Application of the Epstein criteria for prediction of clinically insignificant prostate cancer in Korean men

S. E. Lee, D. S. Kim, W. K. Lee, H. Z. Park, C. J. Lee, S. H. Doo, Seong Jin Jeong, C. Y. Yoon, Seok-Soo Byun, Gheeyoung Choe, Sung Il Hwang, H. J. Lee, Sung Kyu Hong

Research output: Contribution to journalComment/debate

Abstract

Objective: To investigate the rate of pathologically confirmed unfavourable prostate cancers among Korean men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer. Patients and Methods: This was a retrospective study of 131 Korean men who underwent radical prostatectomy (RP) for clinically insignificant prostate cancer as defined by contemporary Epstein criteria. We assessed the percentage of unfavourable prostate cancer (pathological Gleason sum > or = 7 and/or extraprostatic extension [EPE]) among these men and tried to identify useful predictors for such unfavourable tumour profiles using uni- and multivariate analyses.Results: Among 131 men with clinically insignificant prostate cancer, 40 (30.5%) had pathological Gleason > or = 7 tumours after RP. Of these 40 men, four (3.1%) also had EPE on examination of RP specimen. All those who did not have Gleason score upgrading after RP had organ-confined disease from examination of RP specimen. Overall, 40 (30.5%) of the 131 men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer before RP had pathologically unfavourable disease. Among our patients, no significant preoperativepredictor of pathologically unfavourable disease was identified using uni- and multivariate analyses.Conclusion: Our results showed that a significant proportion of contemporary Korean patients who meet all the conditions of the contemporary Epstein criteria for prediction of clinically insignificant prostate cancer might actually harbour prostate cancer with unfavourable pathological features. Such findings should be considered when treatment options are contemplated based upon the Epstein criteria among Asian patients.

Original languageEnglish
Pages (from-to)122
Number of pages1
JournalInternational Braz J Urol
Volume37
Issue number1
DOIs
StatePublished - 1 Jan 2011

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Prostatic Neoplasms
Prostatectomy
Multivariate Analysis
Neoplasm Grading
Neoplasms
Retrospective Studies

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title = "Application of the Epstein criteria for prediction of clinically insignificant prostate cancer in Korean men",
abstract = "Objective: To investigate the rate of pathologically confirmed unfavourable prostate cancers among Korean men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer. Patients and Methods: This was a retrospective study of 131 Korean men who underwent radical prostatectomy (RP) for clinically insignificant prostate cancer as defined by contemporary Epstein criteria. We assessed the percentage of unfavourable prostate cancer (pathological Gleason sum > or = 7 and/or extraprostatic extension [EPE]) among these men and tried to identify useful predictors for such unfavourable tumour profiles using uni- and multivariate analyses.Results: Among 131 men with clinically insignificant prostate cancer, 40 (30.5{\%}) had pathological Gleason > or = 7 tumours after RP. Of these 40 men, four (3.1{\%}) also had EPE on examination of RP specimen. All those who did not have Gleason score upgrading after RP had organ-confined disease from examination of RP specimen. Overall, 40 (30.5{\%}) of the 131 men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer before RP had pathologically unfavourable disease. Among our patients, no significant preoperativepredictor of pathologically unfavourable disease was identified using uni- and multivariate analyses.Conclusion: Our results showed that a significant proportion of contemporary Korean patients who meet all the conditions of the contemporary Epstein criteria for prediction of clinically insignificant prostate cancer might actually harbour prostate cancer with unfavourable pathological features. Such findings should be considered when treatment options are contemplated based upon the Epstein criteria among Asian patients.",
author = "Lee, {S. E.} and Kim, {D. S.} and Lee, {W. K.} and Park, {H. Z.} and Lee, {C. J.} and Doo, {S. H.} and Jeong, {Seong Jin} and Yoon, {C. Y.} and Seok-Soo Byun and Gheeyoung Choe and Hwang, {Sung Il} and Lee, {H. J.} and Hong, {Sung Kyu}",
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Application of the Epstein criteria for prediction of clinically insignificant prostate cancer in Korean men. / Lee, S. E.; Kim, D. S.; Lee, W. K.; Park, H. Z.; Lee, C. J.; Doo, S. H.; Jeong, Seong Jin; Yoon, C. Y.; Byun, Seok-Soo; Choe, Gheeyoung; Hwang, Sung Il; Lee, H. J.; Hong, Sung Kyu.

