Association between diabetes mellitus and oncological outcomes in bladder cancer patients undergoing radical cystectomy

Jong Jin Oh, Min Yong Kang, Jung Ki Jo, Hak Min Lee, Seok-Soo Byun, Sang Eun Lee, Sang Chul Lee, Sung Kyu Hong

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective: To determine the association between diabetes mellitus and oncological outcomes in urothelial bladder cancer patients undergoing radical cystectomy. Methods: From January 2004 to December 2014, 200 non-metastatic urothelial bladder cancer patients who underwent radical cystectomy were divided into two groups according to diabetes mellitus status at the time of surgery. Kaplan-Meier and Cox regression analysis were used to assess the association between diabetes mellitus and urothelial bladder cancer recurrence-free, cancer-specific and overall mortality. Results: Of the 200 patients, 28 (14%) had diabetes mellitus and presented similar preoperative factors and pathological findings after radical cystectomy, including pathological stage, grade, lymph node invasion and positive surgical margin compared with non-diabetes mellitus patients (n=172). The 5-year cancer-specific survivals were 92.3% and 62.1% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.022). Multivariate Cox regression analysis showed that diabetes mellitus was a significant predictor for cancer-specific mortality (hazard ratio 1.785, P=0.038). The 5-year overall survival rate was 92.1% and 59.4% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.014), and diabetes mellitus was a significant factor for overall mortality by multivariate Cox regression analysis (hazard ratio 1.281, P=0.042). Conclusions: Among bladder cancer patients who underwent radical cystectomy, the diabetes mellitus patients had worse cancer-specific mortality and overall mortality outcomes than the non-diabetes mellitus patients. The mechanism of association between diabetes mellitus and urothelial bladder cancer should be investigated to validate the present results in a future prospective study.

Original languageEnglish
Pages (from-to)1112-1117
Number of pages6
JournalInternational Journal of Urology
Volume22
Issue number12
DOIs
StatePublished - 1 Dec 2015

Fingerprint

Cystectomy
Urinary Bladder Neoplasms
Diabetes Mellitus
Mortality
Regression Analysis
Neoplasms
Survival Rate
Lymph Nodes
Prospective Studies
Recurrence
Survival

Keywords

  • Bladder
  • Bladder cancer
  • Diabetes mellitus
  • Radical cystectomy
  • Survival

Cite this

@article{7545c3ffb4644a76b07f50ca7e02dd66,
title = "Association between diabetes mellitus and oncological outcomes in bladder cancer patients undergoing radical cystectomy",
abstract = "Objective: To determine the association between diabetes mellitus and oncological outcomes in urothelial bladder cancer patients undergoing radical cystectomy. Methods: From January 2004 to December 2014, 200 non-metastatic urothelial bladder cancer patients who underwent radical cystectomy were divided into two groups according to diabetes mellitus status at the time of surgery. Kaplan-Meier and Cox regression analysis were used to assess the association between diabetes mellitus and urothelial bladder cancer recurrence-free, cancer-specific and overall mortality. Results: Of the 200 patients, 28 (14{\%}) had diabetes mellitus and presented similar preoperative factors and pathological findings after radical cystectomy, including pathological stage, grade, lymph node invasion and positive surgical margin compared with non-diabetes mellitus patients (n=172). The 5-year cancer-specific survivals were 92.3{\%} and 62.1{\%} in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.022). Multivariate Cox regression analysis showed that diabetes mellitus was a significant predictor for cancer-specific mortality (hazard ratio 1.785, P=0.038). The 5-year overall survival rate was 92.1{\%} and 59.4{\%} in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.014), and diabetes mellitus was a significant factor for overall mortality by multivariate Cox regression analysis (hazard ratio 1.281, P=0.042). Conclusions: Among bladder cancer patients who underwent radical cystectomy, the diabetes mellitus patients had worse cancer-specific mortality and overall mortality outcomes than the non-diabetes mellitus patients. The mechanism of association between diabetes mellitus and urothelial bladder cancer should be investigated to validate the present results in a future prospective study.",
keywords = "Bladder, Bladder cancer, Diabetes mellitus, Radical cystectomy, Survival",
author = "Oh, {Jong Jin} and Kang, {Min Yong} and Jo, {Jung Ki} and Lee, {Hak Min} and Seok-Soo Byun and Lee, {Sang Eun} and Lee, {Sang Chul} and Hong, {Sung Kyu}",
year = "2015",
month = "12",
day = "1",
doi = "10.1111/iju.12901",
language = "English",
volume = "22",
pages = "1112--1117",
journal = "International Journal of Urology",
issn = "0919-8172",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "12",

