Abstract
Recently, large molecules or nanoparticles are actively studied as radiopharmaceuticals. However, their kinetics is problematic because of a slow penetration through the capillaries and slow distribution to the target. To improve the kinetics, a two-step targeting method can be applied by using small molecules and very rapid copper-free click reaction. Although this method might have limitations such as internalization of the first targeted conjugate, it will provide high target-to-non-target ratio imaging of radiopharmaceuticals.
Original language | English |
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Pages (from-to) | 99-101 |
Number of pages | 3 |
Journal | Nuclear Medicine and Molecular Imaging |
Volume | 50 |
Issue number | 2 |
DOIs | |
State | Published - 1 Jun 2016 |
Bibliographical note
Publisher Copyright:© 2015, Korean Society of Nuclear Medicine.