Associations between thyroid hormone levels and regional fat accumulation in euthyroid men

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Abstract

Objective: Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. Methods: A total of 100 euthyroid men (free triiodothyronine (fT3), 4.77±1.21 pg/ml; free thyroxine (fT4), 1.38±0.21 ng/dl; and TSH, 2.09±0.91 μIU/ml) were enrolled in this cross-sectional study.We measured accumulated regional fat using 64-slice multi-detector computed tomography. Multiple linear regression analysis was used to determine whether accumulated fat in each region was associated with clinical parameters after adjusting for age. Results: FT3 was inversely correlated with BMI (r=-0.232, P=0.029) and LDL cholesterol level (r=-0.277, P=0.019). FT4 was inversely correlated with waist circumference (r=-0.350, P=0.008) and BMI (r=-0.355, P<0.001). In multiple linear regression analysis, fT3 and fT4 levels were significantly associated with pericardial fat volume (fT3: B=-0.079, 95% CI -0.142 to -0.017, P=0.013; fT4: B=-0.411, 95% CI -0.780 to -0.042, P=0.030) in euthyroid men, independent of age. FT3 level was inversely associated with intramuscular fat area (B=-0.059, 95% CI -0.106 to -0.011, P=0.016) and hepatic fat quantity (B=-0.237, 95% CI -0.441 to -0.033, P=0.024) in euthyroid men, independent of age. Conclusions: In euthyroid men, low levels of fT3 and fT4 were significantly associated with increased pericardial fat volume and BMI.

Original languageEnglish
Pages (from-to)805-810
Number of pages6
JournalEuropean Journal of Endocrinology
Volume168
Issue number6
DOIs
StatePublished - 1 Jun 2013

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Thyroid Hormones
Fats
Linear Models
Regression Analysis
Adiposity
Waist Circumference
Triiodothyronine
Thyroxine
LDL Cholesterol
Thyroid Gland
Cross-Sectional Studies
Tomography
Liver

Cite this

@article{37f7423fd312479e843fa6c7496cfff0,
title = "Associations between thyroid hormone levels and regional fat accumulation in euthyroid men",
abstract = "Objective: Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. Methods: A total of 100 euthyroid men (free triiodothyronine (fT3), 4.77±1.21 pg/ml; free thyroxine (fT4), 1.38±0.21 ng/dl; and TSH, 2.09±0.91 μIU/ml) were enrolled in this cross-sectional study.We measured accumulated regional fat using 64-slice multi-detector computed tomography. Multiple linear regression analysis was used to determine whether accumulated fat in each region was associated with clinical parameters after adjusting for age. Results: FT3 was inversely correlated with BMI (r=-0.232, P=0.029) and LDL cholesterol level (r=-0.277, P=0.019). FT4 was inversely correlated with waist circumference (r=-0.350, P=0.008) and BMI (r=-0.355, P<0.001). In multiple linear regression analysis, fT3 and fT4 levels were significantly associated with pericardial fat volume (fT3: B=-0.079, 95{\%} CI -0.142 to -0.017, P=0.013; fT4: B=-0.411, 95{\%} CI -0.780 to -0.042, P=0.030) in euthyroid men, independent of age. FT3 level was inversely associated with intramuscular fat area (B=-0.059, 95{\%} CI -0.106 to -0.011, P=0.016) and hepatic fat quantity (B=-0.237, 95{\%} CI -0.441 to -0.033, P=0.024) in euthyroid men, independent of age. Conclusions: In euthyroid men, low levels of fT3 and fT4 were significantly associated with increased pericardial fat volume and BMI.",
author = "Moon, {Min Kyong} and Hong, {Eun Shil} and Lim, {Jung Ah} and Cho, {Sun Wook} and Lim Soo and Choi, {Sung Hee} and Yi, {Ka Hee} and Park, {Do Joon} and Park, {Young Joo} and Jang, {Hak Chul}",
year = "2013",
month = "6",
day = "1",
doi = "10.1530/EJE-12-0991",
language = "English",
volume = "168",
pages = "805--810",
journal = "European journal of endocrinology",
issn = "0804-4643",
publisher = "BioScientifica Ltd.",
number = "6",

