Anatomic Conformation of Renal Sympathetic Nerve Fibers in Living Human Tissues

Won Seok Choe, Won Hoon Song, Chang Wook Jeong, Eue-Keun Choi, Seil Oh

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Renal denervation using radiofrequency catheter ablation is known to eliminate the renal sympathetic nerve and to lower blood pressure in patients with resistant hypertension. We sought to investigate the detailed anatomic conformation of the peri-renal arterial sympathetic nerve fibers with living human specimens. Peri-renal arterial tissue was harvested from patients undergoing elective radical or simple nephrectomy. Digital images of each section from the distal arterial bifurcation to the proximal margin were obtained and analyzed after immunohistochemical staining with anti-tyrosine hydroxylase antibodies. A total of 3,075 nerve fibers were identified from 84 sections of peri-renal arterial tissue from 28 patients (mean age 62.5 ± 10.2 years, male 68%). Overall, 16% of nerve fibers were located at distances greater than 3 mm from the endoluminal surface of the renal artery. The median distance from the arterial lumen to the nerve fibers of the proximal, middle, and distal renal arterial segments was 1.51 mm, 1.48 mm, and 1.52 mm, respectively. The median diameter of the nerve fibers was 65 μm, and there was no significant difference between the segments. A substantial proportion of the sympathetic nerve fibers were located deeper in the peri-arterial soft tissue than in the lesion depth created by the conventional catheter-based renal sympathetic denervation system.

Original languageEnglish
Article number4831
Pages (from-to)4831
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 18 Mar 2019

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Adrenergic Fibers
Nerve Fibers
Kidney
Sympathectomy
Catheter Ablation
Median Nerve
Tyrosine 3-Monooxygenase
Denervation
Renal Artery
Nephrectomy
Catheters
Staining and Labeling
Blood Pressure
Hypertension
Antibodies

Cite this

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title = "Anatomic Conformation of Renal Sympathetic Nerve Fibers in Living Human Tissues",
abstract = "Renal denervation using radiofrequency catheter ablation is known to eliminate the renal sympathetic nerve and to lower blood pressure in patients with resistant hypertension. We sought to investigate the detailed anatomic conformation of the peri-renal arterial sympathetic nerve fibers with living human specimens. Peri-renal arterial tissue was harvested from patients undergoing elective radical or simple nephrectomy. Digital images of each section from the distal arterial bifurcation to the proximal margin were obtained and analyzed after immunohistochemical staining with anti-tyrosine hydroxylase antibodies. A total of 3,075 nerve fibers were identified from 84 sections of peri-renal arterial tissue from 28 patients (mean age 62.5 ± 10.2 years, male 68{\%}). Overall, 16{\%} of nerve fibers were located at distances greater than 3 mm from the endoluminal surface of the renal artery. The median distance from the arterial lumen to the nerve fibers of the proximal, middle, and distal renal arterial segments was 1.51 mm, 1.48 mm, and 1.52 mm, respectively. The median diameter of the nerve fibers was 65 μm, and there was no significant difference between the segments. A substantial proportion of the sympathetic nerve fibers were located deeper in the peri-arterial soft tissue than in the lesion depth created by the conventional catheter-based renal sympathetic denervation system.",
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Anatomic Conformation of Renal Sympathetic Nerve Fibers in Living Human Tissues. / Choe, Won Seok; Song, Won Hoon; Jeong, Chang Wook; Choi, Eue-Keun; Oh, Seil.

In: Scientific Reports, Vol. 9, No. 1, 4831, 18.03.2019, p. 4831.

Research output: Contribution to journalArticleResearchpeer-review

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