Association of angiotensin-II levels with albuminuria in subjects with normal glucose metabolism, prediabetes, and type 2 diabetes mellitus

Se Hee Min, Sung Hye Kong, Jie Eun Lee, Dong Hwa Lee, Tae Jung Oh, Kyoung Min Kim, Kyong Soo Park, Hak Chul Jang, Soo Lim

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Abstract

Objectives The relationship between the renin–angiotensin system (RAS) and diabetes has been studied for many years. However, studies that assessed RAS components comprehensively were limited. We hypothesized that serum RAS components, especially the effector peptide angiotensin-II, might be closely associated with glucose metabolism status and diabetic complications. Methods We investigated the association of individual RAS component with albuminuria in 407 subjects with normal glucose metabolism (NGM), prediabetes, or type 2 diabetes mellitus (T2DM). Anthropometric and biochemical parameters, including glucose homeostasis, albuminuria, and RAS-related parameters such as plasma renin activity (PRA), aldosterone, angiotensin-converting enzyme (ACE), and angiotensin-II levels, were measured. Results The mean ± standard deviation (SD) age and body mass index were 57.1 ± 11.1 years and 24.7 ± 3.3 kg/m2, respectively. There were 54 subjects with NGM, 102 with prediabetes, and 251 with T2DM. The mean ± SD angiotensin-II levels in these groups were 9.32 ± 6.89, 12.89 ± 10.39, and 17.00 ± 15.28 pg/mL, and the respective urinary albumin-to-creatinine ratios (ACRs) were 8.1 ± 5.3, 13.3 ± 17.3, and 30.7 ± 51.9 mg/g, which were significantly different among the groups. The serum angiotensin-II levels were correlated with levels of PRA, insulin resistance, C-reactive protein, and urinary ACR. Among RAS-related parameters, only the angiotensin-II level was significantly associated with urinary ACR after adjusting for relevant risk factors. Conclusions Angiotensin-II may play an important role in the development of albuminuria, particularly in subjects with impaired glucose metabolism.

Original languageEnglish
Pages (from-to)1499-1505
Number of pages7
JournalJournal of Diabetes and its Complications
Volume31
Issue number10
DOIs
StatePublished - Oct 2017

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Prediabetic State
Albuminuria
Angiotensin II
Type 2 Diabetes Mellitus
Glucose
Albumins
Creatinine
Renin
Peptidyl-Dipeptidase A
Diabetes Complications
Aldosterone
Serum
C-Reactive Protein
Insulin Resistance
Body Mass Index
Homeostasis
Peptides

Keywords

  • Angiotensin-II
  • Microvascular complications
  • RAS
  • albuminuria
  • type 2 diabetes

Cite this

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title = "Association of angiotensin-II levels with albuminuria in subjects with normal glucose metabolism, prediabetes, and type 2 diabetes mellitus",
abstract = "Objectives The relationship between the renin–angiotensin system (RAS) and diabetes has been studied for many years. However, studies that assessed RAS components comprehensively were limited. We hypothesized that serum RAS components, especially the effector peptide angiotensin-II, might be closely associated with glucose metabolism status and diabetic complications. Methods We investigated the association of individual RAS component with albuminuria in 407 subjects with normal glucose metabolism (NGM), prediabetes, or type 2 diabetes mellitus (T2DM). Anthropometric and biochemical parameters, including glucose homeostasis, albuminuria, and RAS-related parameters such as plasma renin activity (PRA), aldosterone, angiotensin-converting enzyme (ACE), and angiotensin-II levels, were measured. Results The mean ± standard deviation (SD) age and body mass index were 57.1 ± 11.1 years and 24.7 ± 3.3 kg/m2, respectively. There were 54 subjects with NGM, 102 with prediabetes, and 251 with T2DM. The mean ± SD angiotensin-II levels in these groups were 9.32 ± 6.89, 12.89 ± 10.39, and 17.00 ± 15.28 pg/mL, and the respective urinary albumin-to-creatinine ratios (ACRs) were 8.1 ± 5.3, 13.3 ± 17.3, and 30.7 ± 51.9 mg/g, which were significantly different among the groups. The serum angiotensin-II levels were correlated with levels of PRA, insulin resistance, C-reactive protein, and urinary ACR. Among RAS-related parameters, only the angiotensin-II level was significantly associated with urinary ACR after adjusting for relevant risk factors. Conclusions Angiotensin-II may play an important role in the development of albuminuria, particularly in subjects with impaired glucose metabolism.",
keywords = "Angiotensin-II, Microvascular complications, RAS, albuminuria, type 2 diabetes",
author = "Min, {Se Hee} and Kong, {Sung Hye} and Lee, {Jie Eun} and Lee, {Dong Hwa} and Oh, {Tae Jung} and Kim, {Kyoung Min} and Park, {Kyong Soo} and Jang, {Hak Chul} and Soo Lim",
year = "2017",
month = "10",
doi = "10.1016/j.jdiacomp.2017.07.002",
language = "English",
volume = "31",
pages = "1499--1505",
journal = "Journal of Diabetes and its Complications",
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}

