Association of Age-Related Macular Degeneration on Alzheimer or Parkinson Disease: A Retrospective Cohort Study

Seulggie Choi, Wan Jin Jahng, Sang Min Park, Donghyun Jee

Research output: Contribution to journalArticle

Abstract

Purpose: To determine the association of age-related macular degeneration (AMD) with Alzheimer disease (AD) and Parkinson disease (PD). Design: Retrospective cohort study. Methods: The study population consisted of 308,340 participants aged 50 years or older from the Korean National Health Insurance Service–Health Screening Cohort. After exclusion of participants with AMD during 2002, participants were detected for AMD during 2003-2005. Starting from January 1, 2006, all participants were followed up for AD and PD until December 31, 2013. Multivariate Cox proportional hazards regression was used to calculate the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for AD and PD risk. Results: Compared to non-AMD participants, AMD patients had higher risk for AD (aHR 1.48, 95% CI 1.25-1.74) and PD (aHR 1.46, 95% CI 1.14-1.88). The risk-increasing association of AMD with AD (aHR 2.25, 95% CI 1.39-3.66) and PD (aHR 2.02, 95% CI 1.00-4.08) were preserved among participants who were never-smokers, did not consume alcohol, and exercised regularly. Finally, AMD was associated with higher risk of AD (aHR 1.96, 95% CI 1.46-2.65 for age <70 years and aHR 1.53, 95% CI 1.26-1.86 for age ≥70 years) and PD (aHR 1.90, 95% CI 1.29-2.80 for age <70 years and aHR 1.47, 95% CI 1.06-2.04 for age ≥70 years) according to subgroups divided by age. Conclusions: Compared to non-AMD participants, AMD patients had higher risk for AD and PD even among those with healthy lifestyle behaviors. Patients with AMD must be closely monitored for possible subsequent development of AD or PD.

Original languageEnglish
Pages (from-to)41-47
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume210
DOIs
StatePublished - Feb 2020

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Macular Degeneration
Parkinson Disease
Alzheimer Disease
Cohort Studies
Retrospective Studies
Confidence Intervals
National Health Programs
Alcohols

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@article{b2daeeafac504d7b8a6a28fd017bb564,
title = "Association of Age-Related Macular Degeneration on Alzheimer or Parkinson Disease: A Retrospective Cohort Study",
abstract = "Purpose: To determine the association of age-related macular degeneration (AMD) with Alzheimer disease (AD) and Parkinson disease (PD). Design: Retrospective cohort study. Methods: The study population consisted of 308,340 participants aged 50 years or older from the Korean National Health Insurance Service–Health Screening Cohort. After exclusion of participants with AMD during 2002, participants were detected for AMD during 2003-2005. Starting from January 1, 2006, all participants were followed up for AD and PD until December 31, 2013. Multivariate Cox proportional hazards regression was used to calculate the adjusted hazard ratios (aHRs) and 95{\%} confidence intervals (CIs) for AD and PD risk. Results: Compared to non-AMD participants, AMD patients had higher risk for AD (aHR 1.48, 95{\%} CI 1.25-1.74) and PD (aHR 1.46, 95{\%} CI 1.14-1.88). The risk-increasing association of AMD with AD (aHR 2.25, 95{\%} CI 1.39-3.66) and PD (aHR 2.02, 95{\%} CI 1.00-4.08) were preserved among participants who were never-smokers, did not consume alcohol, and exercised regularly. Finally, AMD was associated with higher risk of AD (aHR 1.96, 95{\%} CI 1.46-2.65 for age <70 years and aHR 1.53, 95{\%} CI 1.26-1.86 for age ≥70 years) and PD (aHR 1.90, 95{\%} CI 1.29-2.80 for age <70 years and aHR 1.47, 95{\%} CI 1.06-2.04 for age ≥70 years) according to subgroups divided by age. Conclusions: Compared to non-AMD participants, AMD patients had higher risk for AD and PD even among those with healthy lifestyle behaviors. Patients with AMD must be closely monitored for possible subsequent development of AD or PD.",
author = "Seulggie Choi and Jahng, {Wan Jin} and Park, {Sang Min} and Donghyun Jee",
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Association of Age-Related Macular Degeneration on Alzheimer or Parkinson Disease : A Retrospective Cohort Study. / Choi, Seulggie; Jahng, Wan Jin; Park, Sang Min; Jee, Donghyun.

