B cell lineage contributions to antiviral host responses

N. Baumgarth, Youn Soo Choi, K. Rothaeusler, Y. Yang, L. A. Herzenberg

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

27 Citations (Scopus)

Abstract

B cell responses are a major immune protective mechanism induced against a large variety of pathogens. Technical advances over the last decade, particularly in the isolation and characterization of B cell subsets by multicolor flow cytometry, have demonstrated the multifaceted nature of pathogen-induced B cell responses. In addition to participation by the major follicular B cell population, three B cell subsets are now recognized as key contributors to pathogen-induced host defenses: marginal zone (MZ) B cells, B-1a and B-1b cells. Each of these subsets seems to require unique activation signals and to react with distinct response patterns. Here we provide a brief review of the main developmental and functional features of these B cell subsets. Furthermore, we outline our current understanding of how each subset contributes to the humoral response to influenza virus infection and what regulates their differential responses. Understanding of the multilayered nature of the humoral responses to infectious agents and the complex innate immune signals that shape pathogen-specific humoral responses are likely at the heart of enhancing our ability to induce appropriate and long-lasting humoral responses for prophylaxis and therapy.

Original languageEnglish
Title of host publicationSpecialization and Complementation of Humoral Immune Responses to Infection
EditorsTim Manser
Pages41-61
Number of pages21
DOIs
StatePublished - 1 Dec 2008

Publication series

NameCurrent Topics in Microbiology and Immunology
Volume319
ISSN (Print)0070-217X

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Cell Lineage
B-Lymphocyte Subsets
Antiviral Agents
B-Lymphocytes
Virus Diseases
Antigen-Antibody Complex
Orthomyxoviridae
Flow Cytometry
Population
Therapeutics

Cite this

Baumgarth, N., Choi, Y. S., Rothaeusler, K., Yang, Y., & Herzenberg, L. A. (2008). B cell lineage contributions to antiviral host responses. In T. Manser (Ed.), Specialization and Complementation of Humoral Immune Responses to Infection (pp. 41-61). (Current Topics in Microbiology and Immunology; Vol. 319). https://doi.org/10.1007/978-3-540-73900-5_3
Baumgarth, N. ; Choi, Youn Soo ; Rothaeusler, K. ; Yang, Y. ; Herzenberg, L. A. / B cell lineage contributions to antiviral host responses. Specialization and Complementation of Humoral Immune Responses to Infection. editor / Tim Manser. 2008. pp. 41-61 (Current Topics in Microbiology and Immunology).
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Baumgarth, N, Choi, YS, Rothaeusler, K, Yang, Y & Herzenberg, LA 2008, B cell lineage contributions to antiviral host responses. in T Manser (ed.), Specialization and Complementation of Humoral Immune Responses to Infection. Current Topics in Microbiology and Immunology, vol. 319, pp. 41-61. https://doi.org/10.1007/978-3-540-73900-5_3

B cell lineage contributions to antiviral host responses. / Baumgarth, N.; Choi, Youn Soo; Rothaeusler, K.; Yang, Y.; Herzenberg, L. A.

Specialization and Complementation of Humoral Immune Responses to Infection. ed. / Tim Manser. 2008. p. 41-61 (Current Topics in Microbiology and Immunology; Vol. 319).

Research output: Chapter in Book/Report/Conference proceedingChapterResearchpeer-review

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Baumgarth N, Choi YS, Rothaeusler K, Yang Y, Herzenberg LA. B cell lineage contributions to antiviral host responses. In Manser T, editor, Specialization and Complementation of Humoral Immune Responses to Infection. 2008. p. 41-61. (Current Topics in Microbiology and Immunology). https://doi.org/10.1007/978-3-540-73900-5_3