4 Citations (Scopus)

Abstract

Background: FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients. Methods: A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 polymorphisms (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, and rs2232365 G/A) were determined by PCR and sequencing. Results: Genotype frequencies (GF) of rs5902434 ATT/ATT and rs2232365 GG were significantly decreased in female RRP patients than controls (0.0% vs 23.0%, p = 0.039, OR = 9.4 for both). Conclusions: We showed that Foxp3 polymorphism of rs5902434 and rs2232365 could be an important protective factor in the susceptibility of severe RRP in female Koreans. Further studies on larger number of patients and other ethnic groups are needed to clarify the association.

Original languageEnglish
Article number21
JournalJournal of Otolaryngology - Head and Neck Surgery
Volume46
Issue number1
DOIs
StatePublished - 15 Mar 2017

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Genes
Immune Tolerance
Virus Diseases
Regulatory T-Lymphocytes
Ethnic Groups
Autoimmune Diseases
Genotype
Polymerase Chain Reaction
Recurrent respiratory papillomatosis
Protective Factors

Keywords

  • Disease susceptibility
  • Foxp3
  • Human papilloma virus
  • Recurrent respiratory papillomatosis
  • Single nucleotide polymorphism

Cite this

@article{484fff1a0f26404bbee2ffb72697b55c,
title = "Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients",
abstract = "Background: FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients. Methods: A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 polymorphisms (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, and rs2232365 G/A) were determined by PCR and sequencing. Results: Genotype frequencies (GF) of rs5902434 ATT/ATT and rs2232365 GG were significantly decreased in female RRP patients than controls (0.0{\%} vs 23.0{\%}, p = 0.039, OR = 9.4 for both). Conclusions: We showed that Foxp3 polymorphism of rs5902434 and rs2232365 could be an important protective factor in the susceptibility of severe RRP in female Koreans. Further studies on larger number of patients and other ethnic groups are needed to clarify the association.",
keywords = "Disease susceptibility, Foxp3, Human papilloma virus, Recurrent respiratory papillomatosis, Single nucleotide polymorphism",
author = "Tack-Kyun Kwon and Eun-Jae Chung and Nuri Lee and Roh, {Eun Youn} and Song, {Eun Young}",
year = "2017",
month = "3",
day = "15",
doi = "10.1186/s40463-017-0197-z",
language = "English",
volume = "46",
journal = "Journal of Otolaryngology - Head and Neck Surgery",
issn = "1916-0216",
publisher = "Decker Publishing",
number = "1",

}

TY - JOUR

T1 - Associations of FoxP3 gene polymorphisms with severe recurrent respiratory papillomatosis in Korean patients

AU - Kwon, Tack-Kyun

AU - Chung, Eun-Jae

AU - Lee, Nuri

AU - Roh, Eun Youn

AU - Song, Eun Young

PY - 2017/3/15

Y1 - 2017/3/15

N2 - Background: FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients. Methods: A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 polymorphisms (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, and rs2232365 G/A) were determined by PCR and sequencing. Results: Genotype frequencies (GF) of rs5902434 ATT/ATT and rs2232365 GG were significantly decreased in female RRP patients than controls (0.0% vs 23.0%, p = 0.039, OR = 9.4 for both). Conclusions: We showed that Foxp3 polymorphism of rs5902434 and rs2232365 could be an important protective factor in the susceptibility of severe RRP in female Koreans. Further studies on larger number of patients and other ethnic groups are needed to clarify the association.

AB - Background: FoxP3 is the most dependable marker for regulatory T cells which play a major role in immune tolerance. Foxp3 gene polymorphisms were associated with various autoimmune diseases and clearance of viral infections. We studied the association of Foxp3 polymorphisms in severe RRP patients. Methods: A total of 30 Korean severe RRP patients and 195 healthy controls were enrolled. Foxp3 polymorphisms (rs5902434 del/ATT, rs3761548 C/A, rs3761549 C/T, and rs2232365 G/A) were determined by PCR and sequencing. Results: Genotype frequencies (GF) of rs5902434 ATT/ATT and rs2232365 GG were significantly decreased in female RRP patients than controls (0.0% vs 23.0%, p = 0.039, OR = 9.4 for both). Conclusions: We showed that Foxp3 polymorphism of rs5902434 and rs2232365 could be an important protective factor in the susceptibility of severe RRP in female Koreans. Further studies on larger number of patients and other ethnic groups are needed to clarify the association.

KW - Disease susceptibility

KW - Foxp3

KW - Human papilloma virus

KW - Recurrent respiratory papillomatosis

KW - Single nucleotide polymorphism

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U2 - 10.1186/s40463-017-0197-z

DO - 10.1186/s40463-017-0197-z

M3 - Short survey

VL - 46

JO - Journal of Otolaryngology - Head and Neck Surgery

JF - Journal of Otolaryngology - Head and Neck Surgery

SN - 1916-0216

IS - 1

M1 - 21

ER -