TY - JOUR
T1 - Association between endometriosis and polymorphisms in tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), TRAIL receptor and osteoprotegerin genes and their serum levels
AU - Kim, Hoon
AU - Ku, Seung Yup
AU - Suh, Chang Suk
AU - Kim, Seok Hyun
AU - Kim, Jong Hak
AU - Kim, Jung Gu
N1 - Funding Information:
This study was supported by a National Research Foundation of Korea Grant funded by the Korean Government (2010-0015704).
PY - 2012/7
Y1 - 2012/7
N2 - Purpose To evaluate the relationship between endometri-osis and polymorphisms in the genes encoding tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), TRAIL receptor (DR) and osteoprotegerin (OPG) and their serum levels in Korean women. Methods A case-control study was conducted with 138 women with endometriosis and 214 women without endo-metriosis in academic medical center. TRAIL c.49G>A, c.592A>G, c.615A>G, and c.662T>C; DR4 c.626G>C and c.1322A>G; DR5 c.95C>T, c.200C>T, and c.72T>G; OPG -245T>G, c.9C>G, c.788A>C, and c.9938G>T polymorphisms were investigated and circulating levels of TRAIL and OPG were measured. Results The TRAIL c.49G>A, c.615A>G, and c.662T>C; the DR4 c.626G>C; the DR5 c.72T>G; the OPG c.788A>C and c.9938G>T polymorphisms were not observed. The genotype distributions and allele frequencies of single or combined polymorphisms of TRAIL, DR4, DR5, and OPG measured in women with endometriosis were not diVerent from those in women without endometriosis, regardless of endometriosis stage. Serum TRAIL and OPG levels were signiWcantly lower in women with endometriosis than in women without endometriosis, but these levels did not show diVerences between early and advanced endometri-osis. Conclusions Endometriosis is associated with circulating TRAIL and OPG levels in Korean women but not with the TRAIL, DR, and OPG polymorphisms.
AB - Purpose To evaluate the relationship between endometri-osis and polymorphisms in the genes encoding tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), TRAIL receptor (DR) and osteoprotegerin (OPG) and their serum levels in Korean women. Methods A case-control study was conducted with 138 women with endometriosis and 214 women without endo-metriosis in academic medical center. TRAIL c.49G>A, c.592A>G, c.615A>G, and c.662T>C; DR4 c.626G>C and c.1322A>G; DR5 c.95C>T, c.200C>T, and c.72T>G; OPG -245T>G, c.9C>G, c.788A>C, and c.9938G>T polymorphisms were investigated and circulating levels of TRAIL and OPG were measured. Results The TRAIL c.49G>A, c.615A>G, and c.662T>C; the DR4 c.626G>C; the DR5 c.72T>G; the OPG c.788A>C and c.9938G>T polymorphisms were not observed. The genotype distributions and allele frequencies of single or combined polymorphisms of TRAIL, DR4, DR5, and OPG measured in women with endometriosis were not diVerent from those in women without endometriosis, regardless of endometriosis stage. Serum TRAIL and OPG levels were signiWcantly lower in women with endometriosis than in women without endometriosis, but these levels did not show diVerences between early and advanced endometri-osis. Conclusions Endometriosis is associated with circulating TRAIL and OPG levels in Korean women but not with the TRAIL, DR, and OPG polymorphisms.
KW - DR
KW - Endometriosis
KW - OPG
KW - Polymorphism
KW - TRAIL
UR - http://www.scopus.com/inward/record.url?scp=84864421337&partnerID=8YFLogxK
U2 - 10.1007/s00404-012-2263-0
DO - 10.1007/s00404-012-2263-0
M3 - Article
C2 - 22392486
AN - SCOPUS:84864421337
SN - 0932-0067
VL - 286
SP - 147
EP - 153
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 1
ER -