Association of air pollutants with incident chronic kidney disease in a nationally representative cohort of Korean adults

Seo Yun Hwang, Seogsong Jeong, Seulggie Choi, Dong Hyun Kim, Seong Rae Kim, Gyeongsil Lee, Joung Sik Son, Sang Min Park

Research output: Contribution to journalArticlepeer-review

Abstract

(1) Background: There is limited information regarding association between long-term exposure to air pollutants and risk of chronic kidney disease (CKD) (2). Methods: This study ac-quired data of 164,093 adults aged at least 40 years who were residing in 7 metropolitan cities between 2002 and 2005 from the Korean National Health Insurance Service National Sample Cohort database. CKD risk was evaluated using the multivariate Cox hazards proportional regression. All participants were followed up with until CKD, death, or 31 December 2013, whichever occurred earliest. (3) Results: Among 1,259,461 person-years of follow-up investigation, CKD cases occurred in 1,494 participants. Air pollutant exposures including PM10, SO2, NO2, CO, and O3 showed no significant association with incident CKD after adjustments for age, sex, household income, area of residence, and the Charlson comorbidity index. The results were consistent in the sensitivity analyses including first and last year annual exposure analyses as well as latent periods-washed-out analyses. (4) Conclusions: Long-term exposure to air pollution is not likely to increase the risk of CKD.

Original languageEnglish
Article number3775
JournalInternational journal of environmental research and public health
Volume18
Issue number7
DOIs
StatePublished - 1 Apr 2021

Keywords

  • Air pollution
  • Cohort study
  • Ozone
  • Particulate matter
  • Renal failure

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