Association between FAT1 mutation and overall survival in patients with human papillomavirus-negative head and neck squamous cell carcinoma

Ki Tae Kim, Bo Sung Kim, Ju Han Kim

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (FAT1) and determine the prognostic significance of FAT1 mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) data portals and used as discovery and validation sets. FAT1 mutational status was determined in 234 and 37 patients with HPV-negative HNSCC, respectively, and overall survival analysis was performed. For comparison, HPV-positive patients were also analyzed for overall survival. Results Most of the identified nonsynonymous somatic FAT1 mutations were loss-of-function mutations. FAT1 mutation was significantly associated with better overall survival in HPV-negative patients from both the TCGA cohort (p =.026) and the ICGC cohort (p =.047), but not in HPV-positive patients. Conclusion FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative HNSCC.

Original languageEnglish
Pages (from-to)E2021-E2029
JournalHead and Neck
Volume38
DOIs
StatePublished - 1 Apr 2016

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Cadherins
Mutation
Survival
Genome
Atlases
Neoplasms
Survival Analysis
Carcinoma, squamous cell of head and neck

Keywords

  • FAT atypical cadherin 1
  • head and neck neoplasms
  • human papillomavirus
  • mutation
  • prognosis

Cite this

@article{9d9bfc5c67a54173b3a895b0955ba4c8,
title = "Association between FAT1 mutation and overall survival in patients with human papillomavirus-negative head and neck squamous cell carcinoma",
abstract = "Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (FAT1) and determine the prognostic significance of FAT1 mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) data portals and used as discovery and validation sets. FAT1 mutational status was determined in 234 and 37 patients with HPV-negative HNSCC, respectively, and overall survival analysis was performed. For comparison, HPV-positive patients were also analyzed for overall survival. Results Most of the identified nonsynonymous somatic FAT1 mutations were loss-of-function mutations. FAT1 mutation was significantly associated with better overall survival in HPV-negative patients from both the TCGA cohort (p =.026) and the ICGC cohort (p =.047), but not in HPV-positive patients. Conclusion FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative HNSCC.",
keywords = "FAT atypical cadherin 1, head and neck neoplasms, human papillomavirus, mutation, prognosis",
author = "Kim, {Ki Tae} and Kim, {Bo Sung} and Kim, {Ju Han}",
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doi = "10.1002/hed.24372",
language = "English",
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pages = "E2021--E2029",
journal = "Head & Neck",
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Association between FAT1 mutation and overall survival in patients with human papillomavirus-negative head and neck squamous cell carcinoma. / Kim, Ki Tae; Kim, Bo Sung; Kim, Ju Han.

In: Head and Neck, Vol. 38, 01.04.2016, p. E2021-E2029.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association between FAT1 mutation and overall survival in patients with human papillomavirus-negative head and neck squamous cell carcinoma

AU - Kim, Ki Tae

AU - Kim, Bo Sung

AU - Kim, Ju Han

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (FAT1) and determine the prognostic significance of FAT1 mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) data portals and used as discovery and validation sets. FAT1 mutational status was determined in 234 and 37 patients with HPV-negative HNSCC, respectively, and overall survival analysis was performed. For comparison, HPV-positive patients were also analyzed for overall survival. Results Most of the identified nonsynonymous somatic FAT1 mutations were loss-of-function mutations. FAT1 mutation was significantly associated with better overall survival in HPV-negative patients from both the TCGA cohort (p =.026) and the ICGC cohort (p =.047), but not in HPV-positive patients. Conclusion FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative HNSCC.

AB - Background The purpose of this study was to characterize the mutation profile of FAT atypical cadherin 1 (FAT1) and determine the prognostic significance of FAT1 mutation for overall survival in patients with human papillomavirus (HPV)-negative head and neck squamous cell carcinoma (HNSCC). Methods Data were downloaded from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) data portals and used as discovery and validation sets. FAT1 mutational status was determined in 234 and 37 patients with HPV-negative HNSCC, respectively, and overall survival analysis was performed. For comparison, HPV-positive patients were also analyzed for overall survival. Results Most of the identified nonsynonymous somatic FAT1 mutations were loss-of-function mutations. FAT1 mutation was significantly associated with better overall survival in HPV-negative patients from both the TCGA cohort (p =.026) and the ICGC cohort (p =.047), but not in HPV-positive patients. Conclusion FAT1 mutational status is a strong independent prognostic factor in patients with HPV-negative HNSCC.

KW - FAT atypical cadherin 1

KW - head and neck neoplasms

KW - human papillomavirus

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KW - prognosis

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