}

TY - JOUR

T1 - Associations between thyroid hormone levels and regional fat accumulation in euthyroid men

AU - Moon, Min Kyong

AU - Hong, Eun Shil

AU - Lim, Jung Ah

AU - Cho, Sun Wook

AU - Soo, Lim

AU - Choi, Sung Hee

AU - Yi, Ka Hee

AU - Park, Do Joon

AU - Park, Young Joo

AU - Jang, Hak Chul

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Objective: Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. Methods: A total of 100 euthyroid men (free triiodothyronine (fT3), 4.77±1.21 pg/ml; free thyroxine (fT4), 1.38±0.21 ng/dl; and TSH, 2.09±0.91 μIU/ml) were enrolled in this cross-sectional study.We measured accumulated regional fat using 64-slice multi-detector computed tomography. Multiple linear regression analysis was used to determine whether accumulated fat in each region was associated with clinical parameters after adjusting for age. Results: FT3 was inversely correlated with BMI (r=-0.232, P=0.029) and LDL cholesterol level (r=-0.277, P=0.019). FT4 was inversely correlated with waist circumference (r=-0.350, P=0.008) and BMI (r=-0.355, P<0.001). In multiple linear regression analysis, fT3 and fT4 levels were significantly associated with pericardial fat volume (fT3: B=-0.079, 95% CI -0.142 to -0.017, P=0.013; fT4: B=-0.411, 95% CI -0.780 to -0.042, P=0.030) in euthyroid men, independent of age. FT3 level was inversely associated with intramuscular fat area (B=-0.059, 95% CI -0.106 to -0.011, P=0.016) and hepatic fat quantity (B=-0.237, 95% CI -0.441 to -0.033, P=0.024) in euthyroid men, independent of age. Conclusions: In euthyroid men, low levels of fT3 and fT4 were significantly associated with increased pericardial fat volume and BMI.

AB - Objective: Body adiposity, especially ectopic fat accumulation, has a range of metabolic and cardiovascular effects. This study aimed to investigate whether thyroid function is associated with various regional fat quantities in euthyroid subjects. Methods: A total of 100 euthyroid men (free triiodothyronine (fT3), 4.77±1.21 pg/ml; free thyroxine (fT4), 1.38±0.21 ng/dl; and TSH, 2.09±0.91 μIU/ml) were enrolled in this cross-sectional study.We measured accumulated regional fat using 64-slice multi-detector computed tomography. Multiple linear regression analysis was used to determine whether accumulated fat in each region was associated with clinical parameters after adjusting for age. Results: FT3 was inversely correlated with BMI (r=-0.232, P=0.029) and LDL cholesterol level (r=-0.277, P=0.019). FT4 was inversely correlated with waist circumference (r=-0.350, P=0.008) and BMI (r=-0.355, P<0.001). In multiple linear regression analysis, fT3 and fT4 levels were significantly associated with pericardial fat volume (fT3: B=-0.079, 95% CI -0.142 to -0.017, P=0.013; fT4: B=-0.411, 95% CI -0.780 to -0.042, P=0.030) in euthyroid men, independent of age. FT3 level was inversely associated with intramuscular fat area (B=-0.059, 95% CI -0.106 to -0.011, P=0.016) and hepatic fat quantity (B=-0.237, 95% CI -0.441 to -0.033, P=0.024) in euthyroid men, independent of age. Conclusions: In euthyroid men, low levels of fT3 and fT4 were significantly associated with increased pericardial fat volume and BMI.

UR - http://www.scopus.com/inward/record.url?scp=84878685207&partnerID=8YFLogxK

U2 - 10.1530/EJE-12-0991

DO - 10.1530/EJE-12-0991

M3 - Article

C2 - 23513229

AN - SCOPUS:84878685207

VL - 168

SP - 805

EP - 810

JO - European journal of endocrinology

JF - European journal of endocrinology

SN - 0804-4643

IS - 6

ER -