Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock

Jong Eun Park, Tae Gun Shin, Daun Jeong, Gun Tak Lee, Seung Mok Ryoo, Won Young Kim, You Hwan Jo, Gil Joon Suh, Sung Yeon Hwang

Research output: Contribution to journalArticlepeer-review


The prognostic value of low vitamin C levels has not been well investigated in patients with septic shock. We aimed to evaluate the association of vitamin C deficiency with mortality in patients with septic shock. We conducted a retrospective analysis of 165 patients with septic shock from a prospective multicenter trial and institutional sepsis registry between April 2018 and January 2020. The primary outcome was 28-day mortality. The patients were categorized into vitamin C deficiency and normal groups based on a vitamin C cutoff level of 11.4 mmol/L. Multivariable Cox regression analysis was performed to examine the association between vitamin C levels and 28-day mortality. A total of 165 patients was included for analysis and 77 (46.7%) had vitamin C deficiency. There was no significant difference in the 28-day mortality rate between the vitamin C deficiency group and the normal group (23.4% (n = 18/77) vs. 13.6% (n = 12/88), p = 0.083). Multivariable Cox proportional hazard analysis showed vitamin C deficiency to be associated with increased risk of 28-day mortality (adjusted hazard ratio, 2.65, 95% confidence interval (CI), 1.08–6.45; p = 0.032). Initial vitamin C deficiency was associated with a higher risk of 28-day mortality in patients with septic shock after adjusting for intravenous administration of vitamin C and thiamine, baseline characteristics, laboratory findings, and severity of illness.

Original languageEnglish
Article number2090
Issue number9
StatePublished - Sep 2022


  • ascorbic acid
  • mortality
  • sepsis
  • septic shock


Dive into the research topics of 'Association between Vitamin C Deficiency and Mortality in Patients with Septic Shock'. Together they form a unique fingerprint.

Cite this