Antibody Responses One Year after Mild SARS-CoV-2 Infection

Pyoeng Gyun Choe; Kye Hyung Kim; Chang Kyung Kang; Hyeon Jeong Suh; Eun Kyo Kang; Sun Young Lee; Nam Joong Kim; Jongyoun Yi; Wan Beom Park; Myoung Don Oh

doi:10.3346/jkms.2021.36.e157

Antibody Responses One Year after Mild SARS-CoV-2 Infection

Pyoeng Gyun Choe, Kye Hyung Kim, Chang Kyung Kang, Hyeon Jeong Suh, Eun Kyo Kang, Sun Young Lee, Nam Joong Kim, Jongyoun Yi, Wan Beom Park, Myoung Don Oh

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.

Original language	English
Pages (from-to)	1-4
Number of pages	4
Journal	Journal of Korean Medical Science
Volume	36
Issue number	21
DOIs	https://doi.org/10.3346/jkms.2021.36.e157
State	Published - 2021

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Publisher Copyright:
© 2021 The Korean Academy of Medical Sciences. All Rights Reserved.

Keywords

Antibody
COVID-19
ECLIA
ELISA
SARS-CoV-2

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abstract = "Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.",

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AU - Kang, Chang Kyung

AU - Suh, Hyeon Jeong

AU - Kang, Eun Kyo

AU - Lee, Sun Young

AU - Kim, Nam Joong

AU - Yi, Jongyoun

AU - Park, Wan Beom

AU - Oh, Myoung Don

PY - 2021

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AB - Understanding the long-term kinetics of antibodies in coronavirus disease 2019 (COVID-19) is essential in interpreting serosurvey data. We investigated the antibody response one year after infection in 52 mildly symptomatic patients with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection, using three commercial immunoassays and a surrogate virus neutralization test (sVNT) kit. Anti-N pan-immunoglobulin (Ig), anti-S IgG, and anti-S1 IgG were detected in 43 (82.7%), 44 (84.6%), and 30 (57.7%), respectively. In 49 (94.2%), the antibody could be detected by either anti-N pan-Ig or anti-S IgG assay. In the sVNT, 30 (57.7%) had positive neutralizing activity. Despite waning immunity, SARS-CoV-2 antibodies can be detected up to one year after infection, even in mild COVID-19 patients.

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Antibody Responses One Year after Mild SARS-CoV-2 Infection

Abstract

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Keywords

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