ji Ung Park, Yan Lee

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

Abstract

With the growing interest in beauty and antiaging, demands for plastic surgery are rapidly increasing worldwide. Breast augmentation is one of the most representative forms of plastic surgery accounting for 15% of all cosmetic surgical procedures. 1 Moreover, breast reconstruction is becoming increasingly important for patients who have had mastectomies to remove cancerous breast tissues. 2 In most cases, silicone-based bags filled with saline or silicone cohesive gel are used as the breast implants. 3 Both the silicone bags and the cohesive filling gels are made of poly(dimethylsiloxane) 1212(PDMS) with different crosslinking degrees (Fig. 40.1). PDMS has been used as the implantable materials due to its inert, malleable, and deformable characteristics. Although the breast tissue-like mechanical properties and the moderate price of the silicone implants generally satisfy the patients, infection during the surgical procedure and the limited biocompatibility of the silicone surface often induce dissatisfaction with severe side effects. Approximately 4.3%-20% of patients receive surgical intervention because of capsular contracture, hematoma/seroma, infection, asymmetry with displacement, rippling of skin, pain, and rupture. Among them, the most prominent complication is capsular contracture, which accounts for 16.2%-55% of all cases of revision surgery.4,5,6 Figure 40.1 Structure of PDMS, the base material for silicone implants.

Original languageEnglish
Title of host publicationHandbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition
PublisherPan Stanford Publishing Pte. Ltd.
Pages1211-1242
Number of pages32
ISBN (Electronic)9789814745130
ISBN (Print)9789814745123
DOIs
StatePublished - 1 Jan 2017

Fingerprint

Silicones
Coatings
Breast
Contracture
Plastic Surgery
Surgery
Silicone Gels
Tissue
Breast Implants
Seroma
Gels
Beauty
Mammaplasty
Mastectomy
Infection
Biocompatibility
Cosmetics
Hematoma
Crosslinking
Polydimethylsiloxane

Cite this

Ham, J., Kang, S., Park, J. U., & Lee, Y. (2017). Biocompatible surface coatings for silicone-based implants. In Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition (pp. 1211-1242). Pan Stanford Publishing Pte. Ltd.. https://doi.org/10.1201/9781315364698
Ham, Jiyeon ; Kang, Sunah ; Park, Ji Ung ; Lee, Yan. / Biocompatible surface coatings for silicone-based implants. Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition. Pan Stanford Publishing Pte. Ltd., 2017. pp. 1211-1242
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Ham, J, Kang, S, Park, JU & Lee, Y 2017, Biocompatible surface coatings for silicone-based implants. in Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition. Pan Stanford Publishing Pte. Ltd., pp. 1211-1242. https://doi.org/10.1201/9781315364698

Biocompatible surface coatings for silicone-based implants. / Ham, Jiyeon; Kang, Sunah; Park, Ji Ung; Lee, Yan.

Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition. Pan Stanford Publishing Pte. Ltd., 2017. p. 1211-1242.

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Ham J, Kang S, Park JU, Lee Y. Biocompatible surface coatings for silicone-based implants. In Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine, 2nd Edition. Pan Stanford Publishing Pte. Ltd. 2017. p. 1211-1242 https://doi.org/10.1201/9781315364698