In: American Journal of Ophthalmology, Vol. 210, 02.2020, p. 41-47.

Research output: Contribution to journalArticle

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T1 - Association of Age-Related Macular Degeneration on Alzheimer or Parkinson Disease

T2 - A Retrospective Cohort Study

AU - Choi, Seulggie

AU - Jahng, Wan Jin

AU - Park, Sang Min

AU - Jee, Donghyun

PY - 2020/2

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N2 - Purpose: To determine the association of age-related macular degeneration (AMD) with Alzheimer disease (AD) and Parkinson disease (PD). Design: Retrospective cohort study. Methods: The study population consisted of 308,340 participants aged 50 years or older from the Korean National Health Insurance Service–Health Screening Cohort. After exclusion of participants with AMD during 2002, participants were detected for AMD during 2003-2005. Starting from January 1, 2006, all participants were followed up for AD and PD until December 31, 2013. Multivariate Cox proportional hazards regression was used to calculate the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for AD and PD risk. Results: Compared to non-AMD participants, AMD patients had higher risk for AD (aHR 1.48, 95% CI 1.25-1.74) and PD (aHR 1.46, 95% CI 1.14-1.88). The risk-increasing association of AMD with AD (aHR 2.25, 95% CI 1.39-3.66) and PD (aHR 2.02, 95% CI 1.00-4.08) were preserved among participants who were never-smokers, did not consume alcohol, and exercised regularly. Finally, AMD was associated with higher risk of AD (aHR 1.96, 95% CI 1.46-2.65 for age <70 years and aHR 1.53, 95% CI 1.26-1.86 for age ≥70 years) and PD (aHR 1.90, 95% CI 1.29-2.80 for age <70 years and aHR 1.47, 95% CI 1.06-2.04 for age ≥70 years) according to subgroups divided by age. Conclusions: Compared to non-AMD participants, AMD patients had higher risk for AD and PD even among those with healthy lifestyle behaviors. Patients with AMD must be closely monitored for possible subsequent development of AD or PD.

AB - Purpose: To determine the association of age-related macular degeneration (AMD) with Alzheimer disease (AD) and Parkinson disease (PD). Design: Retrospective cohort study. Methods: The study population consisted of 308,340 participants aged 50 years or older from the Korean National Health Insurance Service–Health Screening Cohort. After exclusion of participants with AMD during 2002, participants were detected for AMD during 2003-2005. Starting from January 1, 2006, all participants were followed up for AD and PD until December 31, 2013. Multivariate Cox proportional hazards regression was used to calculate the adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for AD and PD risk. Results: Compared to non-AMD participants, AMD patients had higher risk for AD (aHR 1.48, 95% CI 1.25-1.74) and PD (aHR 1.46, 95% CI 1.14-1.88). The risk-increasing association of AMD with AD (aHR 2.25, 95% CI 1.39-3.66) and PD (aHR 2.02, 95% CI 1.00-4.08) were preserved among participants who were never-smokers, did not consume alcohol, and exercised regularly. Finally, AMD was associated with higher risk of AD (aHR 1.96, 95% CI 1.46-2.65 for age <70 years and aHR 1.53, 95% CI 1.26-1.86 for age ≥70 years) and PD (aHR 1.90, 95% CI 1.29-2.80 for age <70 years and aHR 1.47, 95% CI 1.06-2.04 for age ≥70 years) according to subgroups divided by age. Conclusions: Compared to non-AMD participants, AMD patients had higher risk for AD and PD even among those with healthy lifestyle behaviors. Patients with AMD must be closely monitored for possible subsequent development of AD or PD.

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