Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer

Seung Soo Yoo, Mi Jeong Hong, Jang Hyuck Lee, Jin Eun Choi, Shin Yup Lee, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Yangki Seok, Eungbae Lee, Sukki Cho, Sanghoon Jheon, Jae Yong Park

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

A high-throughput mapping method of RNA–RNA interactions by crosslinking, ligation, and sequencing of hybrids (CLASH) can not only provide information about canonical but also non-canonical interactions. We evaluated the associations between variants in microRNA target sites using CLASH data and survival outcomes of 782 early-stage non-small cell lung cancer (NSCLC) patients who underwent curative surgical resection. Among the 100 variants studied, two variants showed significant association with survival outcomes. The POLR2A rs2071504 C > T variant was associated with poor overall and disease-free survival under a dominant model (hazard ratio [HR] 1.42, 95% confidence interval [CI] 1.08–1.88; P = 0.01 and HR 1.34, 95% CI 1.08–1.67; P = 0.01, respectively). Patients carrying the NR2F6 rs2288539 TT genotype showed significantly better overall survival than those with the NR2F6 rs2288539 CC or CT genotypes (HR 0.13, 95% CI 0.02–0.90; P = 0.04). These findings suggest that POLR2A rs2071504 C > T and NR2F6 rs2288539 C > T can influence prognosis in early-stage NSCLC patients.

Original languageEnglish
Pages (from-to)682-686
Number of pages5
JournalThoracic Cancer
Volume8
Issue number6
DOIs
StatePublished - Nov 2017

Keywords

  • miRNA target site
  • non-small cell lung cancer
  • polymorphism
  • survival outcome

Cite this

Yoo, S. S., Hong, M. J., Lee, J. H., Choi, J. E., Lee, S. Y., Lee, J., Cha, S. I., Kim, C. H., Seok, Y., Lee, E., Cho, S., Jheon, S., & Park, J. Y. (2017). Association between polymorphisms in microRNA target sites and survival in early-stage non-small cell lung cancer. Thoracic Cancer, 8(6), 682-686. https://doi.org/10.1111/1759-7714.12478