In: International Braz J Urol, Vol. 37, No. 1, 01.01.2011, p. 122.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Application of the Epstein criteria for prediction of clinically insignificant prostate cancer in Korean men

AU - Lee, S. E.

AU - Kim, D. S.

AU - Lee, W. K.

AU - Park, H. Z.

AU - Lee, C. J.

AU - Doo, S. H.

AU - Jeong, Seong Jin

AU - Yoon, C. Y.

AU - Byun, Seok-Soo

AU - Choe, Gheeyoung

AU - Hwang, Sung Il

AU - Lee, H. J.

AU - Hong, Sung Kyu

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Objective: To investigate the rate of pathologically confirmed unfavourable prostate cancers among Korean men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer. Patients and Methods: This was a retrospective study of 131 Korean men who underwent radical prostatectomy (RP) for clinically insignificant prostate cancer as defined by contemporary Epstein criteria. We assessed the percentage of unfavourable prostate cancer (pathological Gleason sum > or = 7 and/or extraprostatic extension [EPE]) among these men and tried to identify useful predictors for such unfavourable tumour profiles using uni- and multivariate analyses.Results: Among 131 men with clinically insignificant prostate cancer, 40 (30.5%) had pathological Gleason > or = 7 tumours after RP. Of these 40 men, four (3.1%) also had EPE on examination of RP specimen. All those who did not have Gleason score upgrading after RP had organ-confined disease from examination of RP specimen. Overall, 40 (30.5%) of the 131 men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer before RP had pathologically unfavourable disease. Among our patients, no significant preoperativepredictor of pathologically unfavourable disease was identified using uni- and multivariate analyses.Conclusion: Our results showed that a significant proportion of contemporary Korean patients who meet all the conditions of the contemporary Epstein criteria for prediction of clinically insignificant prostate cancer might actually harbour prostate cancer with unfavourable pathological features. Such findings should be considered when treatment options are contemplated based upon the Epstein criteria among Asian patients.

AB - Objective: To investigate the rate of pathologically confirmed unfavourable prostate cancers among Korean men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer. Patients and Methods: This was a retrospective study of 131 Korean men who underwent radical prostatectomy (RP) for clinically insignificant prostate cancer as defined by contemporary Epstein criteria. We assessed the percentage of unfavourable prostate cancer (pathological Gleason sum > or = 7 and/or extraprostatic extension [EPE]) among these men and tried to identify useful predictors for such unfavourable tumour profiles using uni- and multivariate analyses.Results: Among 131 men with clinically insignificant prostate cancer, 40 (30.5%) had pathological Gleason > or = 7 tumours after RP. Of these 40 men, four (3.1%) also had EPE on examination of RP specimen. All those who did not have Gleason score upgrading after RP had organ-confined disease from examination of RP specimen. Overall, 40 (30.5%) of the 131 men who fulfilled the contemporary Epstein criteria for clinically insignificant prostate cancer before RP had pathologically unfavourable disease. Among our patients, no significant preoperativepredictor of pathologically unfavourable disease was identified using uni- and multivariate analyses.Conclusion: Our results showed that a significant proportion of contemporary Korean patients who meet all the conditions of the contemporary Epstein criteria for prediction of clinically insignificant prostate cancer might actually harbour prostate cancer with unfavourable pathological features. Such findings should be considered when treatment options are contemplated based upon the Epstein criteria among Asian patients.

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U2 - 10.1590/S1677-55382011000100021

DO - 10.1590/S1677-55382011000100021

M3 - Comment/debate

AN - SCOPUS:79955883756

VL - 37

SP - 122

JO - International Braz J Urol

JF - International Braz J Urol

SN - 1677-5538

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