Baseline characteristics of participants enrolled in the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD)

Peong Gang Park, Hee Gyung Kang, Eujin Park, Yo Han Ahn, Hyun Jin Choi, Kyoung Hee Han, Seong Heon Kim, Heeyeon Cho, Keum Hwa Lee, Jae Il Shin, Min Hyun Cho, Joo Hoon Lee, Young Seo Park, Jayoun Kim, Il Soo Ha

Research output: Contribution to journalArticlepeer-review

Abstract

Background: We developed the KoreaN cohort study for Outcomes in patients With Pediatric Chronic Kidney Disease (KNOW-Ped CKD) as a subcohort of KNOW-CKD to investigate the different characteristics of pediatric CKD between countries and races. Methods: Children aged younger than 18 years with stage 1 ~ 5 CKD were recruited at seven major pediatric nephrology centers in Korea. Blood and urine samples, as well as demographic and clinical data, were collected. From 2011 to 2016, 458 children were enrolled, and the baseline profiles of 437 children were analyzed. Results: The median age of the cohort was 10.9 years old, and 68.0% were males. The median estimated glomerular filtration rate was 53.1 mL/min/1.73 m2. The most common etiology of CKD was congenital anomalies of the kidney and urinary tract (42.6%), followed by glomerulopathies (25.6%). Conclusion: We report a cross-sectional analysis of the overall baseline characteristics such as age, CKD stage, and underlying kidney disease of the KNOW-Ped CKD. The cohort will be longitudinally followed for ten years. Graphical abstract: “A higher resolution version of the Graphical abstract is available as Supplementary information.” [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)3177-3187
Number of pages11
JournalPediatric Nephrology
Volume37
Issue number12
DOIs
StatePublished - Dec 2022

Keywords

  • Baseline characteristics
  • Chronic kidney disease
  • Cohort
  • KNOW-Ped CKD

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