}

TY - JOUR

T1 - Association between diabetes mellitus and oncological outcomes in bladder cancer patients undergoing radical cystectomy

AU - Oh, Jong Jin

AU - Kang, Min Yong

AU - Jo, Jung Ki

AU - Lee, Hak Min

AU - Byun, Seok-Soo

AU - Lee, Sang Eun

AU - Lee, Sang Chul

AU - Hong, Sung Kyu

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Objective: To determine the association between diabetes mellitus and oncological outcomes in urothelial bladder cancer patients undergoing radical cystectomy. Methods: From January 2004 to December 2014, 200 non-metastatic urothelial bladder cancer patients who underwent radical cystectomy were divided into two groups according to diabetes mellitus status at the time of surgery. Kaplan-Meier and Cox regression analysis were used to assess the association between diabetes mellitus and urothelial bladder cancer recurrence-free, cancer-specific and overall mortality. Results: Of the 200 patients, 28 (14%) had diabetes mellitus and presented similar preoperative factors and pathological findings after radical cystectomy, including pathological stage, grade, lymph node invasion and positive surgical margin compared with non-diabetes mellitus patients (n=172). The 5-year cancer-specific survivals were 92.3% and 62.1% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.022). Multivariate Cox regression analysis showed that diabetes mellitus was a significant predictor for cancer-specific mortality (hazard ratio 1.785, P=0.038). The 5-year overall survival rate was 92.1% and 59.4% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.014), and diabetes mellitus was a significant factor for overall mortality by multivariate Cox regression analysis (hazard ratio 1.281, P=0.042). Conclusions: Among bladder cancer patients who underwent radical cystectomy, the diabetes mellitus patients had worse cancer-specific mortality and overall mortality outcomes than the non-diabetes mellitus patients. The mechanism of association between diabetes mellitus and urothelial bladder cancer should be investigated to validate the present results in a future prospective study.

AB - Objective: To determine the association between diabetes mellitus and oncological outcomes in urothelial bladder cancer patients undergoing radical cystectomy. Methods: From January 2004 to December 2014, 200 non-metastatic urothelial bladder cancer patients who underwent radical cystectomy were divided into two groups according to diabetes mellitus status at the time of surgery. Kaplan-Meier and Cox regression analysis were used to assess the association between diabetes mellitus and urothelial bladder cancer recurrence-free, cancer-specific and overall mortality. Results: Of the 200 patients, 28 (14%) had diabetes mellitus and presented similar preoperative factors and pathological findings after radical cystectomy, including pathological stage, grade, lymph node invasion and positive surgical margin compared with non-diabetes mellitus patients (n=172). The 5-year cancer-specific survivals were 92.3% and 62.1% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.022). Multivariate Cox regression analysis showed that diabetes mellitus was a significant predictor for cancer-specific mortality (hazard ratio 1.785, P=0.038). The 5-year overall survival rate was 92.1% and 59.4% in the non-diabetes mellitus and diabetes mellitus groups, respectively (P=0.014), and diabetes mellitus was a significant factor for overall mortality by multivariate Cox regression analysis (hazard ratio 1.281, P=0.042). Conclusions: Among bladder cancer patients who underwent radical cystectomy, the diabetes mellitus patients had worse cancer-specific mortality and overall mortality outcomes than the non-diabetes mellitus patients. The mechanism of association between diabetes mellitus and urothelial bladder cancer should be investigated to validate the present results in a future prospective study.

KW - Bladder

KW - Bladder cancer

KW - Diabetes mellitus

KW - Radical cystectomy

KW - Survival

UR - http://www.scopus.com/inward/record.url?scp=84958771918&partnerID=8YFLogxK

U2 - 10.1111/iju.12901

DO - 10.1111/iju.12901

M3 - Article

C2 - 26290403

AN - SCOPUS:84958771918

VL - 22

SP - 1112

EP - 1117

JO - International Journal of Urology

JF - International Journal of Urology

SN - 0919-8172

IS - 12

ER -