Assessment of hepatic sinusoidal obstruction syndrome with intravoxel incoherent motion diffusion-weighted imaging: An experimental study in a rat model

Eun Kyoung Hong, Ijin Joo, Juil Park, Kyoungbun Lee

Research output: Contribution to journalArticle

Abstract

Background: Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters may reflect perfusion and diffusion changes in hepatic sinusoidal obstruction syndrome (SOS). Purpose: To investigate the feasibility of IVIM-DWI in the noninvasive assessment of hepatic SOS in an experimental rat model. Study Type: Animal study. Population/Subjects: Forty-four rats were administered different doses (90 or 160 mg/kg) of monocrotaline by gavage either 48 or 72 hours before MRI to induce different degrees of hepatic SOS, and another 10 rats served as controls. Field Strength/Sequence: 3T scanner, IVIM-DWI using nine b values (0–800 sec/mm2). Assessment: Histologically, rats were classified as having none (n = 10), mild (n = 8), moderate (n = 19), or severe SOS (n = 17). The apparent diffusion coefficient (ADC) and IVIM-derived parameters (D: true diffusion coefficient, D*: pseudo-diffusion coefficient, and f: perfusion fraction) of the liver parenchyma were measured. Statistical Tests: IVIM-DWI parameters were compared according to histologic grades of SOS (none, mild, moderate, and severe), and receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic accuracy. Results: ADC, D, and f of the liver parenchyma were significantly different according to SOS severity groups (Ps < 0.01) and significantly decreased as SOS severity increased (rho = –0.323, –0.313, and –0.700; P = 0.017, 0.021, and <0.001, respectively). Means of f in none, mild, moderate, and severe SOS were 17.2%, 13.3%, 12.3%, and 11.1%, respectively. Among ADC and IVIM-derived parameters, f provided the highest area under the ROC curves for detecting ≥mild, ≥moderate, and severe SOS (0.991, 0.890, and 0.803, respectively). Data Conclusion: IVIM-DWI may be useful in the diagnosis and severity assessment of hepatic SOS. Level of Evidence: 2. Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:81–89.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalJournal of Magnetic Resonance Imaging
Volume51
Issue number1
DOIs
StatePublished - 1 Jan 2020

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Hepatic Veno-Occlusive Disease
Liver
ROC Curve
Perfusion
Monocrotaline

Keywords

  • diffusion-weighted imaging (DWI)
  • intravoxel incoherent motion (IVIM)
  • liver
  • sinusoidal obstruction syndrome

Cite this

@article{e0cfbb7150af4195ac07145543c600a7,
title = "Assessment of hepatic sinusoidal obstruction syndrome with intravoxel incoherent motion diffusion-weighted imaging: An experimental study in a rat model",
abstract = "Background: Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters may reflect perfusion and diffusion changes in hepatic sinusoidal obstruction syndrome (SOS). Purpose: To investigate the feasibility of IVIM-DWI in the noninvasive assessment of hepatic SOS in an experimental rat model. Study Type: Animal study. Population/Subjects: Forty-four rats were administered different doses (90 or 160 mg/kg) of monocrotaline by gavage either 48 or 72 hours before MRI to induce different degrees of hepatic SOS, and another 10 rats served as controls. Field Strength/Sequence: 3T scanner, IVIM-DWI using nine b values (0–800 sec/mm2). Assessment: Histologically, rats were classified as having none (n = 10), mild (n = 8), moderate (n = 19), or severe SOS (n = 17). The apparent diffusion coefficient (ADC) and IVIM-derived parameters (D: true diffusion coefficient, D*: pseudo-diffusion coefficient, and f: perfusion fraction) of the liver parenchyma were measured. Statistical Tests: IVIM-DWI parameters were compared according to histologic grades of SOS (none, mild, moderate, and severe), and receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic accuracy. Results: ADC, D, and f of the liver parenchyma were significantly different according to SOS severity groups (Ps < 0.01) and significantly decreased as SOS severity increased (rho = –0.323, –0.313, and –0.700; P = 0.017, 0.021, and <0.001, respectively). Means of f in none, mild, moderate, and severe SOS were 17.2{\%}, 13.3{\%}, 12.3{\%}, and 11.1{\%}, respectively. Among ADC and IVIM-derived parameters, f provided the highest area under the ROC curves for detecting ≥mild, ≥moderate, and severe SOS (0.991, 0.890, and 0.803, respectively). Data Conclusion: IVIM-DWI may be useful in the diagnosis and severity assessment of hepatic SOS. Level of Evidence: 2. Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:81–89.",
keywords = "diffusion-weighted imaging (DWI), intravoxel incoherent motion (IVIM), liver, sinusoidal obstruction syndrome",
author = "Hong, {Eun Kyoung} and Ijin Joo and Juil Park and Kyoungbun Lee",
year = "2020",
month = "1",
day = "1",
doi = "10.1002/jmri.26790",
language = "English",
volume = "51",
pages = "81--89",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
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TY - JOUR

