Association between red blood cell storage duration and clinical outcome in patients undergoing off-pump coronary artery bypass surgery: A retrospective study

Jeong Jin Min, Jun Yeol Bae, Tae Kyong Kim, Deok Man Hong, Ho Young Hwang, Ki Bong Kim, Kyou Sup Han, Yunseok Jeon

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Prolonged storage of red blood cells (RBCs) leads to fundamental changes in both the RBCs and the storage media. We retrospectively evaluated the relationship between the RBC age and in-hospital and long-term postoperative outcomes in patients undergoing off-pump coronary artery bypass. Methods: The electronic medical records of 1, 072 OPCAB patients were reviewed and information on the transfused RBCs and clinical data were collected. The effects of RBCs age (mean age, oldest age of transfused RBCs, any RBCs older than 14 days) on various in-hospital postoperative complications and long-term major adverse cardiovascular and cerebral events over a mean follow-up of 31 months were investigated. Correlations between RBCs age and duration of intubation, intensive care unit, or hospital stay, and base excess at the first postoperative morning were also analyzed. Results: After adjusting for confounders, there was no relationship between the RBCs age and in-hospital and long-term clinical outcomes except for postoperative wound complications. A significant linear trend was observed between the oldest age quartiles of transfused RBCs and the postoperative wound complications (quartile 1 vs. 2, 3 and 4: OR, 8.92,12.01 and 13.79, respectively; P for trend = 0.009). The oldest transfused RBCs showed significant relationships with a first postoperative day negative base excess (P = 0.021), postoperative wound complications (P = 0.001), and length of hospital stay (P = 0.008). Conclusions: In patients undergoing off-pump coronary artery bypass, the oldest age of transfused RBCs were associated with a postoperative negative base excess, increased wound complications, and a longer hospital stay, but not with the other in-hospital or long-term outcomes.

Original languageEnglish
JournalBMC Anesthesiology
Volume14
Issue number1
DOIs
StatePublished - 1 Jan 2014

Fingerprint

Off-Pump Coronary Artery Bypass
Coronary Artery Bypass
Retrospective Studies
Erythrocytes
Length of Stay
Wounds and Injuries
Electronic Health Records
Intubation
Intensive Care Units

Keywords

  • Cardiac surgery
  • Old stored RBC
  • Postoperative outcome
  • RBC storage age
  • Wound complication

Cite this

@article{140d2d56c0ef47848052295be4d2b829,
title = "Association between red blood cell storage duration and clinical outcome in patients undergoing off-pump coronary artery bypass surgery: A retrospective study",
abstract = "Background: Prolonged storage of red blood cells (RBCs) leads to fundamental changes in both the RBCs and the storage media. We retrospectively evaluated the relationship between the RBC age and in-hospital and long-term postoperative outcomes in patients undergoing off-pump coronary artery bypass. Methods: The electronic medical records of 1, 072 OPCAB patients were reviewed and information on the transfused RBCs and clinical data were collected. The effects of RBCs age (mean age, oldest age of transfused RBCs, any RBCs older than 14 days) on various in-hospital postoperative complications and long-term major adverse cardiovascular and cerebral events over a mean follow-up of 31 months were investigated. Correlations between RBCs age and duration of intubation, intensive care unit, or hospital stay, and base excess at the first postoperative morning were also analyzed. Results: After adjusting for confounders, there was no relationship between the RBCs age and in-hospital and long-term clinical outcomes except for postoperative wound complications. A significant linear trend was observed between the oldest age quartiles of transfused RBCs and the postoperative wound complications (quartile 1 vs. 2, 3 and 4: OR, 8.92,12.01 and 13.79, respectively; P for trend = 0.009). The oldest transfused RBCs showed significant relationships with a first postoperative day negative base excess (P = 0.021), postoperative wound complications (P = 0.001), and length of hospital stay (P = 0.008). Conclusions: In patients undergoing off-pump coronary artery bypass, the oldest age of transfused RBCs were associated with a postoperative negative base excess, increased wound complications, and a longer hospital stay, but not with the other in-hospital or long-term outcomes.",
keywords = "Cardiac surgery, Old stored RBC, Postoperative outcome, RBC storage age, Wound complication",
author = "Min, {Jeong Jin} and Bae, {Jun Yeol} and Kim, {Tae Kyong} and Hong, {Deok Man} and Hwang, {Ho Young} and Kim, {Ki Bong} and Han, {Kyou Sup} and Yunseok Jeon",
year = "2014",
month = "1",
day = "1",
doi = "10.1186/1471-2253-14-95",
language = "English",
volume = "14",
journal = "BMC anesthesiology",
issn = "1471-2253",
publisher = "BioMed Central Ltd.",
number = "1",