TY - JOUR

T1 - Association of angiotensin-II levels with albuminuria in subjects with normal glucose metabolism, prediabetes, and type 2 diabetes mellitus

AU - Min, Se Hee

AU - Kong, Sung Hye

AU - Lee, Jie Eun

AU - Lee, Dong Hwa

AU - Oh, Tae Jung

AU - Kim, Kyoung Min

AU - Park, Kyong Soo

AU - Jang, Hak Chul

AU - Lim, Soo

PY - 2017/10

Y1 - 2017/10

N2 - Objectives The relationship between the renin–angiotensin system (RAS) and diabetes has been studied for many years. However, studies that assessed RAS components comprehensively were limited. We hypothesized that serum RAS components, especially the effector peptide angiotensin-II, might be closely associated with glucose metabolism status and diabetic complications. Methods We investigated the association of individual RAS component with albuminuria in 407 subjects with normal glucose metabolism (NGM), prediabetes, or type 2 diabetes mellitus (T2DM). Anthropometric and biochemical parameters, including glucose homeostasis, albuminuria, and RAS-related parameters such as plasma renin activity (PRA), aldosterone, angiotensin-converting enzyme (ACE), and angiotensin-II levels, were measured. Results The mean ± standard deviation (SD) age and body mass index were 57.1 ± 11.1 years and 24.7 ± 3.3 kg/m2, respectively. There were 54 subjects with NGM, 102 with prediabetes, and 251 with T2DM. The mean ± SD angiotensin-II levels in these groups were 9.32 ± 6.89, 12.89 ± 10.39, and 17.00 ± 15.28 pg/mL, and the respective urinary albumin-to-creatinine ratios (ACRs) were 8.1 ± 5.3, 13.3 ± 17.3, and 30.7 ± 51.9 mg/g, which were significantly different among the groups. The serum angiotensin-II levels were correlated with levels of PRA, insulin resistance, C-reactive protein, and urinary ACR. Among RAS-related parameters, only the angiotensin-II level was significantly associated with urinary ACR after adjusting for relevant risk factors. Conclusions Angiotensin-II may play an important role in the development of albuminuria, particularly in subjects with impaired glucose metabolism.

AB - Objectives The relationship between the renin–angiotensin system (RAS) and diabetes has been studied for many years. However, studies that assessed RAS components comprehensively were limited. We hypothesized that serum RAS components, especially the effector peptide angiotensin-II, might be closely associated with glucose metabolism status and diabetic complications. Methods We investigated the association of individual RAS component with albuminuria in 407 subjects with normal glucose metabolism (NGM), prediabetes, or type 2 diabetes mellitus (T2DM). Anthropometric and biochemical parameters, including glucose homeostasis, albuminuria, and RAS-related parameters such as plasma renin activity (PRA), aldosterone, angiotensin-converting enzyme (ACE), and angiotensin-II levels, were measured. Results The mean ± standard deviation (SD) age and body mass index were 57.1 ± 11.1 years and 24.7 ± 3.3 kg/m2, respectively. There were 54 subjects with NGM, 102 with prediabetes, and 251 with T2DM. The mean ± SD angiotensin-II levels in these groups were 9.32 ± 6.89, 12.89 ± 10.39, and 17.00 ± 15.28 pg/mL, and the respective urinary albumin-to-creatinine ratios (ACRs) were 8.1 ± 5.3, 13.3 ± 17.3, and 30.7 ± 51.9 mg/g, which were significantly different among the groups. The serum angiotensin-II levels were correlated with levels of PRA, insulin resistance, C-reactive protein, and urinary ACR. Among RAS-related parameters, only the angiotensin-II level was significantly associated with urinary ACR after adjusting for relevant risk factors. Conclusions Angiotensin-II may play an important role in the development of albuminuria, particularly in subjects with impaired glucose metabolism.

KW - Angiotensin-II

KW - Microvascular complications

KW - RAS

KW - albuminuria

KW - type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85026864397&partnerID=8YFLogxK

U2 - 10.1016/j.jdiacomp.2017.07.002

DO - 10.1016/j.jdiacomp.2017.07.002

M3 - Article

C2 - 28797632

AN - SCOPUS:85026864397

VL - 31

SP - 1499

EP - 1505

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

IS - 10

ER -