Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation

Jae-Il Lee, Hwa Young Son, Myung Cheol Kim

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

This study examined the effects of ascorbic acid on the attenuation of an ischemia-reperfusion (I/R) injury after a canine renal transplantation. Eight beagle dogs were subjected to a renal auto-transplantation followed by the administration of ascorbic acid (treatment group) and the same amount of vehicle (physiological saline, control group). Blood samples were collected from these dogs to perform the kidney function tests and the invasive blood pressure was measured in the renal artery at pre- and post- anastomosis. The antioxidant enzymes of level 72 h after the transplant were measured. The kidneys were taken for a histopathology evaluation at day 21. The kidney function tests showed a significant difference between the control and treatment group. The invasive blood pressure in the renal artery was similar in the groups. The activity of the antioxidant enzymes in the blood plasma was significant lower in the control group than in the treatment group. The histopathology findings revealed the treatment group to have less damage than the control group. The results of this study suggest that ascorbic acid alone might play a role in attenuating I/R injury and assist in the recovery of the renal function in a renal transplantation model.

Original languageEnglish
Pages (from-to)375-379
Number of pages5
JournalJournal of Veterinary Science
Volume7
Issue number4
DOIs
StatePublished - 1 Jan 2006

Fingerprint

kidney transplant
ischemia
Reperfusion Injury
Kidney Transplantation
Ascorbic Acid
Canidae
renal function
Kidney Function Tests
ascorbic acid
kidneys
Control Groups
dogs
Renal Artery
histopathology
arteries
blood pressure
Antioxidants
Dogs
autografting
Blood Pressure

Keywords

  • Antioxidant
  • Ascorbic acid
  • Canine
  • Renal transplantation

Cite this

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Attenuation of ischemia-reperfusion injury by ascorbic acid in the canine renal transplantation. / Lee, Jae-Il; Son, Hwa Young; Kim, Myung Cheol.

In: Journal of Veterinary Science, Vol. 7, No. 4, 01.01.2006, p. 375-379.

Research output: Contribution to journalArticleResearchpeer-review

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