T1 - Assessment of hepatic sinusoidal obstruction syndrome with intravoxel incoherent motion diffusion-weighted imaging

T2 - An experimental study in a rat model

AU - Hong, Eun Kyoung

AU - Joo, Ijin

AU - Park, Juil

AU - Lee, Kyoungbun

PY - 2020/1/1

Y1 - 2020/1/1

N2 - Background: Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters may reflect perfusion and diffusion changes in hepatic sinusoidal obstruction syndrome (SOS). Purpose: To investigate the feasibility of IVIM-DWI in the noninvasive assessment of hepatic SOS in an experimental rat model. Study Type: Animal study. Population/Subjects: Forty-four rats were administered different doses (90 or 160 mg/kg) of monocrotaline by gavage either 48 or 72 hours before MRI to induce different degrees of hepatic SOS, and another 10 rats served as controls. Field Strength/Sequence: 3T scanner, IVIM-DWI using nine b values (0–800 sec/mm2). Assessment: Histologically, rats were classified as having none (n = 10), mild (n = 8), moderate (n = 19), or severe SOS (n = 17). The apparent diffusion coefficient (ADC) and IVIM-derived parameters (D: true diffusion coefficient, D*: pseudo-diffusion coefficient, and f: perfusion fraction) of the liver parenchyma were measured. Statistical Tests: IVIM-DWI parameters were compared according to histologic grades of SOS (none, mild, moderate, and severe), and receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic accuracy. Results: ADC, D, and f of the liver parenchyma were significantly different according to SOS severity groups (Ps < 0.01) and significantly decreased as SOS severity increased (rho = –0.323, –0.313, and –0.700; P = 0.017, 0.021, and <0.001, respectively). Means of f in none, mild, moderate, and severe SOS were 17.2%, 13.3%, 12.3%, and 11.1%, respectively. Among ADC and IVIM-derived parameters, f provided the highest area under the ROC curves for detecting ≥mild, ≥moderate, and severe SOS (0.991, 0.890, and 0.803, respectively). Data Conclusion: IVIM-DWI may be useful in the diagnosis and severity assessment of hepatic SOS. Level of Evidence: 2. Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:81–89.

AB - Background: Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters may reflect perfusion and diffusion changes in hepatic sinusoidal obstruction syndrome (SOS). Purpose: To investigate the feasibility of IVIM-DWI in the noninvasive assessment of hepatic SOS in an experimental rat model. Study Type: Animal study. Population/Subjects: Forty-four rats were administered different doses (90 or 160 mg/kg) of monocrotaline by gavage either 48 or 72 hours before MRI to induce different degrees of hepatic SOS, and another 10 rats served as controls. Field Strength/Sequence: 3T scanner, IVIM-DWI using nine b values (0–800 sec/mm2). Assessment: Histologically, rats were classified as having none (n = 10), mild (n = 8), moderate (n = 19), or severe SOS (n = 17). The apparent diffusion coefficient (ADC) and IVIM-derived parameters (D: true diffusion coefficient, D*: pseudo-diffusion coefficient, and f: perfusion fraction) of the liver parenchyma were measured. Statistical Tests: IVIM-DWI parameters were compared according to histologic grades of SOS (none, mild, moderate, and severe), and receiver operating characteristic (ROC) curve analysis was performed to determine the diagnostic accuracy. Results: ADC, D, and f of the liver parenchyma were significantly different according to SOS severity groups (Ps < 0.01) and significantly decreased as SOS severity increased (rho = –0.323, –0.313, and –0.700; P = 0.017, 0.021, and <0.001, respectively). Means of f in none, mild, moderate, and severe SOS were 17.2%, 13.3%, 12.3%, and 11.1%, respectively. Among ADC and IVIM-derived parameters, f provided the highest area under the ROC curves for detecting ≥mild, ≥moderate, and severe SOS (0.991, 0.890, and 0.803, respectively). Data Conclusion: IVIM-DWI may be useful in the diagnosis and severity assessment of hepatic SOS. Level of Evidence: 2. Technical Efficacy Stage: 2 J. Magn. Reson. Imaging 2020;51:81–89.

KW - diffusion-weighted imaging (DWI)

KW - intravoxel incoherent motion (IVIM)

KW - liver

KW - sinusoidal obstruction syndrome

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