}

TY - JOUR

T1 - Association between red blood cell storage duration and clinical outcome in patients undergoing off-pump coronary artery bypass surgery

T2 - A retrospective study

AU - Min, Jeong Jin

AU - Bae, Jun Yeol

AU - Kim, Tae Kyong

AU - Hong, Deok Man

AU - Hwang, Ho Young

AU - Kim, Ki Bong

AU - Han, Kyou Sup

AU - Jeon, Yunseok

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background: Prolonged storage of red blood cells (RBCs) leads to fundamental changes in both the RBCs and the storage media. We retrospectively evaluated the relationship between the RBC age and in-hospital and long-term postoperative outcomes in patients undergoing off-pump coronary artery bypass. Methods: The electronic medical records of 1, 072 OPCAB patients were reviewed and information on the transfused RBCs and clinical data were collected. The effects of RBCs age (mean age, oldest age of transfused RBCs, any RBCs older than 14 days) on various in-hospital postoperative complications and long-term major adverse cardiovascular and cerebral events over a mean follow-up of 31 months were investigated. Correlations between RBCs age and duration of intubation, intensive care unit, or hospital stay, and base excess at the first postoperative morning were also analyzed. Results: After adjusting for confounders, there was no relationship between the RBCs age and in-hospital and long-term clinical outcomes except for postoperative wound complications. A significant linear trend was observed between the oldest age quartiles of transfused RBCs and the postoperative wound complications (quartile 1 vs. 2, 3 and 4: OR, 8.92,12.01 and 13.79, respectively; P for trend = 0.009). The oldest transfused RBCs showed significant relationships with a first postoperative day negative base excess (P = 0.021), postoperative wound complications (P = 0.001), and length of hospital stay (P = 0.008). Conclusions: In patients undergoing off-pump coronary artery bypass, the oldest age of transfused RBCs were associated with a postoperative negative base excess, increased wound complications, and a longer hospital stay, but not with the other in-hospital or long-term outcomes.

AB - Background: Prolonged storage of red blood cells (RBCs) leads to fundamental changes in both the RBCs and the storage media. We retrospectively evaluated the relationship between the RBC age and in-hospital and long-term postoperative outcomes in patients undergoing off-pump coronary artery bypass. Methods: The electronic medical records of 1, 072 OPCAB patients were reviewed and information on the transfused RBCs and clinical data were collected. The effects of RBCs age (mean age, oldest age of transfused RBCs, any RBCs older than 14 days) on various in-hospital postoperative complications and long-term major adverse cardiovascular and cerebral events over a mean follow-up of 31 months were investigated. Correlations between RBCs age and duration of intubation, intensive care unit, or hospital stay, and base excess at the first postoperative morning were also analyzed. Results: After adjusting for confounders, there was no relationship between the RBCs age and in-hospital and long-term clinical outcomes except for postoperative wound complications. A significant linear trend was observed between the oldest age quartiles of transfused RBCs and the postoperative wound complications (quartile 1 vs. 2, 3 and 4: OR, 8.92,12.01 and 13.79, respectively; P for trend = 0.009). The oldest transfused RBCs showed significant relationships with a first postoperative day negative base excess (P = 0.021), postoperative wound complications (P = 0.001), and length of hospital stay (P = 0.008). Conclusions: In patients undergoing off-pump coronary artery bypass, the oldest age of transfused RBCs were associated with a postoperative negative base excess, increased wound complications, and a longer hospital stay, but not with the other in-hospital or long-term outcomes.

KW - Cardiac surgery

KW - Old stored RBC

KW - Postoperative outcome

KW - RBC storage age

KW - Wound complication

UR - http://www.scopus.com/inward/record.url?scp=84928583531&partnerID=8YFLogxK

U2 - 10.1186/1471-2253-14-95

DO - 10.1186/1471-2253-14-95

M3 - Article

C2 - 25352766

AN - SCOPUS:84928583531

VL - 14

JO - BMC anesthesiology

JF - BMC anesthesiology

SN - 1471-2253

IS - 1

ER -