Association between body mass index and gastric cancer risk according to effect modification by helicobacter pylori infection

Jieun Jang, Eun Jung Cho, Yunji Hwang, Elisabete Weiderpass, Choonghyun Ahn, Jeoungbin Choi, Soung Hoon Chang, Hai Rim Shin, Min Kyung Lim, Keun Young Yoo, Sue K. Park

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Purpose Few studies investigated roles of body mass index (BMI) on gastric cancer (GC) risk according to Helicobacter pylori infection status. This study was conducted to evaluate associations between BMI and GC risk with consideration of H. pylori infection information. Materials and Methods We performed a case-cohort study (n=2,458) that consists of a subcohort (n=2,193 including 67 GC incident cases) randomly selected from the Korean Multicenter Cancer Cohort (KMCC) and 265 incident GC cases outside of the subcohort. H. pylori infection was assessed using an immunoblot assay. GC risk according to BMI was evaluated by calculating hazard ratios (HRs) and their 95% confidence intervals (95% CIs) using weighted Cox hazard regression model. Results Increased GC risk in lower BMI group (< 23 kg/m2) with marginal significance (HR, 1.32; 95% CI, 0.98 to 1.77) compared to the reference group (BMI of 23-24.9 kg/m2) was observed. In the H. pylori non-infection, both lower (< 23 kg/m2) and higher BMI (! 25 kg/m2) showed non-significantly increased GC risk (HR, 10.82; 95% CI, 1.25 to 93.60 and HR, 11.33; 95% CI, 1.13 to 113.66, respectively). However, these U-shaped associations between BMI and GC risk were not observed in the group who had ever been infected by H. pylori. Conclusion This study suggests the U-shaped associations between BMI and GC risk, especially in subjects who had never been infected by H. pylori.

Original languageEnglish
Pages (from-to)1107-1116
Number of pages10
JournalCancer Research and Treatment
Volume51
Issue number3
DOIs
StatePublished - 1 Jul 2019

Keywords

  • Body mass index
  • Case-cohort
  • Cohort studies
  • Effect modification
  • Helicobacter pylori
  • Stomach neoplasms

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