Association between deterioration in muscle strength and peripheral neuropathy in people with diabetes

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aims: Diabetic peripheral neuropathy (DPN) is a major risk factor for sarcopenia or frailty in older patients with diabetes. In this study, we investigated the association between DPN and muscle strength in type 2 diabetes. Methods: DPN was assessed using the Michigan Neuropathy Screening Instrument Questionnaire (MNSI-Q) and Physical Examination (MNSI-PE) in 230 subjects with type 2 diabetes. Handgrip strength (HGS) was measured using an electronic grip strength dynamometer. Results: The prevalence of DPN was 26.4% in men and 34.7% in women. HGS was significantly lower in men with DPN compared with men without DPN (27.0 ± 9.4 vs. 29.7 ± 8.4 kg, p = 0.036). This effect was not seen in women. In men, multivariate regression analysis showed that HGS was negatively associated with the MNSI-Q (β = −1.200, p = 0.003) and MNSI-PE scores (β = −0.937, p = 0.046) and resulted in an abnormal 10-gram monofilament test score (β = −10.895, p < 0.001). However, HGS was not significantly associated with neuropathy in women. Conclusions: Muscle strength was lower in men with DPN than in those without DPN. Assessment of muscle function may have clinical implications in the prevention of sarcopenia and frailty in men with DPN.

Original languageEnglish
Pages (from-to)598-601
Number of pages4
JournalJournal of Diabetes and its Complications
Volume33
Issue number8
DOIs
StatePublished - 1 Aug 2019

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Diabetic Neuropathies
Muscle Strength
Peripheral Nervous System Diseases
Sarcopenia
Type 2 Diabetes Mellitus
Physical Examination
Hand Strength
Multivariate Analysis
Regression Analysis
Muscles

Keywords

  • Handgrip strength
  • Muscle function
  • Neuropathy
  • Sarcopenia
  • Type 2 diabetes

Cite this

@article{92193ae4ada249778aa8ae6f9c36acf7,
title = "Association between deterioration in muscle strength and peripheral neuropathy in people with diabetes",
abstract = "Aims: Diabetic peripheral neuropathy (DPN) is a major risk factor for sarcopenia or frailty in older patients with diabetes. In this study, we investigated the association between DPN and muscle strength in type 2 diabetes. Methods: DPN was assessed using the Michigan Neuropathy Screening Instrument Questionnaire (MNSI-Q) and Physical Examination (MNSI-PE) in 230 subjects with type 2 diabetes. Handgrip strength (HGS) was measured using an electronic grip strength dynamometer. Results: The prevalence of DPN was 26.4{\%} in men and 34.7{\%} in women. HGS was significantly lower in men with DPN compared with men without DPN (27.0 ± 9.4 vs. 29.7 ± 8.4 kg, p = 0.036). This effect was not seen in women. In men, multivariate regression analysis showed that HGS was negatively associated with the MNSI-Q (β = −1.200, p = 0.003) and MNSI-PE scores (β = −0.937, p = 0.046) and resulted in an abnormal 10-gram monofilament test score (β = −10.895, p < 0.001). However, HGS was not significantly associated with neuropathy in women. Conclusions: Muscle strength was lower in men with DPN than in those without DPN. Assessment of muscle function may have clinical implications in the prevention of sarcopenia and frailty in men with DPN.",
keywords = "Handgrip strength, Muscle function, Neuropathy, Sarcopenia, Type 2 diabetes",
author = "Oh, {Tae Jung} and Sunyoung Kang and Lee, {Jie Eun} and Moon, {Jae Hoon} and Choi, {Sung Hee} and Soo Lim and Jang, {Hak Chul}",
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language = "English",
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Association between deterioration in muscle strength and peripheral neuropathy in people with diabetes. / Oh, Tae Jung; Kang, Sunyoung; Lee, Jie Eun; Moon, Jae Hoon; Choi, Sung Hee; Lim, Soo; Jang, Hak Chul.

In: Journal of Diabetes and its Complications, Vol. 33, No. 8, 01.08.2019, p. 598-601.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Association between deterioration in muscle strength and peripheral neuropathy in people with diabetes

AU - Oh, Tae Jung

AU - Kang, Sunyoung

AU - Lee, Jie Eun

AU - Moon, Jae Hoon

AU - Choi, Sung Hee

AU - Lim, Soo

AU - Jang, Hak Chul

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Aims: Diabetic peripheral neuropathy (DPN) is a major risk factor for sarcopenia or frailty in older patients with diabetes. In this study, we investigated the association between DPN and muscle strength in type 2 diabetes. Methods: DPN was assessed using the Michigan Neuropathy Screening Instrument Questionnaire (MNSI-Q) and Physical Examination (MNSI-PE) in 230 subjects with type 2 diabetes. Handgrip strength (HGS) was measured using an electronic grip strength dynamometer. Results: The prevalence of DPN was 26.4% in men and 34.7% in women. HGS was significantly lower in men with DPN compared with men without DPN (27.0 ± 9.4 vs. 29.7 ± 8.4 kg, p = 0.036). This effect was not seen in women. In men, multivariate regression analysis showed that HGS was negatively associated with the MNSI-Q (β = −1.200, p = 0.003) and MNSI-PE scores (β = −0.937, p = 0.046) and resulted in an abnormal 10-gram monofilament test score (β = −10.895, p < 0.001). However, HGS was not significantly associated with neuropathy in women. Conclusions: Muscle strength was lower in men with DPN than in those without DPN. Assessment of muscle function may have clinical implications in the prevention of sarcopenia and frailty in men with DPN.

AB - Aims: Diabetic peripheral neuropathy (DPN) is a major risk factor for sarcopenia or frailty in older patients with diabetes. In this study, we investigated the association between DPN and muscle strength in type 2 diabetes. Methods: DPN was assessed using the Michigan Neuropathy Screening Instrument Questionnaire (MNSI-Q) and Physical Examination (MNSI-PE) in 230 subjects with type 2 diabetes. Handgrip strength (HGS) was measured using an electronic grip strength dynamometer. Results: The prevalence of DPN was 26.4% in men and 34.7% in women. HGS was significantly lower in men with DPN compared with men without DPN (27.0 ± 9.4 vs. 29.7 ± 8.4 kg, p = 0.036). This effect was not seen in women. In men, multivariate regression analysis showed that HGS was negatively associated with the MNSI-Q (β = −1.200, p = 0.003) and MNSI-PE scores (β = −0.937, p = 0.046) and resulted in an abnormal 10-gram monofilament test score (β = −10.895, p < 0.001). However, HGS was not significantly associated with neuropathy in women. Conclusions: Muscle strength was lower in men with DPN than in those without DPN. Assessment of muscle function may have clinical implications in the prevention of sarcopenia and frailty in men with DPN.

KW - Handgrip strength

KW - Muscle function

KW - Neuropathy

KW - Sarcopenia

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DO - 10.1016/j.jdiacomp.2019.04.007

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EP - 601

JO - Journal of Diabetes and its Complications

JF - Journal of Diabetes and its Complications

SN - 1056-8727

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